Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

Tamtaji, Omid Reza; Taghizadeh, Mohsen; Kakhaki, Reza Daneshvar; Kouchaki, Ebrahim; Bahmani, Fereshteh; Borzabadi, Shokoofeh; Oryan, Shahrbanoo; Mafi, Alireza; Asemi, Zatollah

doi:10.1016/j.clnu.2018.05.018

Cited by 293 publications

(210 citation statements)

References 25 publications

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“…These data could enhance the growing amount of basic medical research and clinical application on the efficacy of probiotics in PD treatment. These results are paralleled with PD human studies showing the positive effects in MDS-UPDRS scores of PD patients after a 12-week administration of probiotics [29], encouraging further research into its therapeutic application. Other human studies have also shown several beneficial effects of probiotics in PD, including the alleviation of the symptoms in abdominal pain, bloating, and constipation and the improvements in stool consistency and defecation habits [28,48,49].…”

Section: Discussionsupporting

confidence: 57%

“…It could, therefore, inhibit the harmful gut bacteria and decrease the bacterial translocation, gut leakiness, and the associated neural inflammation in the enteric nervous system (ENS) [24][25][26][27]. Probiotics have been demonstrated as having potential for PD, including the improvement of stool consistency and bowel habits and the reduction of scores from the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) [28,29]. However, there is insufficient preclinical or clinical evidence to show the beneficial effects of probiotics in PD, and detailed underlying effects and mechanisms of probiotics in PD still need further clarification [30].…”

Section: Introductionmentioning

confidence: 99%

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Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

et al. 2020

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Parkinson’s disease (PD) is one of the common long-term degenerative disorders that primarily affect motor systems. Gastrointestinal (GI) symptoms are common in individuals with PD and often present before motor symptoms. It has been found that gut dysbiosis to PD pathology is related to the severity of motor and non-motor symptoms in PD. Probiotics have been reported to have the ability to improve the symptoms related to constipation in PD patients. However, the evidence from preclinical or clinical research to verify the beneficial effects of probiotics for the motor functions in PD is still limited. An experimental PD animal model could be helpful in exploring the potential therapeutic strategy using probiotics. In the current study, we examined whether daily and long-term administration of probiotics has neuroprotective effects on nigrostriatal dopamine neurons and whether it can further alleviate the motor dysfunctions in PD mice. Transgenic MitoPark PD mice were chosen for this study and the effects of daily probiotic treatment on gait, beam balance, motor coordination, and the degeneration levels of dopaminergic neurons were identified. From the results, compared with the sham treatment group, we found that the daily administration of probiotics significantly reduced the motor impairments in gait pattern, balance function, and motor coordination. Immunohistochemically, a tyrosine hydroxylase (TH)-positive cell in the substantia nigra was significantly preserved in the probiotic-treated PD mice. These results showed that long-term administration of probiotics has neuroprotective effects on dopamine neurons and further attenuates the deterioration of motor dysfunctions in MitoPark PD mice. Our data further highlighted the promising possibility of the potential use of probiotics, which could be the relevant approach for further application on human PD subjects.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

et al. 2020

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“…In addition, several preclinical studies involving animals have demonstrated the advantages of probiotics in preventing and treating disorders of the CNS [190]. A study comprising 60 PD patients that were administered a daily probiotic for 12 weeks found that the probiotic reduced the risk of PD progression [191]. In this regard, supplementation, involving probiotics, has shown a wide range of positive impacts on metabolic pro iles/ symptoms, thereby having the potential to signi icantly bene it PD patients [191].…”

Section: Parkinson's Disease and Nutrientsmentioning

confidence: 99%

“…A study comprising 60 PD patients that were administered a daily probiotic for 12 weeks found that the probiotic reduced the risk of PD progression [191]. In this regard, supplementation, involving probiotics, has shown a wide range of positive impacts on metabolic pro iles/ symptoms, thereby having the potential to signi icantly bene it PD patients [191]. Foods with high prebiotic content include artichokes, bamboo shoots, asparagus, bananas, barley, black pepper, chicory coffee, dark beets, chocolate, broccoli, fennel root, endive, mustard greens, Jerusalem artichokes, ginger, jicama, tomatoes, yacón, leeks, and legumes [98].…”

