Clinical and neuroimaging profile of congenital brain malformations in children with spastic cerebral palsy

Kułak, Wojciech; Sobaniec, Wojciech; Gościk, M; Oleński, J; Okurowska-Zawada, Bożena

doi:10.2478/v10039-008-0006-z

Cited by 18 publications

(7 citation statements)

References 34 publications

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“…In our study male preponderance over females was observed as 64.91% patients belonged to male sex against 35.08% females. Male preponderance has also been reported by Kulak W et al 26 whose study had 67.27% males. However, Yamada K et al 27 found female preponderance of 60.52% in their study of 38 cases of CP.…”

Section: Discussionsupporting

confidence: 71%

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Cerebral palsy: risk factors, comorbidities and associated MRI findings, a hospital based observational study

Najar

Kachroo

Gattoo

et al. 2015

Int J Contemp Pediatr

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Background: Cerebral palsy is a common pediatric disorder occurring in about 2-2.5/1000 live births. It is a chronic motor disorder resulting from a non-progressive static insult to the developing brain. There are various risk factors associated with it. Also it is accompanied with varied comorbidities and MRI findings depending on the etiology. Aims and objectives: To study the various risk factors, comorbidities and MRI findings in patients with cerebral palsy patients. Methods: A hospital based observational study was undertaken in the post graduate department of pediatrics, GB pant hospital, GMC Srinagar, Northern India. The study was carried out over a period of one year from September, 2009 to August 2010. During this year 22036 patients were admitted in this hospital, of which 2077 (9.42%) were neurological cases. Of these 2077 neurological cases, 145 (6.98%) were cerebral palsy patients, however only 57 children were included in our study. Other 88 CP cases were excluded as they were not fulfilling the inclusion criteria. After thorough clinical history and examination relevant investigations were done including MRI brain. Results: The commonest type of CP was spastic diplegia 28 (49.1%). Other types were spastic quadriplegia in 11 (19.29%), spastic hemiplegia 11 (19.29%), choreoathetoid 4 (7.01%) & mixed in 3 (5.29%). Seizures 27 (47.36%), aspiration pneumonia and bronchopneumonia 8 (14.03%) each were the commonest comorbidities associated. Most common risk factors for cerebral palsy in our study were prematurity and perinatal asphyxia in 7 (31.8%) each. Other risk factors in decreasing order of frequency were, pregnancy induced hypertension (PIH) in mothers 5 (29.41%), multiple gestations 5 (29.41%), neonatal meningitis 4 (18.18%), hypothyroidism in mothers 3 (17.64%), toxoplasmosis 2 (1.76%), rubella 2 (11.76%), maternal diabetes mellitus 2 (3.5%), neonatal hyperbilirubinemia 3 (13.6%) and neonatal seizure in 1 (1.75%). MRI was abnormal in 49 (85.96%) patients with PVL in 22 (38.59%), cortical atrophy in 7 (12.22%), post HIE changes in 4 (7.01%),followed by basal ganglion lesions, lissencephaly, porencephalic cyst , schizencephaly cortical dysplasia, dilated ventricles and infarctions. Conclusions: The commonest type of CP was spastic diplegia 28 (49.1%), followed by spastic quadriplegia, spastic hemiplegia, choreoathetoid and mixed. Most common risk factors for cerebral palsy in our study were prematurity and perinatal asphyxia, followed by Pregnancy Induced Hypertension (PIH) in mothers, multiple gestations, neonatal meningitis, hypothyroidism in mothers, toxoplasmosis, rubella, maternal diabetes mellitus, neonatal hyperbilirubinemia and neonatal seizure. Seizures, aspiration pneumonia and bronchopneumon were the commonest comorbidities associated. MRI was abnormal in 49 (85.96%) patients with PVL, cortical atrophy, post HIE changes being the most common changes followed by basal ganglion lesions, lissencephaly porencephalic cyst, schizencephaly, cortical dysplasia, dilated ventricles and infarctions.

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Section: Discussionsupporting

confidence: 71%

“…Significant PVL has been reported in 73.8% of spastic diplegia cases by Mei-Hou et al 35 Kulak et al 26 has also reported higher percentage of PVL in spastic diplegia like us. However, Kwong et al 28 has reported higher PVL in (66%) tetraplegic cases in contrast to our study.…”

Section: Discussionmentioning

confidence: 80%

Cerebral palsy: risk factors, comorbidities and associated MRI findings, a hospital based observational study

Najar

Kachroo

Gattoo

et al. 2015

Int J Contemp Pediatr

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“…У больных детским церебральным параличом чаще выявляют такие пороки развития головного мозга, как голопрозэнцефалия, лиссэнцефалия, шизэнцефалия, пахигирия и полимикрогирия [19,20]. При голопрозэнцефалии конечный мозг не разделен на полушария и имеет вид полусферы в результате нарушения смыкания медуллярной трубки.…”

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Infantile cerebral palsy as a result of prenatal brain dysontogenesis

Salkov

Khudoerkov

2019

Ross. vestn. perinatol. pediatr.

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Infantile cerebral palsy (cerebral palsy) is one of the most common diseases of the nervoussystem in children. The etiology of cerebral palsy may differ, but structural changes in the brain in children are similar, regardless of clinical form. The paper summarizes the results of the recent studies on structural changes in the brain due to cerebral palsy. The literature sources demonstrate that the term of etiological factors impact on the developing brain of the fetus determines the characteristics of brain damage and localization of the damage, as well as the nature of the response from the nervous system.

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“…Individuals with cerebral palsy (CP) often have motor impairment syndromes that occur as a result of a permanent, non-progressive lesion of the brain (Kułak et al, 2008).…”

Section: Nirs and Planning And Execution Of Motor Skill Stimulimentioning

confidence: 99%

“…In the field of cerebral palsy (CP) research, several advanced neuroimaging techniques have been used to investigate and explicate the etiological basis of CP. Structural neuroimaging techniques, such as MRI (Griffiths et al, 2010;Horridge et al, 2011;Kułak et al, 2007;Kułak et al, 2008;Sööt et al, 2008), DTI (Fariaa et al, 2011;Rha et al, 2011;Yoshida et al, 2011) and CT (Accardo et al, 2009), have been applied to explicate the probable cause of CP because of structural changes in the brain due to brain mal development and/or lesion. Functional neuroimaging techniques, such as fMRI (Burton et al, 2009;Schwilling et al, 2012;Sutcliffe et al, 2009;Wingert et al, 2010) and PET/SPECT (Batista et al, 2007;Lee et al, 2007;Wong et al, 2006), have been employed to elucidate the functional change in the brain associated with activation of brain pre-and post tasks performed by individuals with CP.…”

Section: Objective and Significancementioning

confidence: 99%

Funtional Near Infrared Spectroscopy Study of Language, Joint Attention and Motor Skills

Chaudhary¹

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Clinical and neuroimaging profile of congenital brain malformations in children with spastic cerebral palsy

Cited by 18 publications

References 34 publications

Cerebral palsy: risk factors, comorbidities and associated MRI findings, a hospital based observational study

Cerebral palsy: risk factors, comorbidities and associated MRI findings, a hospital based observational study

Infantile cerebral palsy as a result of prenatal brain dysontogenesis

Funtional Near Infrared Spectroscopy Study of Language, Joint Attention and Motor Skills

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