Clinical and molecular diagnosis of Acanthamoeba keratitis in contact lens wearers in southern Brazil reveals the presence of an endosymbiont

Santos, Denise Leal dos; Virginio, Veridiana Gomes; Berte, Francisco Kercher; Lorenzatto, Karina Rodrigues; Marinho, Diane Ruschel; Kwitko, Sérgio; Locatelli, Claudete Inês; Freitas, Eduarda Correa; Rott, Marilise Brittes

doi:10.1007/s00436-022-07474-y

Cited by 12 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…“All CA count”number of unique CA proteins for that organism (possessing a UniPROT protein ID). “Unique CA count”from the “All CA count” proteins, how many are left after reducing to a max 80% similarity. b Refrence . c Reference . d Reference . e Reference . f Reference . g Reference . h Reference . …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel Drug Screening Assay for Acanthamoeba castellanii and the Anti-Amoebic Effect of Carbonic Anhydrase Inhibitors

Haapanen,

Barker,

Carta

et al. 2023

J. Med. Chem.

View full text Add to dashboard Cite

Acanthamoeba castellanii is an amoeba that inhabits soil and water in every part of the world. Acanthamoeba infection of the eye causes keratitis and can lead to a loss of vision. Current treatment options are only moderately effective, have multiple harmful side effects, and are tedious. In our study, we developed a novel drug screening method to define the inhibitory properties of potential new drugs against A. castellanii in vitro. We found that the clinically used carbonic anhydrase inhibitors, acetazolamide, ethoxzolamide, and dorzolamide, have promising antiamoebic properties.

show abstract

Section: Introductionmentioning

confidence: 99%

“…“Unique CA count”—from the “All CA count” proteins, how many are left after reducing to a max 80% similarity. b Refrence ( 39 ). c Reference ( 40 ).…”

Section: Introductionmentioning

confidence: 99%