Clinical and pathological characteristics of early-onset colorectal cancer in South Korea

Park, Su Bee; Yoon, Jin Young; Kwak, Min Seob; Myung, Jae

doi:10.4103/sjg.sjg_35_23

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…survival time and quality of life of patients with advanced metastatic disease have been improved [27] .However, it has been shown that while improving the prognosis of patients with CRC, chemotherapeutic agents also increase the rate of associated complications [26,15] . Chemotherapy primarily induces excessive immune activation and can even directly harm non-target organs, especially the heart, with cardiovascular causes being the most common non-tumor death reasons in colorectal cancer [44] .…”

Section: Discussionmentioning

confidence: 99%

Nomogram model for predicting cause-specific mortality in patients with Early-Onset Colorectal Cancer: a competing risk analysis Insight from the SEER Database and a Chinese Cohort.

Fu,

Chen,

Fan

et al. 2023

Preprint

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Objective This study aims to analyze the risk factors for Cancer-Specific Mortality (CSM) and Other-Cause Mortality (OCM) in early-onset colorectal cancer (EOCRC) patients,and to construct a nomogram for predicting CSM based on a competitive risk model and validate it using training, internal, and external cohorts. Methods EOCRC patients from the SEER database(2008–2017). Furthermore, EOCRC patients treated at a Northeast China tertiary hospital were included(2014–2020). The SEER data were randomly divided into training and validation sets at a 7:3 ratio. Univariate COX regression model was used to screen for prognostic correlates. Multivariate Cox regression models were then employed to identify independent risk factors. A nomogram visualized results, assessed by C-index,AUC and calibration curves. DCA evaluated clinical utility. Results A total of 8,813 patients were collected from the SEER database, divided into training (N = 6,610) and validation (N = 2,203) sets. 76 patients were included from the Chinese cohort(N = 76). Multivariable Cox regression models revealed that race, tumor differentiation, carcinoembryonic antigen (CEA), marital status, histological type, AJCC stage, and surgical status were independent risk factors for CSM in EOCRC patients. The nomogram constructed based on those independent risk factors had good performance with C-index of 0.806 ,0.801and 0.810 for the training, internal validation and external validation cohorts, respectively.Calibration curves and AUC also indicated the nomogram's accuracy and discriminative ability. Also DCA reflects the good clinical value of the model. Conclusion This study successfully established a competing risk model for CSM in EOCRC patients, demonstrating good predictive value, which may help clinicians to make better treatment decision making.

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Section: Discussionmentioning

confidence: 99%

Nomogram model for predicting cause-specific mortality in patients with Early-Onset Colorectal Cancer: a competing risk analysis Insight from the SEER Database and a Chinese Cohort.

Fu,

Chen,

Fan

et al. 2023

Preprint

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Five-year overall survival of early- and late-onset colorectal cancer in Medellín, Colombia: a comparative study

Ruiz-Grajales,

Correa-Cote,

Sánchez-Zapata

et al. 2024

J Cancer Res Clin Oncol

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Purpose Early-onset colorectal cancer (CRC) (EOCRC, < 50 years) has distinct clinicopathological features from late-onset CRC (LOCRC, ≥ 50 years). However, evidence on survival outcomes is contradictory. We aimed to analyse the differences in 5-year overall survival (OS) between EOCRC and LOCRC. Methods A retrospective cohort study was conducted during 2018–2022. Individuals aged ≥ 18 years diagnosed with CRC at two hospitals in Medellín, Colombia were included. Clinicopathological and survival data were retrieved from the medical records and a public government database. Patients were categorized into EOCRC and LOCRC groups. Five-year OS rates were calculated using the Kaplan-Meier method and prognostic factors for OS were identified through Cox regression models. Results Among 1022 patients, 52.5% were female, and 13.5% (n = 138) had EOCRC. Patients with EOCRC showed higher 5-year OS rates than LOCRC patients (54% vs. 32%). Univariable analyses indicated a 37% lower risk of death for EOCRC compared to LOCRC (HR: 0.633, 95%CI: 0.476–0.840, p = 0.002). After multivariable analyses, advanced staging and higher tumour grading were prognostic factors for worse OS (HR: 2.127, 95% CI:1.405–3.220, p = 0.0001; and HR: 12.896, 95%CI: 6.310-26.355, p = 0.000; respectively), and being in the EOCRC group remained as a prognostic factor for higher OS (HR: 0.482, 95% CI: 0.336–0.690, p = 0.000). Conclusion EOCRC is associated with significantly better 5-year OS rates and prognosis compared to LOCRC. Advanced stage and higher tumour grading are predictors of lower OS among all CRC patients. These findings highlight the importance of age-related risk stratification and personalized therapeutic approaches in CRC.

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Five-Year Overall Survival of Early- and Late-Onset Colorectal Cancer in Medellín, Colombia: A Comparative Study

Ruiz-Grajales,

Correa-Cote,

Sánchez-Zapata

et al. 2024

Preprint

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Purpose Early-onset colorectal cancer (CRC) (EOCRC, < 50 years) has distinct clinicopathological features from late-onset CRC (LOCRC, ≥ 50 years). However, evidence on survival outcomes is contradictory. We aimed to analyse the differences in 5-year overall survival (OS) between EOCRC and LOCRC. Methods A retrospective cohort study was conducted during 2018–2022. Individuals aged ≥ 18 years diagnosed with CRC at two hospitals in Medellín, Colombia were included. Clinicopathological and survival data were retrieved from the medical records and a public government database. Patients were categorized into EOCRC and LOCRC groups. Five-year OS rates were calculated using the Kaplan-Meier method and prognostic factors for OS were identified through Cox regression models. Results Among 1022 patients, 52.5% were female, and 13.5% (n = 138) had EOCRC. EOCRC patients had higher 5-year OS rates than LOCRC patients (54% vs. 32%, Log-Rank, p = 0.001). Univariable analyses indicated a 37% lower risk of death for EOCRC compared to LOCRC (HR: 0.633, 95% CI: 0.476–0.840). After multivariable analyses, advanced staging and higher tumour grading were prognostic factors for worse OS (HR: 2.127, 95% CI: 1.405–3.220 and HR: 12.896, 95% CI: 6.310-26.355, respectively). Conversely, being in the EOCRC group remained as a prognostic factor for higher OS (HR: 0.482, 95% CI: 0.336–0.690). Conclusion EOCRC is associated with significantly better 5-year OS rates and prognosis compared to LOCRC. Advanced stage and higher tumour grading are predictors of lower OS among all CRC patients. These findings highlight the importance of age-related risk stratification and personalized therapeutic approaches in CRC.

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Clinical and pathological characteristics of early-onset colorectal cancer in South Korea

Cited by 3 publications

References 34 publications

Nomogram model for predicting cause-specific mortality in patients with Early-Onset Colorectal Cancer: a competing risk analysis Insight from the SEER Database and a Chinese Cohort.

Nomogram model for predicting cause-specific mortality in patients with Early-Onset Colorectal Cancer: a competing risk analysis Insight from the SEER Database and a Chinese Cohort.

Five-year overall survival of early- and late-onset colorectal cancer in Medellín, Colombia: a comparative study

Five-Year Overall Survival of Early- and Late-Onset Colorectal Cancer in Medellín, Colombia: A Comparative Study

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