Clinical and Neuropsychological Profiles of Obsessive-Compulsive Schizophrenia

Hwang, Mei‐Yuh; Morgan, Joel E.; Losconzcy, Miklos F.

doi:10.1176/jnp.12.1.91

Cited by 132 publications

(79 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13 The DIGS is a validated clinical assessment tool designed for diagnosing psychotic spectrum disorders, mood disorders as well as anxiety disorders and includes assessment for the lifetime presence of OCD.…”

Section: Patient Assessmentmentioning

confidence: 99%

“…Hwang et al 13 found that schizophrenic patients with OCD have a worse clinical course than schizophrenic patients without OCD. Such co-morbidity is also associated with poor treatment response, higher levels of negative symptoms, and greater impairment in levels of functioning.…”

Section: Introductionmentioning

confidence: 99%

“…This group of patients has a less favourable employment record, lower age-appropriate functioning and more severe impairment of social behaviour. 3,13 Previous studies 14 have described a history of early deviant behaviour in subjects with schizophrenia. Early deviance has also been shown to affect the age of onset of schizophrenia 15 , with an earlier onset being associated with a more severe course of illness.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and clinical characteristics of obsessive-compulsive disorder and obsessive compulsive symptoms in Afrikaner schizophrenia and schizoaffective disorder patients

Seedat

Roos²,

Pretorius³

et al. 2008

Afr. J. Psych

View full text Add to dashboard Cite

Objective: There is evidence of variation in the prevalence of co-morbid obsessive-compulsive disorder in schizophrenia amongst ethnic groups. This study evaluated the lifetime prevalence and clinical characteristics of obsessive-compulsive disorder (OCD)/ obsessive-compulsive symptoms (OCS) in Afrikaner schizophrenic and schizoaffective disorder patients. Method: An ongoing genetic study of schizophrenia is currently being conducted on the Afrikaner founder population. In this cohort of 400 subjects from the original genetic study, we identified 53 subjects with schizophrenia or schizoaffective disorder and co-morbid OCD/OCS (study group). They were matched for gender and age of onset of illness with 59 subjects who do not have OCD/OCS (control group). The diagnostic instrument used in this cohort is the Diagnostic Interview for Genetic Studies (DIGS) version 2, which has been translated into Afrikaans. In addition to the DIGS, information for the relevant clinical characteristics reported in this study was also drawn from a detailed narrative chronological summary report and clinical files. A checklist was completed. Results: The prevalence of co-morbid OCD/OCS amongst 400 subjects with schizophrenia or schizoaffective disorder was 13.2% [n=53] of which 40 were male and 13 female patients. The prevalence of OCD was 10.7% and OCS was 2.5%. Contamination obsessions [n=17] were the most common type of obsession reported, followed by religious obsessions [n=8]. The most prevalent compulsions were repetitive rituals [n=32] followed by checking behaviour [n=22]. Onset of psychotic symptoms was found to be insidious in 86.8% of the study group compared to 24.6% of the control group (p<0.0001). Second-generation antipsychotic use was found to be statistically more prevalent in the study group (77.4%), compared to the control group (45.8%) (p=0.0008). 73% of the study group experienced depressive symptoms compared to 50.8% of the control group. Both groups were found to have a similar incidence of suicidal thoughts and suicide attempts. Substance abuse amongst the control group was significantly higher (35.9%) compared to the study group (19.2%) (p <0.05). Cannabis was most commonly abused in both groups, followed by alcohol. Conclusion: The prevalence rate of 13.2% of co-morbid OCD/OCS in Afrikaner schizophrenia and schizoaffective disorder patients differs from findings in other ethnic groups, suggesting the possible role of genetic and cultural factors in the prevalence of co-morbid OCD/OCS. Second-generation antipsychotic use amongst schizophrenia and schizoaffective disorder patients with co-morbid OCD/OCS was found to be significantly higher than in those without co-morbid OCD/OCS. Clinical characteristics of Afrikaner schizophrenics and schizoaffective disorder patients with and without co-morbid OCD/OCS are the same, both groups were associated with significant psychopathology and a poor prognosis. phenomena in schizophrenia at between 3-59.2%. 4 This is considerably higher than the rate of 2-3% of OCD...

