Clinical and morphopathological assay in vulvovaginal candidiasis

Abstract

Candida vulvovaginitis is characterized by the appearance of inflammatory changes in the vaginal and vulvar epithelium secondary to infection with Candida species. The purpose of this study was to analyze and compare the clinical, microbiological, and histopathological aspects of pregnant and non-pregnant patients, symptomatic or asymptomatic in the case of candida vaginitis and to correlate the microscopic aspects with the symptoms before applying the local treatment with Nystatin. The study presents a retrospective analysis of the management of vaginitis in 166 pregnant or non-pregnant patients during 2021–2022. We observed the structure of the Malpighian squamous epithelium without keratinization present on the vaginal mucosa and the structure of the subepithelial connective tissue, which shows increased numerical values of inflammatory and vascular cellularity in the case of candida vaginitis symptomatic compared to asymptomatic ones. We noticed also in the microscopic study that in cases of asymptomatic patients before treatment, the number of inflammatory cells and blood vessels situated immediately under the epithelium was significantly lower compared to their number in symptomatic patients before treatment. Analyzing the results obtained after the administration of the treatment proposed by us, we can say that local Nystatin treatment is beneficial and safe for pregnant and non-pregnant patients and is a good alternative for patients with recurrent vulvovaginal candidiasis.

The Role of Probiotics in the Treatment of Vulvovaginal Candidiasis: A Systematic Review and Meta-Analysis

“…Vulvovaginal candidiasis (VVC) is one of the most common vaginal infections ( 1 , 2 ) affecting approximately 75% of women ( 2 , 3 ). VVC, with a range of symptoms and signs, has a negative impact on women's physical and emotional health as well as sexual and marital relationships ( 1 ).…”

Use of Povidone Iodine Vaginal Swabbing in Treatment of Recurrent Vulvovaginal Candidiasis

“…On examination, there is vulval erythema, edema, excoriation, and formation of fissures. In addition, introital and vaginal erythema are commonly present [5] . The VVC-associated vaginal discharge is usually white in color, and clumpy.…”