Clinical and Pathological Factors Related to the Prognosis of Chinese Patients with Stage Ⅰb To Ⅱb Cervical Cancer

Xie, Xiaoyan; Song, Kun; Cui, Baoxia; Jiang, Jie; Zhang, Youzhong; Wang, Bo; Yang, Xingsheng; Kong, Beihua

doi:10.7314/apjcp.2012.13.11.5505

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…All of these factors have been documented to be the powerful variables related to CC progression and compromise long-term survival [39–42]. Herein, high NLR is closely associated with more aggressive tumor behavior which is contributed to shorter OS and PFS.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of the pretreatment neutrophil-to-lymphocyte ratio in cervical cancer: a meta-analysis and systematic review

et al. 2017

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The prognostic value of pretreatment neutrophil-to-lymphocyte ratio (NLR) in cervical cancer remains controversial. We conducted a meta-analysis based on the data from 13 studies with 3729 patients to evaluate the association between the pretreatment NLR and the clinical outcomes of overall survival and progression-free survival in patients with cervical cancer. The relationship between NLR and clinicopathological parameters was also assessed. Hazard ratio (HR) or odds ratio (OR) with its 95% confidence interval (CI) was used as the effect size estimate. Our analysis indicated that elevated pretreatment NLR was a poor prognostic marker for patients with cervical cancer because it predicted unfavorable overall survival (HR = 1.375, 95% CI: 1.200–1.576) and progression-free survival (HR = 1.646, 95% CI: 1.313–2.065). Increased NLR is also significantly associated with the larger tumor size (OR = 1.780, 95% CI: 1.090–2.908), advanced clinical stage (OR = 2.443, 95% CI: 1.730–3.451), and positive lymph node metastasis (OR = 2.380, 95% CI: 1.775–3.190). By these results, high pretreatment NLR predicted a shorter survival period for patients with cervical cancer, and it could be served as a novel index of prognostic evaluation in patients with cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of the pretreatment neutrophil-to-lymphocyte ratio in cervical cancer: a meta-analysis and systematic review

et al. 2017

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“…In stage IB-IIA cervical carcinoma after either radiotherapy (RT) prognosis are excellent with a 5-year overall survival ratio of 78-91 % (Landoni et al, 1997). Some reports have shown that patients with adenocarcinoma have a poorer prognosis than SCC histology (Kleine et al, 1989;Eifel et al, 1990;Hopkins and Morley, 1991;Eifel et al, 1995;Irie et al, 2000;Nakanishi et al, 2000;Xie et al, 2012;Intaraphet et al, 2013). In another study, it was reported that the recurrence rate of the pure AC group was higher than in the SCC (Lee et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

Teke¹,

Yöney²,

Teke³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Multivariate analysis using a Cox-proportional hazards model was used to adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI). Results:There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrial invasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-year OS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p> 0.05). Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resection margin status for OS (p=0.008, p=0.002, respectively). Conclusions: Prognosis of FIGO stage IA-IIB cervical cancer patients was found to be the same for those with adenocarcinoma and SCC.

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“…A study by Lim et al found that a more extensive lymphadenectomy (>40 ELNs) improved survival in patients with tumors sized >4 cm 21. However, other studies found that the ELN count had no effect on survival 13–15. In this study, we found that a higher number of ELNs was associated with better survival in patients with early stage cervical cancer.…”

Section: Discussionmentioning

confidence: 38%

“…Previous studies have found that a higher number of ELNs was associated with better survival in patients with node-positive disease 11,12. However, several studies have shown that extensive lymphadenectomy did not improve survival 13–15. In addition, a population-based study found that a higher number of ELNs was associated with better survival outcomes in patients with node-negative cervical cancer 16.…”

Section: Introductionmentioning

confidence: 99%

The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix

Zhou¹,

Zhang²,

Wu³

et al. 2017

CMAR

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IntroductionThe prognostic impact of the number of examined lymph nodes (ELNs) in different histological subtypes of cervical cancer remains unclear. We aimed to assess the impact of the number of ELNs in stage IA2–IIA cervical cancer with different histological subtypes.MethodsData of patients with stage IA2–IIA squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the uterine cervix between 1988 and 2013 were retrieved from the Surveillance, Epidemiology, and End Results program. Univariate and multivariate Cox regression analyses were performed to analyze the effect of number of ELNs on cause-specific survival (CSS) and overall survival (OS).ResultsThe final data set identified 11,830 patients including 7,920 (66.9%) women with SCC and 3,910 (33.1%) with AC. The median number of ELNs was 19. The multivariate analysis indicated that the number of ELNs was an independent prognostic factor influencing CSS and OS, both as a continuous or a categorical variable. Patients with a higher number of ELNs had better survival outcomes. In SCC subtype, the number of ELNs was also the independent prognostic factor of CSS and OS in node-positive patients, but not in patients with node-negative disease. In AC patients, ELN count was not an independent predictor of CSS and OS regardless of lymph node status.ConclusionThe number of ELNs is an independent prognostic factor in patients with stage IA2–IIB cervical cancer. A higher number of ELNs is associated with better survival outcomes, especially in the node-positive SCC subtype.

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Clinical and Pathological Factors Related to the Prognosis of Chinese Patients with Stage Ⅰb To Ⅱb Cervical Cancer

Cited by 13 publications

References 15 publications

Prognostic value of the pretreatment neutrophil-to-lymphocyte ratio in cervical cancer: a meta-analysis and systematic review

Prognostic value of the pretreatment neutrophil-to-lymphocyte ratio in cervical cancer: a meta-analysis and systematic review

Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix

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