Clinical and microbiological characteristics of dysbiotic changes in the oral and oropharyngeal mucosa

Крюков, И.; Кунельская, Л.; Гуров, В.; Изотова, Н.; Старостина, Елизавета Алексеевна; Лапченко, С.

doi:10.21518/2079-701x-2016-6-32-35

Cited by 4 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Анатомо-физиологическая близость полости рта непосредственно с пищеварительным трактом создает предпосылки вовлечения собственно слизистой оболочки рта в хронический патологический процесс при классических и опосредованных кислотозависимых заболеваниях желудочно-кишечного тракта [6][7][8][9][11][12][13][14].…”

Section: актуальностьunclassified

Features of oral microbiota composition in patients with oral mucosal disease associated with classical and mediated acid-related gastrointestinal disorders

et al. 2022

View full text Add to dashboard Cite

Relevance. The authors established that classical and mediated acid-related gastrointestinal disorders affect the change in microbiota and the development of mucosal disease.Purpose. The study aimed to investigate the characteristics of oral microbiota in patients with mucosal disease associated with classical and mediated acid-related gastrointestinal disorders.Materials and methods. The study included 58 patients with the oral mucosal disease associated with chronic gastritis and duodenitis, pancreatitis secondary to gallstones associated with stomach hypersecretion. The comparison group consisted of 25 subjects without oral mucosal disease, with previously diagnosed acid-related gastrointestinal disorders and eradicated Helicobacter pylori as of the clinical examination time.Results. The study detected a pH shift towards the acidic end of the scale in the oral fluid samples of subjects with oral aphthous ulcers compared to the group without oral mucosal disease (comparison group) (p < 0.001). The composition ratio of the studied microbiota from the surface of the oral aphthous ulcers in the main groups showed an increase in the number of Candida spp. by 1.7 and 3.2 times (p > 0.2), Enterobacteriaceae spp. – 1.7 and 2.6 times, (p > 0.2), Actinobacillus spp. – 1.4 and 2.0 times (p > 0.2), Staphylococcus spp. – 1.3 and 1.5 times (p > 0.2), Enterococcus spp. – 2.6 and 3.5 times (p > 0.2), and a decrease in Neisseria spp. by 1.9 and 3.1 times (p > 0.2). The studied microbiota of main group II (PSG associated with SH) demonstrated a significant increase in the above species, p < 0.05, and a significant decrease in Neisseria spp., at p<0.05.Conclusion. The studied aphthous ulcer surface microbiota, obtained from subjects with pancreatitis secondary to gallstones associated with stomach hypersecretion, revealed a significant overrepresentation of Gram +, Gram– facultatively anaerobic and opportunistic microorganisms contributing to the aggravation of the oral mucosal disease clinical features.

show abstract

Section: актуальностьunclassified

Features of oral microbiota composition in patients with oral mucosal disease associated with classical and mediated acid-related gastrointestinal disorders

et al. 2022

View full text Add to dashboard Cite

show abstract

Microbiological Aspects of the Etiology of Jaw Osteomyelitis

Fayzullina,

Mirsaeva

2023

Actual Problems in Dentistry

View full text Add to dashboard Cite

Background. Difficulties in the treatment of the inflammatory process of bone tissue focus the attention of researchers and practitioners on the early identification of pathogens of osteomyelitis, which is the key to successful treatment of the disease. According to publications cited in The Cocrane Library database, the epidemiology and etiological structure of osteomyelitis has undergone significant changes in recent years. The aim of the review is to provide up-to-date information on etiologically significant representatives of the microbial flora in osteomyelitis of the jaws. Methodology. Search work was carried out using international scientific databases PubMed, ScienceDirect, Scopus, Cochrane Collaboration, Elsevier, as well as electronic catalogs Elibrary and Cyberleninka on microbiological aspects of the etiology of osteomyelitis of the jaws. Results. A review of publications has demonstrated the dominant position of representatives of the genus Staphylococcus in the etiological spectrum of chronic post-traumatic osteomyelitis. The predominant pathogen is S. aureus. The proportion of infections mediated by S. epidermidis, S. Saprophyticus is, on average, about 25% of cases. The proportion of representatives of the gram-negative flora Escherichia, Klebsiella, Enterobacter, Citrobacter, Proteus, Providencia, Serratia reaches 23% of cases. According to the above information, the causative agents of gram-negative infections make up 1/5 of the etiological spectrum of chronic osteomyelitis. Pathogenic nosocomial strains of P. aeruginosa are also involved in the formation of chronic inflammation in osteomyelitis. According to the results of published studies, more than a third of cases of chronic osteomyelitis are mediated by microbial associations. The latter are dominated by S. aureus, S. epidermidis and, less frequently, E. faecalis. At the same time, dynamic analysis showed the variability of the microbial composition of associations, which determines additional difficulties in choosing the actual etiotropic therapy and may cause further progression of the pathological process. Conclusions. Implementation of effective methods of therapy requires new informative diagnostic approaches. However, the sensitivity of routine microbiological analyzes is not high enough. At the present stage, the diagnostic value of molecular genetic methods based on the polymerase chain reaction has been recognized.

show abstract

The influence of nasal and oropharyngeal mucosal dysbiosis on the condition of the middle ear in children with congenital cleft palate

Andreeva¹,

Mamleev

Marapov

et al. 2022

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

Disturbance of the microbiocenosis of the nasal cavity and oropharynx in children with congenital cleft palate presents serious therapeutic difficulties. Pathobionts colonizing the upper respiratory tract and chronic adenoiditis pose a threat of acute purulent otitis media and chronic otitis media with effusion. The authors studied nasal and oropharyngeal mucosal dysbiosis in patients before elective uranoplasty and the effect of dysbiotic manifestations on the condition of the middle ear in the postoperative period. The results of microbiological examination of 80 swabs from the nasal cavity and oropharynx in patients with congenital cleft palate were analyzed. Among the culture-positive results in patients in clinical and laboratory remission of ENT-infections dysbiosis of 2–3 degrees prevails, the presence of bacterial-bacterial and bacterial-fungal associations is often noted, the predominance of gram-negative microflora is noted. There was an increase in the frequency of perforations of the tympanic membrane in the presence of bacterial and fungal associations, the appearance of retraction pockets in the presence of gram-negative microflora, the relationship between grade 3 dysbiosis and the appearance of purulent otitis media after uranoplasty were revealed.Conclusion. Disturbance of microbiocenosis in patients with congenital cleft palate before uranoplasty requires the inclusion of a microbiological study in the preoperative preparation schedule and a personalized approach to perioperative antibiotic prophylaxis.

show abstract

Clinical and microbiological characteristics of dysbiotic changes in the oral and oropharyngeal mucosa

Cited by 4 publications

References 2 publications

Features of oral microbiota composition in patients with oral mucosal disease associated with classical and mediated acid-related gastrointestinal disorders

Features of oral microbiota composition in patients with oral mucosal disease associated with classical and mediated acid-related gastrointestinal disorders

Microbiological Aspects of the Etiology of Jaw Osteomyelitis

The influence of nasal and oropharyngeal mucosal dysbiosis on the condition of the middle ear in children with congenital cleft palate

Contact Info

Product

Resources

About