Clinical and pathological characteristics of 2019 novel coronavirus disease (COVID-19): a systematic reviews

Mao, Yaqian; Lin, Wei; Wen, Junping; Chen, Gang

doi:10.1101/2020.02.20.20025601

Cited by 29 publications

(34 citation statements)

References 47 publications

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“…When an individual makes contact with a surface, there is an exchange of microbial life (35), including a transfer of viruses from the individual to the surface and vice versa (36). Once infected, individuals with COVID-19 shed viral particles before, during, and after developing symptoms (37,38). These viral particles can then settle onto abiotic objects in the BE and potentially serve as reservoirs for viral transmission (18,34,39).…”

mentioning

confidence: 99%

“…Items should be removed from sink areas to ensure aerosolized water droplets do not carry viral particles onto commonly used items, and countertops around sinks should be cleaned using a 10% bleach solution or an alcohol-based cleaner on a regular basis. Again, it is important to remember that the main and much more common spread mechanism of previous CoVs has been identified as droplets from talking, sneezing, coughing, and vomiting than by the fecal-oral pathway (34,38,39). Administrators and building operators should post signage about the effectiveness of handwashing for at least 20 s with soap and hot water, ensure soap dispensers are full, provide access to alcohol-based hand sanitizer, and implement routine surface cleaning protocols to high-touch surfaces where contamination risks are high, such as around sinks and toilets (39).…”

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confidence: 99%

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2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission

et al. 2020

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With the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in coronavirus disease 2019 (COVID-19), corporate entities, federal, state, county, and city governments, universities, school districts, places of worship, prisons, health care facilities, assisted living organizations, daycares, homeowners, and other building owners and occupants have an opportunity to reduce the potential for transmission through built environment (BE)-mediated pathways. Over the last decade, substantial research into the presence, abundance, diversity, function, and transmission of microbes in the BE has taken place and revealed common pathogen exchange pathways and mechanisms. In this paper, we synthesize this microbiology of the BE research and the known information about SARS-CoV-2 to provide actionable and achievable guidance to BE decision makers, building operators, and all indoor occupants attempting to minimize infectious disease transmission through environmentally mediated pathways. We believe this information is useful to corporate and public administrators and individuals responsible for building operations and environmental services in their decision-making process about the degree and duration of social-distancing measures during viral epidemics and pandemics.

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2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission

et al. 2020

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“…Finally, a non-reviewed study by Yaqian et al (8) uncovered this fact: "people mixed up COVID-19 with its big brother SARS". While diarrhea was found in 30% of patients with SARS, researchers found diarrhea in only 5% of patients with COVID-19.…”

Section: Resultsmentioning

confidence: 99%

Panic of Buying Toilet Papers: A Historical Memory or a Horrible Truth? Systematic Review of Gastrointestinal Manifestations of COVID-19

Miri¹,

Roozbeh

Omranirad

et al. 2020

Hepat Mon

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Context: Within only 30 days after the first announcement of infection with "SARS-CoV-2" in Wuhan, it spread to more than 20 countries and become a pandemic by WHO as a "high alarming level of infection" with 136,343 involved cases all over the world. Methods: To uncover more about the probable gastrointestinal transmission and its clinical manifestations, we reviewed all research publications with keywords including: "COVID-19", "SARS-CoV-2", "Coronavirus", "outbreak", "ARAS-CoV" in Medline, Scopus, Google Scholar as well as all news in social media about "novel COVID-19 pandemic". Out of 40 recent publications, 10 articles were studied by 2 authors. Results: Although the SARS-CoV-2 tends to infect respiratory epithelial cells through the respiratory tracts, recent investigations detected the virus in the stool specimen, raising the question of the fecal-oral transmission route. Different studies showed that almost all gastrointestinal signs and symptoms were seen in elderly patients (more than 65 years old). including anorexia (40%), nonspecific abdominal pains (8%), diarrhea (10%) and nausea and Vomiting in about 8% of patients. Anorexia and generalized abdominal pain suffer many treated cases even 10-20 days after negative blood tests (like CRP, lymphopenia) and negative PCR of respiratory samples. The main reason for this prolonged anorexia and abdominal pain may be due to the long persistence of COVID-19 in the gastrointestinal tracts after primary treatment. Conclusions: Comparing to SARS, patients with COVID-19 showed less diarrhea, nausea, vomiting and/or abdominal discomfort before respiratory symptoms. Feces as a potential contagious source of Viral RNA can last even after viral clearance in the respiratory tract. We strongly recommend all cured patients of COVID-19 to disinfect and clean their toilets until 17-20 days after negative blood tests and solving their respiratory disorders. Gastrointestinal manifestations have seen in all men while no women referred with GI signs.

