Clinical and Pathologic Factors of Prognostic Significance in Penile Squamous Cell Carcinoma in a North American Population

Bethune, Gillian C.; Campbell, J. A.; Rocker, Adam; Bell, David; Rendon, Ricardo; Merrimen, Jennifer

doi:10.1016/j.urology.2011.12.048

Cited by 45 publications

(23 citation statements)

References 30 publications

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“…Age and smoking were not significantly associated with survival in the present study, comparable with other reports [3,10,11]. However, there is controversy involving age, showing that older age at time of diagnosis is associated with poor outcomes.…”

Section: Discussionsupporting

confidence: 86%

Prognostic factors in Taiwanese patients with penile‐invasive squamous cell carcinoma

Geng

Huang

2015

The Kaohsiung J of Med Scie

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In Taiwanese patients, carcinoma of the penis is an uncommon disease. We retrospectively reviewed potential prognostic factors in Taiwanese patients with invasive-penile squamous cell carcinoma (SCC). From 1997 to 2009, 52 patients were enrolled. The median patient age at diagnosis was 66.5 years and the peak incident occurred during the 6(th) and 7(th) decades of life. Thirteen patients (25%) died of penile cancer, with a mean follow-up time of 45 months (interquartile range: 15-64 months). The 5-year cumulative cancer-specific survival rate was 81%, with 100% for those with Stage I, 90% for those with Stage II, 60% for those with Stage III, and 14% for those with Stage IV. Eleven variables, including grade, tumor, node, metastasis (TNM) stage, involvement of corpus spongiosum or corpora cavernosa, lymphovascular or perineural invasion, lymphadenectomy, and palpable lymph node, with p < 0.05 using univariate analysis were chosen for multivariate regression analysis. Three of these potential prognostic factors, including histological grade, distant metastasis, and lymphovascular invasion, remained statistically significant. Our study is the first report using the latest TNM classification (2009) to determine these potential predictors with penile SCC in Taiwan.

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Section: Discussionsupporting

confidence: 86%

Prognostic factors in Taiwanese patients with penile‐invasive squamous cell carcinoma

Geng

Huang

2015

The Kaohsiung J of Med Scie

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“…Moving forward, investigations into the role of HPV in penile SCC and any effects on prevention, prognosis, and treatment will be of great interest. 25 In the present study, 10 patients presented with clinically palpable nodal disease -the strongest predictor of poor prognosis. 26 Of these, 3 had such extensive disease that they were deemed inoperable and treated with palliative intent only.…”

Section: Discussionmentioning

confidence: 52%

Penile cancer: Perspective from a Canadian tertiary care centre

Beech¹,

Izawa²,

Pautler³

et al. 2015

CUAJ

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Introduction: Penile squamous cell carcinoma (SCC) is rare in North America; however, the morbidity can be devastating. This analysis represents the first reported penile cancer experience at a tertiary care centre in Canada. Methods: We carried out a retrospective review of all patients who received care at our centre for penile SCC from 2005 until the present time. Epidemiological and clinical data were collected for all patients. Survival analysis was performed using Kaplan-Meier methods with log-rank test and Cox regression for univariate and multivariate analysis, respectively. Results: We identified 42 patients who were treated at our centre for penile SCC. Of these, 29% underwent excisional biopsy, 38% had partial penectomy, and 33% had total penectomy. Five patients with high-risk tumours underwent modified inguinal lymph node dissection (ILND), while 7 patients had radical ILND for clinically palpable disease. Overall, the median cancer specific survival (CSS) was undefined, with a 60% survival at 102 months. However CSS was significantly correlated to pT stage, pN stage, and tumour grade. The median follow-up was 25 months (interquartile range: 11-48). Conclusion: These findings confirm the poor CSS of patients with positive lymph nodes in penile SCC. Patients with pN0 after ILND had a durable CSS. Risk factors for penile SCC were confirmed as elevated body mass index, positive smoking history, and lack of circumcision. This first epidemiologic report on penile SCC from a Canadian tertiary care centre should be expanded to other national centres.

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“…Disease-specific survival. Among the eight studies reporting DSS according to p16 status (20,21,31,33,(38)(39)(40)43), it was possible to include seven studies (20,21,31,33,38,40,43) in the pooled meta-analysis. Figure 3 shows the study-specific and pooled HR of DSS according to p16 status.…”

Section: Survival According To P16 Statusmentioning

confidence: 99%

“…Overall survival. Three studies (29,38,43) were included in a meta-analysis on OS in relation to p16 status. A total of 116 men with penile cancer were included of which 61 and 55 were p16-positive and -negative, respectively.…”

Section: Survival According To P16 Statusmentioning

confidence: 99%

Prognostic Significance of HPV and p16 Status in Men Diagnosed with Penile Cancer: A Systematic Review and Meta-analysis

Sand

Rasmussen

Frederiksen

et al. 2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

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It has been shown that human papillomavirus (HPV) and p16 status has prognostic value in some HPV-associated cancers. However, studies examining survival in men with penile cancer according to HPV or p16 status are often inconclusive, mainly because of small study populations. The aim of this systematic review and meta-analysis was to examine the association between HPV DNA and p16 status and survival in men diagnosed with penile cancer. Multiple electronic databases were searched. Twenty studies were ultimately included and study-specific and pooled HRs of overall survival and disease-specific survival (DSS) were calculated using a fixed effects model. In the analysis of DSS, we included 649 men with penile cancer tested for HPV (27% were HPV-positive) and 404 men tested for p16 expression (47% were p16-positive). The pooled HR of DSS was 0.61 [95% confidence interval (CI), 0.38-0.98], and the pooled HR of DSS was 0.45 (95% CI, 0.30-0.69). In conclusion, men with HPV or p16-positive penile cancer have a significantly more favorable DSS compared with men with HPV or p16-negative penile cancer. These findings point to the possible clinical value of HPV and p16 testing when planning the most optimal management and follow-up strategy. .

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Clinical and Pathologic Factors of Prognostic Significance in Penile Squamous Cell Carcinoma in a North American Population

Cited by 45 publications

References 30 publications

Prognostic factors in Taiwanese patients with penile‐invasive squamous cell carcinoma

Prognostic factors in Taiwanese patients with penile‐invasive squamous cell carcinoma

Penile cancer: Perspective from a Canadian tertiary care centre

Prognostic Significance of HPV and p16 Status in Men Diagnosed with Penile Cancer: A Systematic Review and Meta-analysis

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