Clinical and neuroimaging correlates of progression of mild parkinsonian signs in community-dwelling older adults

Miller-Patterson, Cameron; Han, Jennifer; Yaffe, Kristine; Rosso, Andrea L.; Launer, Lenore J.; Kritchevsky, Stephen B.; Boudreau, Robert M.; Rosano, Caterina

doi:10.1016/j.parkreldis.2020.05.023

Cited by 8 publications

(14 citation statements)

References 29 publications

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“…Diabetes mellitus (DM) has also been associated with both the severity and progression of MPS 14,26,27,50,69,71 . In a subcategory analysis, DM was particularly related to the progression of gait and rigidity scores 26 .…”

Section: Resultsmentioning

confidence: 99%

“…16,19,70 Diabetes mellitus (DM) has also been associated with both the severity and progression of MPS. 14,26,27,50,69,71 In a subcategory analysis, DM was particularly related to the progression of gait and rigidity scores. 26 This relationship is not entirely clear, however, as adjusting for other vascular risk factors and peripheral neuropathy attenuated the association in one study.…”

Section: Vascular Risk Factorsmentioning

confidence: 96%

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Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations

et al. 2021

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A BS TRACT: Mild parkinsonian signs (MPS) have been widely studied during the past 3 decades and proposed as a risk marker for neurodegenerative disease. This systematic review explores the epidemiology, clinical and prognostic associations, radiological features, and pathological findings associated with MPS in older adults free from neurodegenerative disease. We find that MPS as currently defined are strongly associated with increasing age and increased risk of development of Parkinson's disease (PD), all-cause dementia, disability, and death. Positive associations with later PD are found mainly in younger populations and those with other features of prodromal PD. There are currently no consistent radiological findings for MPS, and pathological studies have shown that MPS, at least in the oldest old, are often underpinned by mixed neuropathologies, including those associated with Alzheimer's disease, cerebrovascular disease, nigral neuronal loss, and Lewy bodies. Different subcategories of MPS appear to convey varying risk and specificity for PD and other outcomes. MPS overall are not specific for parkinsonian disorders and, although associated with increased risk of PD, can reflect multiple pathologies, particularly in older individuals. "Mild motor signs" appears a more appropriate term to avoid prognostic and pathological implications, and larger future studies to prospectively examine outcomes and associations of specific MPS subcategories are required.

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Section: Resultsmentioning

confidence: 99%

Section: Vascular Risk Factorsmentioning

confidence: 96%

Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations

et al. 2021

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“…Sensitivity analyses are repeated excluding these six individuals. Subscores of bradykinesia and gait disturbance were also evaluated 9,10 …”

Section: Methodsmentioning

confidence: 99%

“…Although one of these studies suggested that periventricular connectivity was most affected in the frontal lobe, other studies did not provide information on the spatial distribution of connectivity abnormalities related with MPS 8 . Two neuroimaging studies of gray matter volumes found no associations between striatum and MPS, 9,10 perhaps because volumetric measures only capture more advanced changes compared to functional markers.…”

Section: Introductionmentioning

confidence: 99%

Cortico‐striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs

Hengenius

Bohnen

Rosso

et al. 2021

Journal of Neuroimaging

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Background and Purpose Mild Parkinsonian signs (MPS) are common in older adults. We hypothesized that MPS are associated with lower functional connectivity (FC) in dopamine‐dependent cortico‐striatal networks, and these associations vary with white matter hyperintensity (WMH), a risk factor for MPS. Methods We examined resting‐state functional MRI in 266 participants (mean age 83; 57% female; 41% African American) with data on MPS (Unified Parkinson's Disease Rating Scale), demographics, cognition, muscle‐skeletal, and cardiometabolic health. FC between cortex and striatum was examined separately for sensorimotor, executive, and limbic functional subregions. Logistic regression tested the association of FC in each network with MPS, adjusted for covariates. Interactions of FC by WMH were tested; and analyses were repeated stratified by WMH above/below the median. Results Compared to those without MPS, those with MPS had lower cortico‐striatal FC in the left executive network (adjusted odds ratio [95% confidence interval], p‐value: 0.188 [0.043, 0.824], .027). The interaction with WMH was p = .064; left executive FC was inversely associated with MPS for high WMH (0.077 [0.010, 0.599], .014) but not low WMH participants (1.245 [0.128, 12.132], .850). Conclusions MPS appear related to lower executive network FC, robust to adjustment for other risk factors, and stronger for those with higher burden of WMH. Future longitudinal studies should examine the interplay between cerebral small vessel disease and connectivity influencing MPS.

