Clinical and Pathological Diagnosis of Hereditary Gastrointestinal Polyposis in Jack Russell Terriers

Yoneji, Wakana; Yoshizaki, Kyoko; Hirata, Akihiro; Yoneji, Kensuke; Sakai, Hiroki

doi:10.3390/vetsci9100551

Cited by 4 publications

(9 citation statements)

References 24 publications

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“…17 Unlike miniature Dachshunds or Jack Russell Terriers in Japan, Dachshunds and Jack Russell Terriers of our cohort were not found to be overrepresented. 20,26,27 Hematochezia, rectal bleeding or both abnormalities were consistently reported in this study, a similar finding to that reported in a study on colorectal adenocarcinomas in dogs. 19 However, diarrhea was only present in one quarter of the dogs.…”

Section: Discussionsupporting

confidence: 92%

“…We found that West Highland White Terriers were overrepresented among dogs with colorectal polyps, which was already suggested in a previous study, although this finding was solely based on the percentage of dogs of the breed among the diseased cohort 17 . Unlike miniature Dachshunds or Jack Russell Terriers in Japan, Dachshunds and Jack Russell Terriers of our cohort were not found to be overrepresented 20,26,27 …”

Section: Discussionsupporting

confidence: 80%

“…In a study on hereditary polyposis of Japanese Jack Russell Terriers, a high percentage of recurrence (7/11 dogs that underwent total surgical resection between 4 months and 2 years) was also reported 27 . In studies focusing on inflammatory colorectal polyps of Japanese Miniature Dachshunds either treated by immunosuppression or excised with or without additional immunosuppression, recurrence likewise seemed to be more frequent than the overall probability that we found 26,28 . Thus, West Highland White Terriers at least from France, and Miniature Dachshunds and Jack Russell Terriers at least from Japan might benefit from endoscopic surveillance after treatment of colorectal polyps.…”

Section: Discussionmentioning

confidence: 58%

“…27 In studies focusing on inflammatory colorectal polyps of Japanese Miniature Dachshunds either treated by immunosuppression or excised with or without additional immunosuppression, recurrence likewise seemed to be more frequent than the overall probability that we found. 26,28 Thus, West Highland White Terriers at least from France, and Miniature Dachshunds and Jack Russell Terriers at least from Japan might benefit from endoscopic surveillance after treatment of colorectal polyps. Similarly, dogs with larger polyps might be good candidates for endoscopic monitoring for recurrence.…”

Section: Multivariable Model P-valuementioning

confidence: 99%

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Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases

Méric,

Issard,

Maufras

et al. 2023

Veterinary Internal Medicne

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BackgroundCompared to humans, colorectal polyps are relatively rare in dogs. Epidemiological and prognostic data remain accordingly sparse, although they could help veterinary clinicians in the management of these cases.ObjectivesTo report the epidemiological data of dogs with colorectal polyps and identify factors associated with recurrence and survival.AnimalsFifty‐eight client‐owned dogs with colorectal polyps admitted to 7 veterinary hospitals (53 dogs from France, 5 dogs from Spain, and 4 dogs from Portugal) were included.MethodsRetrospective multicentric cohort study. Medical records and long‐term outcome of the dogs were reviewed. When available, histological samples were reassessed by 2 board‐certified pathologists according to the revised Vienna classification (RVC).ResultsThe West Highland White Terrier (WHWT) breed was significantly associated with the presence of colorectal polyps (OR: 20; 95% CI: 7.5‐52; P < .001). The overall median time to recurrence was not reached after 2000 days. The overall estimated median survival time was 1640 days. WHWT breed and larger polyps were significantly associated with a shorter time of polyp recurrence after surgical removal (respectively, P = .05 and P = .01).Conclusions and Clinical ImportanceThe probability of recurrence of colorectal polyps in dogs is low, but increased in WHWTs and larger polyps, which might benefit from routine screening after removal. No effective predictors of polyp recurrence and survival were identified using the RVC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 58%

Section: Multivariable Model P-valuementioning

confidence: 99%

See 2 more Smart Citations

Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases

Méric,

Issard,

Maufras

et al. 2023

Veterinary Internal Medicne

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“…In JRTs, this hereditary disease is characterized by the development of solitary and multiple polyps in the stomach and large intestine, with a predilection for the gastric antrum and rectum; multiple lesions can develop simultaneously at both locations [ 7 , 14 ]. Most lesions are histopathologically diagnosed as adenomas or adenocarcinomas [ 7 , 14 ]. Initial GI lesions can arise at variable ages, reportedly between 2 and above 10 years and at an average age of 7.7 years [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