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“…The cause of an outbreak of an unidentified respiratory disease, first detected in Wuhan, China, has been identified as a type of novel sub-coronavirus, initially named 2019-novel coronavirus (2019-nCoV) [1]. The World Health Organization (WHO) has officially named the virus "severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)", and the associated disease "coronavirus disease 2019 (COVID-19)" [2]. Since February 2020, COVID-19 cases of infection have rapidly expanded at a global level, and as of March 2020, more than 118,000 cases have been reported across 114 countries.…”

Section: Introductionmentioning

confidence: 99%

Correlations of Clinical and Laboratory Characteristics of COVID-19: A Systematic Review and Meta-Analysis

Ghayda

Lee

et al. 2020

IJERPH

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(1) Background: The global threat of Coronavirus disease 2019 (COVID-19) continues. The diversity of clinical characteristics and progress are reported in many countries as the duration of the pandemic is prolonged. We aimed to perform a novel systematic review and meta-analysis focusing on findings about correlations between clinical characteristics and laboratory features of patients with COVID-19. (2) Methods: We analyzed cases of COVID-19 in different countries by searching PubMed, Embase, Web of Science databases and Google Scholar, from the early stage of the outbreak to late March. Clinical characteristics, laboratory findings, and treatment strategies were retrospectively reviewed for the analysis. (3) Results: Thirty-seven (n = 5196 participants) COVID-19-related studies were eligible for this systematic review and meta-analysis. Fever, cough and fatigue/myalgia were the most common symptoms of COVID-19, followed by some gastrointestinal symptoms which are also reported frequently. Laboratory markers of inflammation and infection including C-reactive protein (CRP) (65% (95% confidence interval (CI) 56–81%)) were elevated, while lymphocyte counts were decreased (63% (95% CI 47–78%)). Meta-analysis of treatment approaches indicated that three modalities of treatment were predominantly used in the majority of patients with a similar prevalence, including antiviral agents (79%), antibiotics (78%), and oxygen therapy (77%). Age was negatively correlated with number of lymphocytes, but positively correlated with dyspnea, number of white blood cells, neutrophils, and D-dimer. Chills had been proved to be positively correlated with chest tightness, lung abnormalities on computed tomography (CT) scans, neutrophil/lymphocyte/platelets count, D-dimer and CRP, cough was positively correlated with sputum production, and pulmonary abnormalities were positively correlated with CRP. White blood cell (WBC) count was also positively correlated with platelet counts, dyspnea, and neutrophil counts with the respective correlations of 0.668, 0.728, and 0.696. (4) Conclusions: This paper is the first systematic review and meta-analysis to reveal the relationship between various variables of clinical characteristics, symptoms and laboratory results with the largest number of papers and patients until now. In elderly patients, laboratory and clinical characteristics indicate a more severe disease course. Moreover, treatments such as antiviral agents, antibiotics, and oxygen therapy which are used in over three quarters of patients are also analyzed. The results will provide “evidence-based hope” on how to manage this unanticipated and overwhelming pandemic.

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Clinical and pathological characteristics of 2019 novel coronavirus disease (COVID-19): a systematic reviews

Cited by 29 publications

References 47 publications

2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission

2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission

Panic of Buying Toilet Papers: A Historical Memory or a Horrible Truth? Systematic Review of Gastrointestinal Manifestations of COVID-19

Correlations of Clinical and Laboratory Characteristics of COVID-19: A Systematic Review and Meta-Analysis

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