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“…After clinical treatment, the results showed that, after 3 weeks and 1 month of treatment, the VAS score, PRI score, PPI score, monthly pain days, and the number of cases Scientific Programming cured in the injection group were better than those in the ultrasound treatment group, and the differences were statistically significant (P < 0.05). e MRI results showed that, compared with participants in the healthy control group, patients with chronic pain caused by MTrP had decreased AK in the right parahippocampal gyrus, right medial prefrontal cortex, and right inferior frontal gyrus; patients with chronic pain caused by MTrP had decreased MK in the left [22]. Due to the long-term chronic pain, the gray matter microstructure of the patient's brain has actually changed, and the values of AK, MK, and RK are all decreased in contrast to those of the healthy population to varying degrees.…”

Section: Discussionmentioning

confidence: 94%

Convolutional Neural Network Optimization Algorithm-Based Magnetic Resonance Imaging in Analysis of Chronic Pain Caused by the Myofascial Trigger Point

Jin

Fan

Yao

2021

Scientific Programming

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This study was to explore the value of magnetic resonance imaging (MRI) technology processed by convolutional neural network (CNN) optimization algorithms in the clinical research of patients with chronic pain caused by myofascial trigger points (MTrPs). Firstly, referring to the traditional iterative algorithm, this study iterated the convolution network and data consistency layer as a whole for several times, which increased the fitting ability of the data consistency layer and network. When it was applied to magnetic resonance examination, it could be concluded that the effect of its reconstruction method was better than the traditional convolution neural network without the data consistency layer. The image edge was clear, and the restoration effect of details was better. 100 patients with chronic neck pain caused by MTrP were collected and divided into an ultrasound treatment group and a local anesthetic drug injection group, with 50 cases in each group. In addition, 50 healthy volunteers were selected. After clinical treatment, the results showed that, after 3 weeks of treatment, the visual analog score (VAS) and the pain rating index (PRI) of the injection group were 3.16 ± 1.14 points and 4.92 ± 1.26 points, respectively; the present pain intensity (PPI) score was 2.06 ± 0.85 points, and the number of pain days per month was 7.73 ± 1.15. After 1 month of treatment, the VSA and PRI of the injection group were 1.24 ± 0.89 and 1.31 ± 0.97, respectively; the PPI score was 1.34 ± 0.65, and the number of pain days per month was 5.34 ± 0.98. In addition, there were 38 cases reaching the level of clinical cure, accounting for 76%. Therefore, all indicators in the injection group were better than those in the ultrasound treatment group, and the differences were statistically significant ( P < 0.05 ). The results of MRI examination showed that compared with the healthy control group, patients with chronic pain caused by the myofascial trigger point had reduced axial kurtosis (AK), mean kurtosis (MK), and radial kurtosis (RK) in multiple brain areas such as the right parahippocampal gyrus and the right medial prefrontal cortex. In short, chronic pain caused by the trigger point of the myofascial membrane would affect the microstructure of the gray matter of the patient’s brain. In clinical treatment, the efficacy of local anesthetic injection was better than ultrasound therapy.

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Clinical and neuroimaging correlates of progression of mild parkinsonian signs in community-dwelling older adults

Cited by 8 publications

References 29 publications

Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations

Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations

Cortico‐striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs

Convolutional Neural Network Optimization Algorithm-Based Magnetic Resonance Imaging in Analysis of Chronic Pain Caused by the Myofascial Trigger Point

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