show abstract

Section: Patient Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and clinical characteristics of obsessive-compulsive disorder and obsessive compulsive symptoms in Afrikaner schizophrenia and schizoaffective disorder patients

Seedat

Roos²,

Pretorius³

et al. 2008

Afr. J. Psych

View full text Add to dashboard Cite

show abstract

“…Furthermore, Mukhopadhaya et al (2009) reported that schizo-OCD cases treated with SSRIs showed greater levels of extra-pyramidal side effects compared with untreated counterparts. Finally, schizo-obsessives are greater health service users compared with subjects with schizophrenia (Berman et al 1995) and have a longer duration of hospitalizations (Fenton & McGlashan, 1986 ;Berman et al 1995 ;Hwang et al 2000). Clarification of the neuro-biological status of schizo-OCD may prompt modification of existing treatment strategies or even the development of new targeted treatments for this prominently disabled group.…”

Section: Introductionmentioning

confidence: 99%

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

et al. 2009

View full text Add to dashboard Cite

Background. Interest in the neuro-cognitive profile of patients with schizophrenia and co-morbid obsessive compulsive disorder (schizo-OCD) is rising in response to reports of high co-morbidity rates. Whereas schizophrenia has been associated with global impairment in a wide range of neuro-cognitive domains, OCD is associated with specific deficits featuring impaired performance on tasks of motor and cognitive inhibition involving frontostriatal neurocircuitry.Method. We compared cognitive function using the CANTAB battery in patients with schizo-OCD (n=12) and a schizophrenia group without OCD symptoms (n=16). The groups were matched for IQ, gender, age, medication, and duration of illness.Results. The schizo-OCD patients made significantly more errors on a task of attentional set-shifting (ID-ED set-shift task). By contrast, no significant differences emerged on the Stockings of Cambridge task, the Cambridge Gamble Task or the Affective Go/NoGo tasks. No correlation emerged between ID-ED performance and severity of schizophrenia, OCD or depressive symptoms, consistent with neurocognitive impairment holding trait rather than statemarker status. Schizo-obsessives also exhibited a trend toward more motor tics emphasizing a neurological contribution to the disorder. Conclusion.Our findings reveal a more severe attentional set-shifting deficit and neurological abnormality that may be fundamental to the neuro-cognitive profile of schizo-OCD. The clinical implications of these impairments merit further exploration in larger studies.

show abstract

“…One study found a correlation between higher levels of OCS and poorer delayed visual memory, as well as decreased cognitive flexibility as measured by the Wisconsin Card Sorting Test (WCST) and Trail Making test. 8 Others have also observed an association between OCS and poorer executive functioning as measured by the WCST 9,10 , though failures to find a relationship with either the WCST or other tests of executive function have also been reported. 11–13 …”

mentioning

confidence: 99%

Nonclinical Obsessive-Compulsive Symptoms and Executive Functions in Schizophrenia

Kumbhani¹,

Roth²,

Kruck³

et al. 2010

Journal of Neuropsychiatry

View full text Add to dashboard Cite

The impact of non-clinical obsessive compulsive symptoms (OCS) on neuropsychological functioning in schizophrenia has received little investigation. We evaluated whether severity and subtype of OCS are associated with executive functioning in schizophrenia. Twenty-nine patients with schizophrenia and 32 healthy subjects completed questionnaire and performance-based measures of executive functioning Overall OCS severity in patients was associated with poorer monitoring and cognitive flexibility per a questionnaire. Obsessing, hoarding, and checking were related to poorer executive functioning in daily life. Performance-based scores showed few correlations with OCS. Findings indicate that severity of non-clinical OCS subtypes contribute to the heterogeneity of executive functions in schizophrenia.

show abstract

Clinical and Neuropsychological Profiles of Obsessive-Compulsive Schizophrenia

Cited by 132 publications

References 22 publications

Prevalence and clinical characteristics of obsessive-compulsive disorder and obsessive compulsive symptoms in Afrikaner schizophrenia and schizoaffective disorder patients

Prevalence and clinical characteristics of obsessive-compulsive disorder and obsessive compulsive symptoms in Afrikaner schizophrenia and schizoaffective disorder patients

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

Nonclinical Obsessive-Compulsive Symptoms and Executive Functions in Schizophrenia

Contact Info

Product

Resources

About