Clinical and Neuroimaging Features of Magnetic Resonance−Guided Stereotactic Laser Ablation for Newly Diagnosed and Recurrent Pediatric Brain Tumors: A Single Institutional Series

Pehlivan, Katherine C.; Khanna, Paritosh C.; Elster, Jennifer; Paul, Megan; Levy, Michael L.; Crawford, John R.; Gonda, David

doi:10.1016/j.wneu.2021.03.027

Cited by 5 publications

(9 citation statements)

References 13 publications

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“…In our series, we observed no mortality or long-term morbidity. Ahluwalia et al (13) stated that "no unanticipated adverse events occurred" in their adult series. The complications reported have primarily been bleeding, transient or permanent deficits related to proximity to eloquent areas, and edema, with no significant differences in adults and pediatric series (3,(6)(7)(8)(9)(10)(13)(14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Laser interstitial thermal therapy (LITT) for pediatric patients affected by intracranial tumors

et al. 2023

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IntroductionThe surgical treatment of brain tumors has evolved over time, offering different strategies tailored to patients and their specific lesions. Among these strategies, Laser Interstitial Thermal Therapy (LITT) is one of the most recent advances in pediatric neurooncological surgery, and its results and evolution are still under assessment.MethodsWe retrospectively analyzed data from six pediatric patients with deep-seated brain tumors treated with LITT at a single center between November 2019 and June 2022. A total of four patients underwent a stereotaxic biopsy during the same operating session. The indications and preparation for LITT, technical issues, clinical and radiological follow-up, impact on quality of life, and oncological treatment are discussed.ResultsThe mean patient age eight years (ranging from 2 to 11 years). The lesion was thalamic in four patients, thalamo-peduncular in one, and occipital posterior periventricular in one. In total, two patients had been previously diagnosed with low-grade glioma (LGG). Biopsies revealed LGG in two patients, ganglioglioma grade I in one, and diffuse high-grade glioma (HGG) in one. Postoperatively, two patients presented with transient motor deficits. The mean follow-up period was 17 months (ranging from 5 to 32 months). Radiological follow-up showed a progressive reduction of the tumor in patients with LGG.ConclusionLaser interstitial thermal therapy is a promising, minimally invasive treatment for deep-seated tumors in children. The results of lesion reduction appear to be relevant in LGGs and continue over time. It can be used as an alternative treatment for tumors located at sites that are difficult to access surgically or where other standard treatment options have failed.

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Section: Discussionmentioning

confidence: 99%

Laser interstitial thermal therapy (LITT) for pediatric patients affected by intracranial tumors

et al. 2023

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“…In the pediatric population, Pehlivan et al assessed the application of LITT as safe and efficient in 4 children with LGG whose seizure presentations either improved significantly or resolved entirely. Among other tumor entities included in the study, LITT yielded the most significant effects in LGG [ 25 ]. A case series of 8 children with LGG reported significant cytoreductive effects 15 to 36 months after LITT ablation [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…While progression-free survival (PFS) analyses for default treatment options such as surgical resection (5.5 to 6.2 years) [ 17 , 18 ], SRS (3.4 to 5.3 years) [ 19 , 20 , 21 , 22 ], and iMRT [ 23 ] have been studied largely, survival outcomes after LITT treatment in LGG remain limitedly available at this time [ 24 , 25 ]. Only one study presented by Leonardi et al evaluated survival outcomes after LITT in a larger-scale adult case series comprising 7 recurrent low-grade astrocytomas, reporting a mean overall survival (OS) of 144 months after diagnosis and 34 months after LITT, and a mean PFS of 16 months after LITT [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Only one study presented by Leonardi et al evaluated survival outcomes after LITT in a larger-scale adult case series comprising 7 recurrent low-grade astrocytomas, reporting a mean overall survival (OS) of 144 months after diagnosis and 34 months after LITT, and a mean PFS of 16 months after LITT [ 24 ]. In the pediatric population, Pehlivan et al assessed LITT as a safe and efficient treatment option in 4 children with LGG whose seizure expressions significantly improved [ 25 ]. In the same study, patients with LGG were found to have the most significant treatment response associated with LITT, yielding a mean tumor reduction of 90% and a complete response rate of 36% at a mean follow-up of 24 months [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the pediatric population, Pehlivan et al assessed LITT as a safe and efficient treatment option in 4 children with LGG whose seizure expressions significantly improved [ 25 ]. In the same study, patients with LGG were found to have the most significant treatment response associated with LITT, yielding a mean tumor reduction of 90% and a complete response rate of 36% at a mean follow-up of 24 months [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Management of Low-Grade Gliomas and Radiation Necrosis: A Single-Institution Case Series

et al. 2022

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Background: Laser interstitial thermal therapy (LITT) has emerged as a minimally invasive treatment modality for ablation of low-grade glioma (LGG) and radiation necrosis (RN). Objective: To evaluate the efficacy, safety, and survival outcomes of patients with radiographically presumed recurrent or newly diagnosed LGG and RN treated with LITT. Methods: The neuro-oncological database of a quaternary center was reviewed for all patients who underwent LITT for management of LGG between 1 January 2013 and 31 December 2020. Clinical data including demographics, lesion characteristics, and clinical and radiographic outcomes were collected. Kaplan–Meier analyses comprised overall survival (OS) and progression-free survival (PFS). Results: Nine patients (7 men, 2 women; mean [SD] age 50 [16] years) were included. Patients underwent LITT at a mean (SD) of 11.6 (8.5) years after diagnosis. Two (22%) patients had new lesions on radiographic imaging without prior treatment. In the other 7 patients, all (78%) had surgical resection, 6 (67%) had intensity-modulated radiation therapy and chemotherapy, respectively, and 4 (44%) had stereotactic radiosurgery. Two (22%) patients had lesions that were wild-type IDH1 status. Volumetric assessment of preoperative T1-weighted contrast-enhancing and T2-weighted fluid-attenuated inversion recovery (FLAIR) sequences yielded mean (SD) lesion volumes of 4.1 (6.5) cm3 and 26.7 (27.9) cm3, respectively. Three (33%) patients had evidence of radiographic progression after LITT. The pooled median (IQR) PFS for the cohort was 52 (56) months, median (IQR) OS after diagnosis was 183 (72) months, and median (IQR) OS after LITT was 52 (60) months. At the time of the study, 2 (22%) patients were deceased. Conclusions: LITT is a safe and effective treatment option for management of LGG and RN, however, there may be increased risk of permanent complications with treatment of deep-seated subcortical lesions.

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MR-guided laser interstitial thermal therapy in the treatment of brain tumors and epilepsy

Nielsen,

Rasmussen

2024

Acta Neurochir

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Clinical and Neuroimaging Features of Magnetic Resonance−Guided Stereotactic Laser Ablation for Newly Diagnosed and Recurrent Pediatric Brain Tumors: A Single Institutional Series

Cited by 5 publications

References 13 publications

Laser interstitial thermal therapy (LITT) for pediatric patients affected by intracranial tumors

Laser interstitial thermal therapy (LITT) for pediatric patients affected by intracranial tumors

Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Management of Low-Grade Gliomas and Radiation Necrosis: A Single-Institution Case Series

MR-guided laser interstitial thermal therapy in the treatment of brain tumors and epilepsy

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