Clinical and meiotic studies in an infertile man with Y; 13 translocation

Mićić, M.; Nikoliš, Jovanka; Mićić, Sava

doi:10.1093/oxfordjournals.humrep.a137804

Cited by 7 publications

(2 citation statements)

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“…This report demonstrate the unique importance of a single growth factor in the regulation of spermatogenesis in mice. Because abnormal spermatogenesis is a feature of many cases of infertility in human males (27,28), the mice generated in this study may be useful models to study infertility in human males.…”

Section: Discussionmentioning

confidence: 99%

A dominant-negative pleiotrophin mutant introduced by homologous recombination leads to germ-cell apoptosis in male mice

Zhang

Yeh²,

Zhong³

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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Pleiotrophin (PTN) is an 18-kDa heparinbinding secretory growth/differentiation factor for different cell types. Its gene is differentially expressed in both mesenchyme and central nervous system during development and highly expressed in a number of different human tumors. Recently, a PTN mutant was found to act as a dominantnegative effector of PTN signaling. We have now used homologous recombination to introduce the dominant-negative PTN mutant into embryonic stem cells to generate chimeric mice. All highly chimeric male mice with germinal epithelium exclusively derived from embryonic stem cells with the heterologous PTN mutation were sterile. Their testes were uniformly atrophic, and the spermatocytes were strikingly apoptotic at all stages of development. The results support a central role of PTN signaling in normal spermatogenesis and suggest that interruption of PTN signaling may lead to sterility in males.

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Section: Discussionmentioning

confidence: 99%

A dominant-negative pleiotrophin mutant introduced by homologous recombination leads to germ-cell apoptosis in male mice

Zhang

Yeh²,

Zhong³

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…For example, previous studies have reported an azoospermic man with a reciprocal translocation t(Yq;13q) and his son with partial trisomy 13q resulting from a paternally inherited translocation (Nikolis et al 1991;Micic et al 1992).…”

Section: Discussionmentioning

confidence: 99%