Clinical and morphological characteristics of skin and subcutaneous fat damage after surgical treatment and radiation therapy in patients with breast cancer (literature review)

Топузов, Э Э; Агишев, Т Т; Bozhok, A.A.; Дашян, Г. А.; Садыгова, С Н; Аршба, Э. А.; Приходько, У. В.

doi:10.17650/1994-4098-2017-13-1-25-33

Cited by 6 publications

(11 citation statements)

References 13 publications

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“…Лучевая терапия остается одним из эффективных и значимых методов лечения злокачественных заболеваний, в частности рака молочной железы (РМЖ) [1,2]. Понимание толерантности доз ионизирующего излучения к различным органам и тканям, улучшение сроков режима, а также совершенствование источников облучения позволяют добиться существенного противоопухолевого эффекта.…”

Section: Introductionunclassified

“…В настоящее время в мире поздние лучевые повреждения возникают у 5 % от числа всех пациентов, перенесших лучевую терапию, однако, по данным некоторых исследователей, формирование этой патологии в России может превышать 10-15 % [1,3,4].…”

Section: Introductionunclassified

“…Патогенез РИФ в современной литературе рассматривается с нескольких позиций, согласно одной из них основной причиной патогенеза РИФ служат лучевые повреждения сосудов под воздействием ионизирующего излу чения, когда в наибольшей степени повреждается эндотелий капилляров. Это приводит сначала к функциональным нарушениям микроциркуляции и гипоксии облученной ткани, а впоследствии к морфологическим изменениям в клетках и формированию поздних проявлений лучевого воздействия в виде фиброза и склероза, которые сами непосредственно влияют на нарастание гипоксии в пораженных участках, образуя порочный круг [1,[5][6][7]9].…”

Section: Introductionunclassified

“…В дальнейшем отмечаются разрыв базальной мембраны, нарушение местного кровотока и изменения в стенках сосудов. Если суммарная поглощающая доза излучения меньше уровня «толерантной дозы» облучаемой ткани, то патологический процесс постепенно стихает, а количество стволовых клеток восстанавливается с последующей дифференцировкой [1,10,11].…”

Section: Introductionunclassified

“…Фибробласты играют ключевую роль в заживлении ран путем осаждения и ремоделирования коллагеновых волокон, а в облученной ткани структура этих волокон становится неорганизованной (за счет возможного нарушения регуляции матричных металлопротеиназ). По утверждению ряда авторов, образование интерстициального коллагена I, III и V типов индуцированными облучением постмитотическими фибробластами идет в 5-8 раз активнее, чем у их клеток-предшественниц [1,12,13,17].…”

Section: Introductionunclassified

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Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer

Топузов

Агишев

Fedorov

et al. 2018

HERALD of North-Western State Medical University named after I.

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Late radiation injury in the form of radiation-induced fibrosis is one of the many complications of radiation therapy.In current literature, pathogenesis of radiation-induced fibrosis is considered from several angles. According to one of the hypotheses, the main cause of pathogenesis of radiation-induced fibrosis is damage of the blood vessels caused by radiation. Another hypothesis insists that radiation causes depletion of specific cell populations in the irradiated area, reducing the number of stem cells (mostly, fibroblasts). (For citation: Topuzov EE, Agishev TT, Fedorov КА, et al. Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer. Herald of North-Western State Medical University named after I.I. Mechnikov. 2018;10(2):58-63. doi: 10.17816/mechnikov201810258-63).

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Section: Introductionunclassified

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Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer

Топузов

Агишев

Fedorov

et al. 2018

HERALD of North-Western State Medical University named after I.

