Clinical and Legal Aspects of Nonphysician Prescription of Vitamins, Amino Acids, and Other Nutritional Supplements

Clark, H. Westley; Sees, Karen L.; Nathan, J A

doi:10.1080/02791072.1988.10472505

Cited by 7 publications

(1 citation statement)

References 101 publications

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“…It's when they ask you in your role as educator "what you think" that you need to proceed with caution. In the article, "Clinical and Legal Aspects of Nonphysician Prescription of Vitamins, Amino Acids, and Other Nutritional Supplements, " Clark, Sees, & Nathan (1988) state that:…”

Section: Potential Legal Issuesmentioning

confidence: 99%

Hey Coach, Does This Stuff Work?: What to Know When Discussing Dietary Supplements

Perko

2000

Strategies

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Section: Potential Legal Issuesmentioning

confidence: 99%

Hey Coach, Does This Stuff Work?: What to Know When Discussing Dietary Supplements

Perko

2000

Strategies

View full text Add to dashboard Cite

Survey of Advertising for Nutritional Supplements in Health and Bodybuilding Magazines

Philen

Ortiz²,

Auerbach³

et al. 1992

JAMA

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The use of food supplements by the general public is poorly quantified, and little information on this subject is available in the medical literature. We surveyed 12 recent issues of popular health and bodybuilding magazines (1) to quantify the number of advertisements for food supplements, the number of products advertised, and the number and type of ingredients in these products; (2) to identify the purported health benefits of these products; and (3) as a preliminary effort to identify areas for future research. We counted 89 brands, 311 products, and 235 unique ingredients, the most frequent of which were unspecified amino acids; the most frequently promoted health benefit was muscle growth. We also found many unusual or unidentifiable ingredients, and 22.2% of the products had no ingredients listed in their advertisements. Health professionals may not be aware of how popular food supplements are or of a particular supplement's potential effects or side effects. In addition, patients may be reluctant to discuss their use of these products with traditional medical practitioners. We recommend that routine history taking include specific questions about patients' use of food supplements and that any possible adverse effects or side effects be reported to public health authorities.

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Enhanced Delivery of Retinoic Acid to Breast Cancer Cells by Folate Receptor-Targeted Folic Acid-Conjugated Glutenin Nanoparticles for Promising Treatment of Breast Cancer

Rajeshkumar,

Pavadai,

Panneerselvam

et al. 2023

J Polym Environ

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Targeted delivery via surface receptors can signi cantly improve the therapeutic e cacy and reduce the adverse drug reactions. The protein nanocarrier system offers many advantages, such as encapsulation in various drugs and molecules and prolonged circulation. Here, the folate receptor-targeted folic acidconjugated retinoic acid-loaded glutenin nanoparticles (FA-RA-Glu NPs) were successfully synthesised for enhanced delivery of retinoic acid to breast cancer cells (MCF-7). After a complete physico-chemical characterisation of FA-RA-Glu NPs, stability, drug release, release kinetics, cytotoxicity, apoptosis, cell death, and nucleic acid fragmentation were analysed. The results showed that FA-RA-Glu NPs were 185 nm in size, predominantly spherical in shape, crystalline in nature and had a zeta potential of − 3 mV. The RA encapsulation e ciency and loading capacity of Glu NPs were 83.537% ± 3.32% and 9.917 ± 1.68%, respectively. The effects of FA-RA-Glu NPs against MCF-7 cells signi cantly reduced the number of viable cells and the induction of apoptosis. The cellular uptake study showed that the FA-RA-Glu NPs had facilitated endocytosis and delivered RA into MCF-7 cells. After treatment with FA-RA-Glu NPs, contracted nuclei and deformed membrane bodies were observed as typical apoptotic morphological changes. The released RA also targeted the mitochondria of MCF-7 cells, which signi cantly increased the levels of reactive oxygen species and contributed to the damage of mitochondrial membrane integrity. These results suggest that FA-RA-Glu NPs with facilitated endocytosis and targeted delivery of RA into MCF-7 cells may have signi cant therapeutic potential for the treatment of breast cancer.

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Clinical and Legal Aspects of Nonphysician Prescription of Vitamins, Amino Acids, and Other Nutritional Supplements

Cited by 7 publications

References 101 publications

Hey Coach, Does This Stuff Work?: What to Know When Discussing Dietary Supplements

Hey Coach, Does This Stuff Work?: What to Know When Discussing Dietary Supplements

Survey of Advertising for Nutritional Supplements in Health and Bodybuilding Magazines

Enhanced Delivery of Retinoic Acid to Breast Cancer Cells by Folate Receptor-Targeted Folic Acid-Conjugated Glutenin Nanoparticles for Promising Treatment of Breast Cancer

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