First Evidence of Familial Transmission of Hereditary Gastrointestinal Polyposis Associated with Germline APC Variant in Jack Russell Terriers

Yoneji

Yoshizaki

Hirota

et al. 2023

Veterinary Sciences

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Jack Russell terriers (JRTs) with gastrointestinal (GI) neoplastic polyps have been recently reported to harbor an identical germline variant in the adenomatous polyposis coli (APC) gene, c.[462_463delinsTT], in the heterozygous state, which indicates that this disease is an autosomal dominant hereditary disorder. Many individual cases of this disease have been observed in clinical practice; however, familial transmission has not been demonstrated due to the difficulty in tracing the family members of household dogs, especially after the disease’s onset in adulthood. Recently, we encountered two cases of GI polyposis in maternal half sisters. These two cases facilitated the identification of additional relatives spanning three generations, including parents, full and half siblings of the dam (aunt and uncle), littermate and non-littermate siblings, and a nephew. Genetic analysis revealed that 11 of the 14 examined JRTs in this family carried the heterozygous germline APC variant, and eight dogs with the variant already had a current and/or past medical history of GI neoplastic polyps. Some cases in the family showed significantly more severe disease phenotypes than those initially reported, suggesting that the severity of this disease can vary considerably among individuals. Moreover, familial aggregation of severe cases suggested that the genetic modifier involved in increasing severity may have been transmitted in this family in addition to the germline APC variant. Furthermore, in addition to this family, we reported two other families of JRTs affected by hereditary GI polyposis that consisted of five full and half siblings and a mother–daughter pair, respectively. These findings unequivocally establish the transgenerational transmission of hereditary GI polyposis associated with the germline APC variant in JRT lineages.

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Canine colorectal proliferative lesions: A retrospective study of 217 cases

Fiedorowicz,

Czapula,

Domagała

2024

Preprint

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Colorectal proliferative lesions are not common in dogs. However, recently we have observed an increase in the number of diagnosed cases and a lack of publications providing current epidemiological data on changes of the large intestine in dogs. The aim of this study was a retrospective analysis of 217 canine colorectal non-neoplastic and neoplastic tumours, and assessment of the frequency of occurrence of individual lesions and whether there is a risk of their occurrence depending on age, sex, or dogs breed. Histopathological diagnosis was based on routine staining (hematoxylin and eosin) and appropriate immunohistochemistry when was necessary for definitive diagnosis. Half of the cases (52.5%) were malignant tumours with male predisposition and a significant predominance of adenocarcinoma (42.9%). In the group of malignant non-epithelial lesions, lymphoma and sarcomas predominated (4.1% and 4.1%, respectively) followed by three cases of plasmacytoma. Benign neoplastic tumours constituted almost one-third of all cases (26.7%) with obvious dominance of adenoma (24.0%) and young male predisposition. Benign mesenchymal tumours were represented only by leiomyoma (2.8%). The non-neoplastic lesions were represented by a heterogeneous group of polyps (20.3%) with a slight advantage of hyperplastic type (9.7%) and less numerous inflammatory, fibroblastic, lymphoid, and hamartomatous polyps. The one case of ganglioneuromatosis in hamartomatous polyp was diagnosed. Non-neoplastic lesions were frequently diagnosed in female. We have observed for the first time that French Bulldogs are susceptible to developing colorectal proliferative lesions, including adenomas, adenocarcinomas and polyps. The results of our research provided new data expanding knowledge about the epidemiology of colorectal neoplastic and non-neoplastic proliferative lesion in dogs. We were also able to determine sex- and breed-specific risk factors associated with the occurrence of adenocarcinomas, adenomas, and non-neoplastic polyps. Our results are alarming and imply the necessity of implement routine colonoscopy in dogs in early detection of lesion and prevention of the development and progression of malignant tumours.

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Clinical and Pathological Diagnosis of Hereditary Gastrointestinal Polyposis in Jack Russell Terriers

Cited by 4 publications

References 24 publications

Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases

Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases

First Evidence of Familial Transmission of Hereditary Gastrointestinal Polyposis Associated with Germline APC Variant in Jack Russell Terriers

Canine colorectal proliferative lesions: A retrospective study of 217 cases

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