Clinical and pathological observations concerning the aetiology of primary lens luxation in the dog

Abstract

A series of 123 consecutive referred cases of lens dislocation in the dog were classified as primary (100), secondary (21) and congenital (two). Cases designated as primary lens luxation comprised only the terrier breeds or crossbreds and collectively appeared to represent a single clinical entity characterised by age of onset (mean four to five years), essential bilaterality and the apparent absence of antecedent ocular disease. Elevated intraocular pressures were encountered in many eyes exhibiting subluxation. However, in three Tibetan terriers, on which tonometry was performed on a daily basis for approximately one year during the period of subluxation and before the development of luxation, there was no evidence of abnormal intraocular pressure change, suggesting that ocular hypertension in primary lens luxation is a secondary and not a primary development. All but one of nine affected eyes representing three terrier breeds showed abnormalities of the suspensory apparatus of the lens (zonule) which resembled those reported previously in Tibetan terriers bred for the condition.

Primary Lens Luxation in Australian Tenterfield and Miniature Bull Terriers is Due to An Old ADAMTS17 Mutation and is an Additive Trait

“…The disease is common in Terrier breeds such as the Tibetan Terrier, Miniature Bull Terrier and Jack Russell Terrier; but has also been reported in non-Terrier breeds such as the Chinese Shar Pei and Australian Cattle Dog. Primary Lens Luxation is usually first diagnosed in dogs when they are 2-6 years old, with the average age being 4.7-5.2 years [3,4].…”

Penetrating eye injury in a dog: a case report

“…Vitreous displacement may additionally provoke obstruction at the trabecular meshwork level (Manning et al 2006). These complications may cause a blockage of the aqueous outflow, a rapid IOP increase and quite severe pain (Curtis et al 1983;Bedford 1988;Nasisse and Glover 1997). As discussed in this case, posterior lens subluxation could have also caused retinal damage (Curtis et al 1983;Bedford 1988).…”

“…These complications may cause a blockage of the aqueous outflow, a rapid IOP increase and quite severe pain (Curtis et al 1983;Bedford 1988;Nasisse and Glover 1997). As discussed in this case, posterior lens subluxation could have also caused retinal damage (Curtis et al 1983;Bedford 1988). For these reasons, rapid removal of a displacement lens is commonly recommended (Glover et al 1995;Pizzirani 1998).…”

“…Secondary glaucoma and ocular hypertension may occur as a complication of phacoclastic uveitis and lens subluxation as well as anterior hyaloid face damage. A protruded vitreous as well as a subluxated lens may cause a pupillary block, anterior displacement of the iris base and a narrowing of the ciliary cleft (Curtis et al 1983;Bedford 1988). Vitreous displacement may additionally provoke obstruction at the trabecular meshwork level (Manning et al 2006).…”

“…This was to prevent the above-described papillary (Curtis et al 1983;Bedford 1988;Gelatt and Gelatt 2001b) and potential trabecular meshwork blockage (Manning et al 2006). A similar pupillary block and a subsequent sudden increase in IOP up to 65 mmHg, was reported in the clinical case of a Boston Terrier puppy with a corneal perforation, iris prolapse and anterior lens capsule disruption (Denis 2002).…”