Clinical and Molecular Aspects of Vitiligo Treatments

Bishnoi, Anuradha; Parsad, Davinder

doi:10.3390/ijms19051509

Cited by 62 publications

(66 citation statements)

References 90 publications

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“…Patients who have vitiligo experience low self‐esteem. The disease negatively affects quality of life . Vitiligo has a complex pathogenesis, and the precise etiology is still unclear.…”

Section: Introductionmentioning

confidence: 99%

“…The disease negatively affects quality of life. [1][2][3] Vitiligo has a complex pathogenesis, and the precise etiology is still unclear. It was suggested that different factors especially genetic influences, stress, autoimmune predisposition, dysfunctional biochemical pathway, and trauma may act synergistically in disappearance of melanocytes from the skin.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment

Ebrahim

Albalate

2020

J of Cosmetic Dermatology

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Background Combination therapies have reported to augment the repigmentation in vitiligo. Microneedling (Mn) facilitates drug delivery across the skin barrier. Objective To evaluate and compare the efficacy and safety of Mn combined with tacrolimus vs Mn alone or tacrolimus 0.1% ointment for treatment of localized and stable vitiligo. Patients and Method Ninety patients with vitiligo were randomized into three groups: group I received microneedling with tacrolimus, group II microneedling only both at 2 weeks interval for twelve sessions, and group III applied tacrolimus ointment 0.1% twice daily for 6 months. Skin biopsies were taken at baseline and after treatment. Results The overall improvement (76.6%) was significantly higher in the combined group compared with other groups. Repigmentation was excellent in 66.6 of group I vs 33.3% in the other two groups (P .03). A highly significant improvement of the extremities was observed in the combined group than in the other groups (P < .001). A fewer number of sessions have reported in the combined group (I) than in the microneedling group (II; P < .001). Immunohistochemical results showed a significantly higher expression of HMB‐45 in group I than in other two groups (P .04). Side effects were mild and tolerable in all groups. Conclusion The combination group has shown promising results over the other two groups.

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“…Patients who have vitiligo experience low self‐esteem. The disease negatively affects quality of life . Vitiligo has a complex pathogenesis, and the precise etiology is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment

Ebrahim

Albalate

2020

J of Cosmetic Dermatology

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“…It is the most common depigmentation disorder, affecting approximately 0.5–2.0% of the population, with no sex or race predilection (Ezzedine, Eleftheriadou, Whitton, & van Geel, ). Several theories have been suggested to explain the pathogenesis of vitiligo and the mechanisms finally leading to the loss of functional melanocytes from the epidermis (Bishnoi & Parsad, ).…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of interrupted versus continuous narrowband ultraviolet B phototherapy in nonsegmental vitiligo treatment: A prospective randomized comparative study

Anbar

Mohammed

Mohamed

et al. 2019

Dermatologic Therapy

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Phototherapy is the pillar of vitiligo treatment. One of its main obstacles is noncompliance. It was noticed that patients continue to repigment even after stopping sessions, so the idea of interrupted phototherapy emerged. To evaluate the effectiveness of interrupted versus continuous NB‐UVB in nonsegmental vitiligo treatment. A prospective randomized comparative study of 23 patients with bilateral, nonsegmental vitiligo with no age or sex limits. All patients were treated with NB‐UVB phototherapy for 1 month, after which one side of the body received continuous therapy (Side A) and the other received an interrupted course (Side B) for a total of 6 months. Two more groups of 10 patients were enrolled to exclude the systemic effect of NB‐UVB. One group received continuous NB‐UVB treatment, and the other received interrupted courses for 6 months. Evaluation of the results was performed clinically, by digital photography, planimetry and Vitiligo Area Scoring Index (VASI) prior to and 3 and 6 months after treatment. There was a significant clinical improvement in Group 1 compared to baseline (p < .05). However, there was no significant difference between the sides with regards to the clinical evaluation, point counting, and VASI scores (p > .05). When comparing the other two groups, there was a significant clinical improvement in each group after 6 months of treatment compared to baseline (p < .05), while there was no significant difference between them (p > .05). The current study suggests that interrupted NB‐UVB phototherapy is a good alternative to continuous treatment with improved patient compliance, fewer side effects, and a lower cost of treatment.

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“…Due to loss of melanocytes in individuals affected by vitiligo, one can also expect an increased incidence of non-melanoma cancer and actinic keratose (Zhang et al, 2016). Arresting the progression of lesions and repigmentation of formed lesions remains to be a crucial strategy for treatment (Bishnoi & Parsad, 2018). AK-STAT inhibitors have demonstrated promising outcomes in the treatment of vitiligo, including repigmentation in topical applications.…”

Section: Introductionmentioning

confidence: 99%

VIRdb: a comprehensive database for interactive analysis of genes/proteins involved in the pathogenesis of vitiligo

Srivastava

Choudhury

Talwar

et al. 2020

PeerJ

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Vitiligo is a chronic asymptomatic disorder affecting melanocytes from the basal layer of the epidermis which leads to a patchy loss of skin color. Even though it is one of the neglected disease conditions, people suffering from vitiligo are more prone to psychological disorders. As of now, various studies have been done in order to project auto-immune implications as the root cause. To understand the complexity of vitiligo, we propose the Vitiligo Information Resource (VIRdb) that integrates both the drug-target and systems approach to produce a comprehensive repository entirely devoted to vitiligo, along with curated information at both protein level and gene level along with potential therapeutics leads. These 25,041 natural compounds are curated from Natural Product Activity and Species Source Database. VIRdb is an attempt to accelerate the drug discovery process and laboratory trials for vitiligo through the computationally derived potential drugs. It is an exhaustive resource consisting of 129 differentially expressed genes, which are validated through gene ontology and pathway enrichment analysis. We also report 22 genes through enrichment analysis which are involved in the regulation of epithelial cell differentiation. At the protein level, 40 curated protein target molecules along with their natural hits that are derived through virtual screening. We also demonstrate the utility of the VIRdb by exploring the Protein–Protein Interaction Network and Gene–Gene Interaction Network of the target proteins and differentially expressed genes. For maintaining the quality and standard of the data in the VIRdb, the gold standard in bioinformatics toolkits like Cytoscape, Schrödinger’s GLIDE, along with the server installation of MATLAB, are used for generating results. VIRdb can be accessed through “http://www.vitiligoinfores.com/”.

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Clinical and Molecular Aspects of Vitiligo Treatments

Cited by 62 publications

References 90 publications

Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment

Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment

Clinical evaluation of interrupted versus continuous narrowband ultraviolet B phototherapy in nonsegmental vitiligo treatment: A prospective randomized comparative study

VIRdb: a comprehensive database for interactive analysis of genes/proteins involved in the pathogenesis of vitiligo

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