Clinical and Pathological Features of 14 Non-Hodgkinʼs Lymphomas Associated With Coeliac Disease

Sonet, Anne; Théate, Ivan; Delos, Monique; Montfort, Luc; Mineur, Philippe; Driesschaert, P.; Michaux, Lucienne; Ferrant, Augustin; Bosly, André

doi:10.1179/acb.2004.021

Cited by 4 publications

(5 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rising incidence of EATL is concerning, particularly in light of the poor survival. We found a median survival of 6 months, which is consistent with the existing literature, which shows a range of median survival of 5–12 months (4,5,7,19,20,22,24,28,30). Strikingly, we found that year of diagnosis did not affect survival, indicating that outcomes in EATL have not improved over the past 2 decades.…”

Section: Discussionsupporting

confidence: 91%

“…EATL and celiac disease are closely connected, with celiac disease being found in 38%-100% of those with EATL (4,24,26). Celiac disease can be diagnosed months to years before EATL or diagnosed simultaneously (2,(26)(27)(28). Most commonly, EATL develops in roughly 50% of those with refractory celiac disease type II, and this process is believed to be driven by activating mutations in the JAK/STAT pathway leading to dysregulated cytokine signaling and a fundamental role of interleukin-15 (23,26,(29)(30)(31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Rising Incidence and Poor Outcomes of Enteropathy-Associated T-Cell Lymphoma

Hujoel,

Hujoel

2024

Am J Gastroenterol

View full text Add to dashboard Cite

Introduction: Enteropathy-associated T-cell Lymphoma (EATL) is associated with celiac disease. With the rising prevalence of celiac disease, we hypothesized that the prevalence of EATL is also increasing. Methods: We used the Surveillance, Epidemiology, and End Results (SEER) database, which is a population-based United States (US) cancer surveillance program. We used the ICD-O3 code 9717/3 to identify patients with EATL diagnosed between 2000 and 2020. Incidence rates were calculated using the SEER*Stat software and annual percent change was calculated using the Joinpoint software. Log-rank tests were used to evaluate for significant difference in survival curves between groups. A cox-proportional hazards regression model was used for continuous variables and quantifying association strength of predictors. Results: 463 cases of EATL were identified (273 male, 190 female) with a median age of 65 (range 23-90+). The majority of cases were at an advanced stage at diagnosis and were treated with a combination of surgery and chemotherapy. Median survival time was 6 months. The 2000-2020 age-adjusted incidence rate per 100,000 people was 0.014, and the incidence increased between 2000 and 2020, with an annual percent change of 2.58 (p<0.05). Increased age at diagnosis and lack of treatment had significant impacts on survival while sex, year of diagnosis, race, and time between diagnosis and treatment had no significant impact on survival. Discussion: There was a significant increase in the incidence of EATL in the US between 2000 and 2020. Survival of EATL remains poor and unchanged over the past two decades.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The Rising Incidence and Poor Outcomes of Enteropathy-Associated T-Cell Lymphoma

Hujoel,

Hujoel

2024

Am J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…As the presence of enhanced levels of CIC in this work was especially found in patients with NHL, and was also reported in other publications [19], it seems that in people where antibody immunoreactivity is present in the form of immune complexes could be an enhanced immune stimulation elicited by these CIC. Data on the immunoreactivity to gliadin antigens are in accordance with well known association of gluten intolerance and NHL [13,20]. It is especially important to note that in this work, the immunoreactivity with gliadin is found to be present in patients with B cell type NHL, mostly in diffuse large B cell NHL as this type in this study was the most common one, which are along with the data of Smedby et al [21], in the presence of celiac disease in patients with mentioned type of NHL.…”

Section: Discussionsupporting

confidence: 82%

“…Strictly, Burkkit's lymphoma is found to be associated with Epstein Barr virus, MALT lymphoma with Helicobacter pylori, while primary effusion lymphoma was found to be associated with human herpes virus type 8 [1,6]. From the other side, the association of some of autoimmune diseases such as lupus, psoriasis, Sjögren's syndrome, with NHL, is also well documented in recent papers [7][8][9][10][11][12][13]. The association of celiac disease is also reported in diffuse large B cell NHL as well as in enteropathy-associated T cell NHL [12,13].…”

Section: Introductionmentioning

confidence: 83%

Some patients with NHL possessed immunoreactivity to gliadin and to cow’s milk proteins

et al. 2009

View full text Add to dashboard Cite

Non-Hodgkin lymphoma (NHL) represents heterogeneous group of diseases either B, or T cell origin. In order to assess whether food antigens contribute to the imbalance of immune response, the aim of this work was screening the sera of patients with (mostly) B cell NHL, and of people with non-malignant health disorders (NMD), as well as of healthy people for their immunoreactivity to food constituent gliadin, and to cow's milk proteins. Data obtained by ELISA tests show the existence of the enhanced immunoreactivity to food antigens in some NHL patients, as well as in some people with NMD. The high degree of coincidence in the presence of enhanced levels of immune complexes in circulation (CIC) and of immunoreactivity with gliadin in immunofixation (after the serum protein electrophoresis in agarose gel in veronal buffer, at pH 8.6) especially in NHL patients points that some antigliadin immunoreactivity unrevealed in ELISA tests could be hidden in CIC. This, only in the presence of malignant genotype, as well as the enhanced levels of CIC in some of NHL patients could both, at least partially contribute to the persistent non-specific support of disease. They call for the new research of the clinical importance of both, the elevated humoral immunity to food antigens (gluten, cow's milk proteins) for the course of this very severe hematological disease.

show abstract

“…Case series of patients with NHL associated with CD have yielded variable results but suggested that selected patients may enjoy prolonged survival. 148,151,152,169,170 One study suggested that the prognosis of stage IV NHL was worse in patients with CD compared with those without CD. 169 Therapy of ETL is currently unsatisfactory, with a 5-year survival ranging from 11% to 20% in 2 studies and a 2-year survival of 28% according to another study.…”

Section: Lymphomamentioning

confidence: 99%

Hematologic manifestations of celiac disease

Halfdanarson¹,

Litzow²,

Murray

2006

Blood

322

281

View full text Add to dashboard Cite

Celiac disease is a common systemic disorder that can have multiple hematologic manifestations. Patients with celiac disease may present to hematologists for evaluation of various hematologic problems prior to receiving a diagnosis of celiac disease. Anemia secondary to malabsorption of iron, folic acid, and/or vitamin B12 is a common complication of celiac disease and many patients have anemia at the time of diagnosis. Celiac disease may also be associated with thrombocytosis, thrombocytopenia, leukopenia, venous thromboembolism, hyposplenism, and IgA deficiency. Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type. The risk is highest for enteropathy-type T-cell lymphoma (ETL) and B-cell lymphoma of the gut, but extraintestinal lymphomas can also be seen. ETL is an aggressive disease with poor prognosis, but strict adherence to a gluten-free diet may prevent its occurrence.

show abstract

Clinical and Pathological Features of 14 Non-Hodgkinʼs Lymphomas Associated With Coeliac Disease

Cited by 4 publications

References 42 publications

The Rising Incidence and Poor Outcomes of Enteropathy-Associated T-Cell Lymphoma

The Rising Incidence and Poor Outcomes of Enteropathy-Associated T-Cell Lymphoma

Some patients with NHL possessed immunoreactivity to gliadin and to cow’s milk proteins

Hematologic manifestations of celiac disease

Contact Info

Product

Resources

About