Clinical and Objective Data of Spinal Cord Stimulation for the Treatment of Severe Raynaud's Phenomenon

Neuhauser, Beate; Perkmann, Reinhold; Klinger, P.J.; Giacomuzzi, Salvatore; Kofler, Alexandra; Fraedrich, G.

doi:10.1053/ejvx.2000.0002

Cited by 10 publications

(12 citation statements)

References 5 publications

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“…In 2001 Neuhauser et al reported on a patient with severe primary Raynaud's phenomenon who had significant pain relief and complete healing of ischemic digital ulcerations after SCS. Microcirculatory parameters were assessed before and after stimulation with capillary microscopy and laser Doppler anemometry: These documented significant improvements in red blood cell velocity, capillary density, and capillary permeability (15). Similar results were seen in two other case reports (16,17).…”

Section: Discussionsupporting

confidence: 71%

Spinal Cord Stimulation for Raynaud’s Syndrome: Long-Term Alleviation of Bilateral Pain With a Single Cervical Lead

Wolter

Kieselbach

2011

Neuromodulation: Technology at the Neural Interface

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Section: Discussionsupporting

confidence: 71%

Spinal Cord Stimulation for Raynaud’s Syndrome: Long-Term Alleviation of Bilateral Pain With a Single Cervical Lead

Wolter

Kieselbach

2011

Neuromodulation: Technology at the Neural Interface

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“…Current evidence for the use of SCS for Raynaud's phenomenon is based chiefly on case reports, which suggest that SCS could be a promising treatment (Table ). Raso followed 1048 Raynaud patients for ten years, including 40 with critical ischemia who were treated with SCS.…”

Section: Mixed Neuropathic–vascular Conditionsmentioning

confidence: 99%

The Appropriate Use of Neurostimulation of the Spinal Cord and Peripheral Nervous System for the Treatment of Chronic Pain and Ischemic Diseases: The Neuromodulation Appropriateness Consensus Committee

Deer¹,

Mekhail

Provenzano³

et al. 2014

Neuromodulation: Technology at the Neural Interface

504

349

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“…The effectiveness of SCS depends on the segments being stimulated and synaptic interaction. SCS at the lower cervical spinal segments such as C5-C6 is used to treat ischemic diseases, such as Raynaud's disease in the upper limbs (Robaina et al, 1989;Sciacca et al, 1998;Neuhauser et al, 2001). However, in patients with lower limb diseases, SCS at the upper lumbar spinal segments such as L2-L3 produced the largest increase in cutaneous blood flow in the lower limbs.…”

Section: 12mentioning

confidence: 99%

Putative mechanisms behind effects of spinal cord stimulation on vascular diseases: A review of experimental studies

Linderoth

Foreman

2008

Autonomic Neuroscience

159

106

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Spinal cord stimulation (SCS) is a widely used clinical technique to treat ischemic pain in peripheral, cardiac and cerebral vascular diseases. The use of this treatment advanced rapidly during the late 80's and 90's, particularly in Europe. Although the clinical benefits of SCS are clear and the success rate remains high, the mechanisms are not yet completely understood. SCS at lumbar spinal segments (L2-L3) produces vasodilation in the lower limbs and feet which is mediated by antidromic activation of sensory fibers and decreased sympathetic outflow. SCS at thoracic spinal segments (T1-T2) induces several benefits including pain relief, reduction in both frequency and severity of angina attacks, and reduced short-acting nitrate intake. The benefits to the heart are not likely due to an increase, or redistribution of local blood flow, rather, they are associated with SCS-induced myocardial protection and normalization of the intrinsic cardiac nervous system. At somewhat lower cervical levels (C3-C6), SCS induces increased blood flow in the upper extremities. SCS at the upper cervical spinal segments (C1-C2) increased cerebral blood flow, which is associated with a decrease in sympathetic activity, an increase in vasomotor center activity and a release of neurohumoral factors. This review will summarize the basic science studies that have contributed to our understanding about mechanisms through which SCS produces beneficial effects when used in the treatment of vascular diseases. Furthermore, this review will particularly focus on the antidromic mechanisms of SCS-induced vasodilation in the lower limbs and feet.

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Clinical and Objective Data of Spinal Cord Stimulation for the Treatment of Severe Raynaud's Phenomenon

Cited by 10 publications

References 5 publications

Spinal Cord Stimulation for Raynaud’s Syndrome: Long-Term Alleviation of Bilateral Pain With a Single Cervical Lead

Spinal Cord Stimulation for Raynaud’s Syndrome: Long-Term Alleviation of Bilateral Pain With a Single Cervical Lead

The Appropriate Use of Neurostimulation of the Spinal Cord and Peripheral Nervous System for the Treatment of Chronic Pain and Ischemic Diseases: The Neuromodulation Appropriateness Consensus Committee

Putative mechanisms behind effects of spinal cord stimulation on vascular diseases: A review of experimental studies

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