Clinical and Molecular Perspectives of Reparative Dentin Formation

Song, Minju; Yu, Bo; Kim, Sol; Hayashi, Marc; Smith, C. Page; Sohn, Seong-Wook; Kim, Euiseong; Lim, James; Stevenson, Richard G.; Kim, Reuben H.

doi:10.1016/j.cden.2016.08.008

Cited by 58 publications

(32 citation statements)

References 119 publications

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“…A perfect joint between each material is capable of spreading the stress of the occlusal forces [11]. Biodentine ® is a dentine substitute with excellent biocompatibility, bioactivity, and biomineralization properties with great results when used in pulp capping procedures, as it as shown that this biomaterial induces TGF-β1 secretion from dental pulp cells [16,23,[28][29][30]. Han and Okiji [31] demonstrated the biomineralization properties of Biodentine ® , allowing the uptake of calcium and silicon in the adjacent dentine in contact with Biodentine ® .…”

Section: Discussionmentioning

confidence: 99%

Shear Bond Strength of Nanohybrid Composite to Biodentine with Three Different Adhesives

et al. 2019

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Biodentine® is a bioactive dentin coating widely used for dental restoration; however, its adhesion to the substrate could limit its clinical success. The aim of this study was to evaluate the shear bond strength (SBS) between Biodentine® and a composite resin, using different types of adhesive. In total, 120 acrylic blocks with a central hole were prepared. They were fully filled with Biodentine®, and divided into two time groups: 12 min (n = 60) and 24 h (n = 60); each group was subdivided into four groups according to the adhesive: three-step etch and rinse (3-E&R) (n = 15), two-step etch and rinse (n = 15), and a universal adhesive subdivided into two groups, two-step etch and rinse (n = 15) and one-step self-etch adhesive system (n = 15). After adhesive application, the composite was applied and stored at 100% humidity, at 37 °C, for 24 h, before the SBS test. Data were analyzed with one-way ANOVA, Fisher post hoc test, and Kolmogorov–Smirnov test. The 12-min group showed statistically significant differences (p = 0.009), with the highest values of adhesion for 3-E&R. No statistically significant differences were observed for the 24-h group (p = 0.813) and between adhesive systems (p = 0.071) regardless of adhesion time. Higher adhesion values were found at 24 h. It is essential to consider the longest setting time for Biodentine®. In terms of adhesive, 3-E&R had the highest adhesion values.

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Section: Discussionmentioning

confidence: 99%

Shear Bond Strength of Nanohybrid Composite to Biodentine with Three Different Adhesives

et al. 2019

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“…During this process, the damaged odontoblasts are replaced by newly differentiated odontoblast cells [1,2]. Migration of progenitor cells to the lesion site and subsequent proliferation and differentiation of these cells into odontoblasts occurs [3,4,5]. Thus, when a dental pulp tissue exposition occurs, reparative dentinogenesis can be induced by pulp capping to maintain the vitality and function of the pulp.…”

Section: Introductionmentioning

confidence: 99%

Biodentine™ Boosts, WhiteProRoot®MTA Increases and Life® Suppresses Odontoblast Activity

et al. 2019

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(1) Background: When pulp exposure occurs, reparative dentinogenesis can be induced by direct pulp capping to maintain the vitality and function of the tissue. The aim of this work was to assess the cytotoxicity and bioactivity of three different direct pulp capping materials, calcium hydroxide (Life®), mineral trioxide aggregate (WhiteProRoot®MTA) and calcium silicate (Biodentine™), in an odontoblast-like mouse cell line (MDPC-23). (2) Methods: Metabolic activity was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (MTT)assay, viability by the sulforhodamine B (SRB) assay, and the type of death and cell cycle analysis by flow cytometry. Alkaline phosphatase was evaluated by polymerase chain reaction (PCR), and dentin sialoprotein expression was assessed by immunocytochemistry. Mineralization was determined by the Alizarin Red S colorimetric assay and quantified by spectrophotometry. (3) Results: Life® induced a decrease in metabolic activity and viability, which is associated with an increase cell death. WhiteProRoot®MTA and Biodentine™ induced similar effects in cytotoxicity assays, with an increase in the expression of dentin sialoprotein (DSP) and formation of mineralized deposits, especially with Biodentine™. (4) Conclusions: The results of WhiteProRoot®MTA confirm its indication for these therapies, justifying its recognition as the “gold standard”. Biodentine™ may be an alternative, since they promote the same cellular response that mineral trioxide aggregate (MTA) does.

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“…However, introduction of newer bioactive materials such as mineral trioxide aggregate (MTA) and Biodentine helped surpass the demerits of calcium hydroxide such as internal resorption, nonadherence to dentin, degradation over time, tunnel defects, and poor sealing ability. [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

In vivo outcomes of indirect pulp treatment in primary posterior teeth: 6 months' follow-up

Chauhan¹,

Dua²,

Saini³

et al. 2018

Contemp Clin Dent

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Background:Indirect pulp treatment (IPT) is a minimally invasive procedure based on the application of a protective liner on the affected dentin, thereby preserving the pulp vitality.Aim:This study aims to evaluate and compare the clinical and radiographic outcomes of IPT when a layer of calcium hydroxide (Dycal), mineral trioxide aggregate (MTA), or Biodentine was placed over the affected dentin in primary molars.Materials and Methods:A clinical trial with sample size of 45 primary molars between the age group of 4–9 years, of which 15 teeth were considered, each for Group I (Dycal), Group II (MTA), and Group III (Biodentine). Measurements on digitized radiographs were made at baseline, 3, and 6 months using Corel Draw software.Results:One-way ANOVA and post hoc tests indicated a statistically significant difference in dentin thickness (P < 0.05) in all the groups. Within Group I, the thickness of dentin was 0.066 ± 0.009 mm at 3 months and 0.099 ± 0.011 mm at 6 months. In Group II, 0.081 ± 0.010 mm at 3 months and 0.123 ± 0.016 mm at 6 months. In Group III, 0.102 ± 0.021 mm at 3 months and 0.154 ± 0.022 mm at 6 months.Conclusions:Clinically, 100% success rate was observed in all the groups whereas radiographically, Biodentine was superior to both the groups.

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Clinical and Molecular Perspectives of Reparative Dentin Formation

Cited by 58 publications

References 119 publications

Shear Bond Strength of Nanohybrid Composite to Biodentine with Three Different Adhesives

Shear Bond Strength of Nanohybrid Composite to Biodentine with Three Different Adhesives

Biodentine™ Boosts, WhiteProRoot®MTA Increases and Life® Suppresses Odontoblast Activity

In vivo outcomes of indirect pulp treatment in primary posterior teeth: 6 months' follow-up

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