Clinical and microbiological efficacy of chlorine dioxide in the management of chronic atrophic candidiasis: an open study

Mohammad, Atif; Giannini, Peter J.; Preshaw, Philip M.; Alliger, Howard

doi:10.1111/j.1875-595x.2004.tb00272.x

Cited by 26 publications

(31 citation statements)

References 16 publications

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“…There have been few studies using CloSYSII oral spray as a denture cleanser in the literature. The efficacy of topical 0.8% chlorine dioxide in the management of chronic atrophic candidiasis was demonstrated by Mohammad, et al 25 (2004), who stated that ClO 2 provided a safe and clinically effective option in the management of chronic atrophic candidiasis.…”

Section: Discussionmentioning

confidence: 99%

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In vivo efficacy of alkaline peroxide tablets and mouthwashes on Candida albicans in patients with denture stomatitis

et al. 2010

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ObjectiveEffective cleaning of dentures is important for the maintenance of good oral hygiene for denture stomatitis patients. The in vivo efficacy of three different brands of alkaline peroxide tablets (Polident, Efferdent, and Fittydent) and two mouthwashes (CloSYS II and Corsodyl) to eliminate Candida albicans on dentures was evaluated in this in vivo study.Material and methodsNinety denture wearers with clinical evidence of denture stomatitis were randomly divided into 5 test groups and 1 control group. Each group was further divided into three subgroups in which the dentures were subjected to 15-, 30-, and 60-min disinfection procedures. The dentures of each test group were treated with one of the cleaners, while those of the control group were treated with distilled water. Swab samples from the palatal surfaces (2 cm x 2 cm template delimited area) of the upper dentures were obtained before and after 15, 30, and 60 min periods of cleaner use and examined mycologically.ResultsThe reduction in the number of colony-forming units (CFU) of C. albicans before, and after 15, 30, and 60 min of use of CloSYS II and Corsodyl was significantly greater than that of the control group (p<0.05). Moreover, there was no statistically significant difference (p>0.05) among Polident, Efferdent and the control group in any of the treatment periods. Dentures treated with Fittydent appeared to have a significantly greater reduction in the number of Candida spp. only after 60 min of treatment.ConclusionsThe results of this study showed that the use of mouthwashes significantly reduced the number of microorganisms on dentures.

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Section: Discussionmentioning

confidence: 99%

“…after dental surgery 5,9,10,14 . The clinical and microbiological efficacy of chlorine dioxide (ClO 2 ) as a topical antiseptic and disinfectant agent also used for the treatment of chronic atrophic candidiasis in geriatric patients has been assessed 25 .…”

Section: Introductionmentioning

confidence: 99%

In vivo efficacy of alkaline peroxide tablets and mouthwashes on Candida albicans in patients with denture stomatitis

et al. 2010

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“…It is readily soluble in water forming a light clear yellow-colored solution in which it can remain intact for considerable periods of time. Oral rinses containing ClO 2 are now utilized in dental practices as a topical antiseptic for the oral cavity or for dentures [21,35,36]. Previous studies have suggested that ClO 2 and ClO 2 - are chemically reactive oxidants with powerful reducing capacity on VSCs.…”

Section: Discussionmentioning

confidence: 99%

Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial

Shinada

Ueno

Konishi

et al. 2010

Trials

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BackgroundPrevious research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2). Its clinical efficacies on oral malodor have been evaluated and reported only in short duration trials, moreover, no clinical studies have investigated its microbiological efficacies on periodontal and malodorous bacteria. Thus, the aim of this study was to assess the inhibitory effects of a mouthwash containing ClO2 used for 7 days on morning oral malodor and on salivary periodontal and malodorous bacteria.Methods/DesignA randomized, double blind, crossover, placebo-controlled trial was conducted among 15 healthy male volunteers, who were divided into 2 groups. Subjects were instructed to rinse with the experimental mouthwash containing ClO2 or the placebo mouthwash, without ClO2, twice per day for 7 days. After a one week washout period, each group then used the opposite mouthwash for 7 days. At baseline and after 7 days, oral malodor was evaluated with Organoleptic measurement (OM), and analyzed the concentrations of hydrogen sulfide (H2S), methyl mercaptan (CH3SH) and dimethyl sulfide ((CH3)2S), the main VSCs of human oral malodor, were assessed by gas chromatography (GC). Clinical outcome variables included plaque and gingival indices, and tongue coating index. The samples of saliva were microbiologically investigated. Quantitative and qualitative analyses were performed using the polymerase chain reaction-Invader method.Results and DiscussionThe baseline oral condition in healthy subjects in the 2 groups did not differ significantly. After rinsing with the mouthwash containing ClO2 for 7 days, morning bad breath decreased as measured by the OM and reduced the concentrations of H2S, CH3SH and (CH3)2S measured by GC, were found. Moreover ClO2 mouthwash used over a 7-day period appeared effective in reducing plaque, tongue coating accumulation and the counts of Fusobacterium nucleatum in saliva. Future research is needed to examine long-term effects, as well as effects on periodontal diseases and plaque accumulation in a well-defined sample of halitosis patients and broader population samples.Trial registrationClinicalTrials.gov NCT00748943

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“…Oral rinses containing ClO 2 are now utilized in dental practices as a topical antiseptic for oral cavity and dentures. 21,22 Previous studies have suggested that ClO 2 and chlorite anion are powerful bactericidal agents to most of the periodontogenic microorganisms. [23][24][25] It was also shown to be effective in treating halitosis, plaque, and gingivitis.…”

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confidence: 99%

Effect of Aloe vera, chlorine dioxide, and chlorhexidine mouth rinses on plaque and gingivitis: A randomized controlled trial

Yeturu

Acharya

Urala

et al. 2016

Journal of Oral Biology and Craniofacial Research

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Clinical and microbiological efficacy of chlorine dioxide in the management of chronic atrophic candidiasis: an open study

Abstract: Within the limitations of this pilot study, the effectiveness of topical chlorine dioxide (0.8%) in the management of chronic atrophic candidiasis was demonstrated. ClO2 provided a safe and clinically effective option in the management of chronic atrophic candidiasis.

Cited by 26 publications

References 16 publications

In vivo efficacy of alkaline peroxide tablets and mouthwashes on Candida albicans in patients with denture stomatitis

In vivo efficacy of alkaline peroxide tablets and mouthwashes on Candida albicans in patients with denture stomatitis

Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial

Effect of Aloe vera, chlorine dioxide, and chlorhexidine mouth rinses on plaque and gingivitis: A randomized controlled trial

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