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Characteristics of Skin Electrical Conductance in Patients With Breast Cancer and High Risk of Radiation Therapy-Related Complications

Kulinich

Prokhorova

Hladkykh

2021

EUMJ

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Background. Radiation therapy (RT) is one of the main methods of treating cancer, including breast cancer (BC). This is one of the most knowledge-intensive medical industries, which is based on the latest advances in radiobiology, chemistry, radiation physics, engineering and others. Effective PT involves the use of fairly high doses of radiation, which is what determines the success of comprehensive treatment, in particular the increase in the number of patients who survived 5 years or more. In turn, the increase in survival after a course of combination treatment leads to an increase in the absolute number of patients with adverse treatment outcomes, including radiation-related complications (RC). The aim of the work was to characterize the changes in the skin electrical conductance in patients with breast cancer and an increased risk of RC. Materials and methods. The study was conducted on the basis of the clinic of the Grigoriev Institute of Medical Radiology and Oncology of NAMS of Ukraine. To study the skin electrical conductance, 16 patients with BC with an increased risk of RC were selected, with a mean age of 53.8 ± 3.7 (95% CI: 46.6–61.0) years. Studies of tissue electrical conductance were performed using the device "Electrodermatometer", measuring the indicators: modulus of complex impedance, impedance angle, complex impedance, and electrical capacity. Results and discussion. The study showed that in patients with BC and increased risk of RC, there was a decrease in the complex impedance of tissues at the study points during RT. The modulus of complex impedance at the mitral area decreased by only 6.8% (p > 0.05), while at the aortic, pulmonic and tricuspid areas, this figure was significantly (p < 0.05) decreased by 27.0%; 26.2% and 33.0%, respectively, relative to the initial indicators for RT. It was found that the most pronounced changes in the skin electrical conductance in patients with BC at risk of RC were observed at the projection points of the tricuspid and pulmonic areas, where these indicators were significantly (p < 0.05) increased by 41.1% and 34.2% relative to the baseline and equaled 9.8 ± 0.89 pF and 9.8 ± 0.88 pF, respectively. Conclusions. In patients with breast cancer at risk of RC, there was a statistically significant decrease (p < 0.05) in the value of the modulus of complex impedance by an average of 23.3% and a statistically significant increase (p < 0.05) in the tissue electrical conductance by an average of 29.8% relative to the baseline during radiation therapy.

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Determination of Oxygen Perfusion in the Area of Radiation-Induced Fibrosis of the Skin in Patients With Breast Cancer and Its Role in Pathogenesis of Late Radiation Injury

Агишев¹,

Топузов²,

Krasnozhon³

et al. 2018

Exp. Onc.

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Aim: Late radiation injury in the form of radiation-induced fibrosis (RIF) is one of the many complications of radiation therapy. The aim was to evaluate oxygen perfusion in the skin in the area of late radiation injury manifested as RIF in patients with breast cancer. Materials and Methods: Based on our first-hand experience in treating late radiation injures of soft tissues in patients with breast cancer, we measured oxygen perfusion of the skin (tсрО2) in the area of late radiation injury using a transcutaneous monitor (oximeter) TCM 400 (Radiometer, Denmark). Results: Partial oxygen pressure tcpO2 in the RIF area in patients with breast cancer didn’t show any significant decrease compared to healthy tissue. Mean value of partial oxygen pressure tcpO2 in the RIF area was 42.650 ± 9.178 mmHg, in the healthy tissue it was 45.180 ± 8.025 mmHg. Maximal difference in tcpO2 between the damaged and healthy tissue was 30 mmHg. Conclusions: Results of the study suggest that there’s no significant difference between oxygen perfusion (tcpO2) in the area of RIF and healthy tissue.

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Clinical and morphological characteristics of skin and subcutaneous fat damage after surgical treatment and radiation therapy in patients with breast cancer (literature review)

Cited by 6 publications

References 13 publications

Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer

Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer

Characteristics of Skin Electrical Conductance in Patients With Breast Cancer and High Risk of Radiation Therapy-Related Complications

Determination of Oxygen Perfusion in the Area of Radiation-Induced Fibrosis of the Skin in Patients With Breast Cancer and Its Role in Pathogenesis of Late Radiation Injury

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