Clinical and Microbiological Characteristics of Chryseobacterium indologenes Bacteremia

Abstract

C. indologenes isolates are resistant to multiple antibiotics, with newer fluoroquinolones and trimethoprim-sulfamethoxazole possibly representing the most appropriate antimicrobial agents to treat infections caused by this pathogen. However, the pathogenicity and factors of virulence for C. indologenes remain unclear, with our study revealing favorable outcomes of C. indologenes bacteremia. Epidemiological surveillance of this organism in Taiwan and extensive worldwide surveillance programs are required.

Chryseobacterium indolegenes infection in a patient with chronic obstructive pulmonary disease

“…and prolonged exposure to broad spectrum antibiotics (5,10). Despite the fact that our patient had no history of hospitalization for at least one year, pneumonia cause was found to be C. indolegenes.…”

“…It was reported that C. indologenes are responsible from various clinical conditions, such as bacteremia, sepsis, pneumonia, shunt infection, urinary tract infection, infection of the central nervous system (10)(11)(12)(13)(14)(15). It was reported that some underlying conditions such as indwelling devices, malignancies, hypertension diabetes mellitus lead to severe infections in hospitalized patients (10). Although it is rising importance in healthcare associated infections, there is no guideline for management of C. indologenes infections (3,4).…”

Antimicrobial activity of cinnamaldehyde, vanillin and <i>Kigelia Africana</i> fruit extracts against fish-associated <i>Chryseobacterium</i> and <i>Myroides</i> spp. isolates

“…is hampered by the breadth of resistance to extended-spectrum penicillins, first-and second-generation cephalosporins, ceftriaxone, aminoglycosides, aztreonam, chloramphenicol, erythromycin, imipenem, meropenem and ticarcillin-clavulanate (Lin et al, 2010). The treatment of Myroides infection is also often difficult, since most strains are resistant to β-lactams, including aztreonam and carbapenems, and exhibit variable susceptibility to aminoglycosides, quinolones, and sulfamethoxazole (Benedetti et (Table 3).…”

Recurrent Port Infection Due to Chryseobacterium Indologenes

“…Lin et al [10] recently reported 16 bacteremia episodes due to C. indologenes, and all of the patients had underlying conditions including mechanical ventilation, neoplasm, chemotherapy, chronic heart and lung diseases, chronic bed-ridden status and indwelling catheters. Hsueh et al [3] also found that most cases involved nosocomial pneumonia and catheter-related bacteremia [3].…”

“…Although Hsueh et al did not recommend the removal of all indwelling catheters, Lin et al [10] suggested that catheters be removed when a catheter-related infection occurs due to C. indologenes. Our patient also had a neoplasm and an indwelling catheter (i.e., a port).…”