Clinical and Pathogenetic Studies of Medical Lake Macaque Virus Infections in Cynomolgus Monkeys (Simian Varicella)

Wenner, Herbert A.; Abel, David; Barrick, Shloe; Seshumurty, P.

doi:10.1093/infdis/135.4.611

Cited by 31 publications

(24 citation statements)

References 6 publications

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“…5). 136 The underlying dermis is edematous and contains areas of necrosis and infiltrates of mononuclear inflammatory cells, some of which contain intranuclear inclusions. 14 Grossly, the lung contains multifocal to coalescent foci of hemorrhage and edema.…”

Section: Simian Varicella Virusmentioning

confidence: 99%

REVIEW PAPER: Emerging and Reemerging Infectious Diseases of Nonhuman Primates in the Laboratory Setting

Bailey

Mansfield

2010

Vet Pathol

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Despite numerous advances in the diagnosis and control of infectious diseases of nonhuman primates in the laboratory setting, a number of infectious agents continue to plague colonies. Some, such as measles virus and Mycobacterium tuberculosis, cause sporadic outbreaks despite well-established biosecurity protocols, whereas others, such as retroperitoneal fibromatosis-associated herpesvirus, have only recently been discovered, often as a result of immunosuppressive experimental manipulation. Owing to the unique social housing requirements of nonhuman primates, importation of foreign-bred animals, and lack of antemortem diagnostic assays for many new diseases, elimination of these agents is often difficult or impractical. Recognition of these diseases is therefore essential because of their confounding effects on experimental data, impact on colony health, and potential for zoonotic transmission. This review summarizes the relevant pathology and pathogenesis of emerging and reemerging infectious diseases of laboratory nonhuman primates.

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Section: Simian Varicella Virusmentioning

confidence: 99%

REVIEW PAPER: Emerging and Reemerging Infectious Diseases of Nonhuman Primates in the Laboratory Setting

Bailey

Mansfield

2010

Vet Pathol

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“…Although the true host for natural SVV infection is unknown, epidemic outbreaks in different species of monkeys including African green, patas and macaques were reported in the 1960s at different primate centers in both the US and UK [142]. Clinical, pathological, immunological and virological features of SVV infection of nonhuman primates closely resemble those of human VZV infection [143,144]. After an incubation period of one or more weeks, SVV leads to fever and a papulovesicular rash of skin and mucous membranes in monkeys.…”

Section: Development Of Animal Modelsmentioning

confidence: 99%

Clinical and Molecular Aspects of Varicella Zoster Virus Infection

et al. 2008

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SummaryA declining cell-mediated immunity to varicella zoster virus (VZV) with advancing age or immunosuppression results in virus reactivation from latently infected human ganglia anywhere along the neuraxis. Virus reactivation produces zoster, often followed by chronic pain (postherpetic neuralgia or PHN) as well as vasculopathy, myelopathy, retinal necrosis and cerebellitis. VZV reactivation also produces pain without rash (zoster sine herpete). Vaccination after age 60 reduces the incidence of shingles by 51%, PHN by 66% and the burden of illness by 61%. However, even if every healthy adult over age 60 years is vaccinated, there would still be about 500,000 zoster cases annually in the United States alone, about 200,000 of whom will experience PHN. Analyses of viral nucleic acid and gene expression in latently infected human ganglia and in an animal model of varicella latency in primates are serving to determine the mechanism(s) of VZV reactivation with the aim of preventing reactivation and the clinical sequelae.

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“…Attempts to produce the disease by experimental infection of animals with VZV have led to seroconversion but not to disease (14). However, clinical, pathological, immunological, and virological evidence suggests that simian varicella virus (SVV) infection of nonhuman primates is the counterpart of human VZV infection (10,12).…”

Section: Primary Varicella-zoster Virus (Vzv) Infection Causes Chickementioning

confidence: 99%

Naturally Acquired Simian Varicella Virus Infection in African Green Monkeys

Mahalingam¹,

Traina‐Dorge

Wellish³

et al. 2002

J Virol

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Simian varicella virus (SVV) infection. The four naturally exposed monkeys developed mild varicella 10 to 14 days later, and skin scrapings taken at the time of the rash contained SVV DNA. Analysis of multiple ganglia, liver, and lung tissues from the four naturally exposed monkeys sacrificed 6 to 8 weeks after resolution of the rash revealed SVV DNA in ganglia at multiple levels of the neuraxis but not in the lung or liver tissue of any of the four monkeys. This animal model provides an experimental system to gain information about varicella latency with direct relevance to the human disease.

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Clinical and Pathogenetic Studies of Medical Lake Macaque Virus Infections in Cynomolgus Monkeys (Simian Varicella)

Cited by 31 publications

References 6 publications

REVIEW PAPER: Emerging and Reemerging Infectious Diseases of Nonhuman Primates in the Laboratory Setting

REVIEW PAPER: Emerging and Reemerging Infectious Diseases of Nonhuman Primates in the Laboratory Setting

Clinical and Molecular Aspects of Varicella Zoster Virus Infection

Naturally Acquired Simian Varicella Virus Infection in African Green Monkeys

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