Section: Parkinson's Disease and Nutrientsmentioning

confidence: 99%

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Madireddy¹,

Madireddy²

2019

J Neurosci Neurol Disord

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Vitamin E Antioxidant, Neuroprotection Vitamin E is a scavenger of several ROS and serves to reduce their reactivity and toxicity. It offers protection from the propagative damage of ROS by inhibiting the oxidative modifi cation of lipoproteins AD [74-79,82-86] PD [175-177,79] ALS [193,217,218] Vitamin C Antioxidant, Neuroprotection Vitamin C is an excellent antioxidant, suitable in reducing ROS levels, lipid peroxidation, and oxidative stress. It is also useful in regenerating other antioxidants. AD [81,82,75,77,79] PD [166-168] ALS [213,214] Vitamin D Antioxidant Neuroprotection Vitamin D prevent oxidative stress, lower the production of free radicals, and reduce neurotoxicity through the enhancement of autophagy signaling pathways AD [74-78,30,16,80] PD [157-159,169-174] ALS [215,216] Vitamin A Antioxidan Vitamin A prevent the formation of Aβ plaques AD [16,30,74-78] Vitamin B Antioxidant Neuroprotection Vitamin B perform antioxidant and neuroprotective functions AD [88-90] PD [157-159,162-165] HD [105] Curcumin Antioxidant Anti-infl ammatory Neuroprotection Curcumin is a scavenger of free radicals and reduces mitochondrial disfunction. AD [100,101] Omega−3 fatty acids Antioxidant Anti-infl ammatory Omega-3 fatty acids reduce ROS formation acting as free radical scavengers.

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“…Parkinson's and Alzheimer's diseases. There is an urgent need for a great investment in clinical trials in these entities [106][107][108][109][110]. [111].…”

Section: Psychobiotics -New Kids On the Blockmentioning

confidence: 99%

Microbiome – The Missing Link in the Gut-Brain Axis. The Focus on Gastrointestinal and Mental Health

Skonieczna-Żydecka¹,

Marlicz²,

Misera³

et al. 2018

Preprint

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The central nervous system (CNS) and the human gastrointestinal (GI) tract communicate through the gut-brain axis (GBA). Such communication is bi-directional and involves neuronal, endocrine and immunological mechanisms. The scientific data are mounting that gut microbiota is a source of a number of neuroactive and immunocompetent substances, which shape the structure and function of brain regions involved in control of emotions, physical activity and cognition. Most of GI maladies are associated with altered transmission within the GBA and influenced both by genetic and environmental factors. Current treatment protocols widely advocated for the treatment of GI disorders may positively or adversely affect the composition of intestinal microbiota with diverse impact on therapeutic outcome. The alterations of gut microbiota have been associated with mood and depressive disorders. and mental health is frequently altered in the course of many GI and non-GI ailments. Deregulation of the GBA may constitute a grip point for the development of diagnostic tools and personalized microbiota-based therapy. For example next generation sequencing (NGS) offers detailed analysis of microbiome footprints in patients with mental and GI disorders. Psychobiotics are new class of beneficial bacteria, with documented efficacy in the treatment of gut-brain axis disorders.

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Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

Cited by 293 publications

References 25 publications

Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Microbiome – The Missing Link in the Gut-Brain Axis. The Focus on Gastrointestinal and Mental Health

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Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

Cited by 293 publications

References 25 publications

Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Microbiome &ndash; The Missing Link in the Gut-Brain Axis. The Focus on Gastrointestinal and Mental Health

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Product

Resources

About

Microbiome – The Missing Link in the Gut-Brain Axis. The Focus on Gastrointestinal and Mental Health