Clinical and Pathological Presentations of Bronchogenic Carcinoma in a Tertiary Care Centre

Pujari, Vishwanath; M, Rahul Lokhande; H, Sushant Meshram; D, Rakesh Waghmare

doi:10.14260/jemds/2016/692

Cited by 4 publications

(7 citation statements)

References 6 publications

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“…1 The result of current study demonstrated that the pathological types of bronchogenic carcinoma have changed as ADC (30.9%) has nearly equal prevalence to SCC (31.7%), followed by LCC (26.0%), while SCLC was the least prevalent type (11.4%). Similarly, several studies reported higher prevalence of SCC and ADC.…”

Section: Discussionmentioning

confidence: 60%

“…Similar delay in presentation up to 3-4 months was reported in other studies with only 2.5 % of patients were asymptomatic. 1,3,16,21 Cough and chest were the main presenting symptoms among our patients irrespective to pathological types (p=0.8). The mechanism of cough is multifactorial as it may be due to either local growth in a centrally locating tumours (e.g.…”

Section: Discussionmentioning

confidence: 64%

“…Similarly, other studies reported that cough was the most common presenting symptoms. 1,23 The mediastinal compression symptoms (dyspnea, dysphonia, dysphagia) and vocal cord paralysis were significantly highest in SCLC and SCC (p<0.05). This is due to which both SCLC and SCC are mainly centrally locating tumours (table 5) that cause compression of a major airways, trachea, esophagus and recurrent laryngeal nerve.…”

Section: Discussionmentioning

confidence: 98%

“…6,[15][16][17][18][19][20][21] Moreover, in some Asian and western countries, ADC has surpassed SCC as the most common subtype. 1,23,24 This shift in incidence of SCC and ADC may be due to switch from non-filtered to filtered cigarettes. Smoke from unfiltered strong cigarettes may be shallowly inhaled, resulting in carcinogen deposition in the central bronchi giving rise to SCC.…”

Section: Discussionmentioning

confidence: 99%

“…1 Cigarette smoking is the major cause of lung cancer; 95% of patients are smokers. 2 At presentation, 85% of the patients are symptomatic.…”

Section: Introductionmentioning

confidence: 99%

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Clinical, radiological, laboratory and bronchoscopic features characterizing each type of bronchogenic carcinoma

Hafez¹,

Abo-Elkheir²

2017

Int J Res Med Sci

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Background: To analyse the clinical, radiological, laboratory, and bronchoscopic findings characterizing each type of bronchogenic carcinoma.Methods: A cross-sectional study was conducted on 123 bronchogenic carcinoma patients. They were subjected to history taking, laboratory investigations, computed tomographic scan and fiberoptic bronchoscopy.Results: The mean age of the patients was 56.9±6.7 years, 76.4% were males and 78.9% were smokers. Most of them were symptomatic, adenocarcinoma (ADC) being the highest symptomatic one. Expectoration, fingers clubbing, and fever were common in ADC and small cell lung cancer (SCLC). Dyspnea, haemoptysis, dysphonia, dysphagia, vocal cord paralysis, anorexia and weight loss were common in SCLC and squamous cell carcinoma (SCC). Deep venous thrombosis was common in ADC and SCC. Mass lesion, atelectasis, chest wall invasion and elevated hemidiaphragm were common in SCLC and SCC. Ipsilateral mediastinal lymph nodes enlargement, cavitary lesion, and apical lesion were common in SCC and ADC. Contralateral mediastinal lymph nodes enlargement was common in SCLC. Nodular lesion, consolidation and pleural effusion were common in ADC. Hypercalcemia and hyponatremia were common in SCC. Malignant pleural effusion was common in ADC. Most of the patients had bronchoscopically-visible lesions; SCLC and SCC being the highest visible types. Most of the SCC and SCLC were centrally located, while LCC and ADC were mainly peripherally located. Most of cases were diagnosed via bronchoscopy. More than half of the studied cases were inoperable at presentation, especially SCLC and SCC.Conclusions: The 4 pathological types are distinguished from each other’s by certain clinical, radiological, laboratory and bronchoscopic features.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

“…1 Cigarette smoking is the major cause of lung cancer; 95% of patients are smokers. 2 At presentation, 85% of the patients are symptomatic.…”

Section: Introductionmentioning

confidence: 99%

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Clinical, radiological, laboratory and bronchoscopic features characterizing each type of bronchogenic carcinoma

Hafez¹,

Abo-Elkheir²

2017

Int J Res Med Sci

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D-Dimer; A Potential Clinical Marker for Predicting Metastasis & Stages in Lung Cancer

Aftab¹

2019

LOJPCR

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The relationship between plasma D-dimer level and the prognosis of advanced lung cancer is close to each other. This study investigated the role of plasma D-dimer as a prognostic factor in advanced lung cancer: a) The aim of the current study was to investigate the association of D dimer plasma level with the development of stages in lung cancer. b) D-dimers levels as predictor of fibrinolysis and Disseminated Intravascular Coagulation (DIC). The subjects were selected from oncology department, Ghulab Devi Hospital and Mayo Hospital, Lahore. Total 45 subjects were included in the present study. The selected subjects were divided into two groups. Group A included 15 normal, healthy, age and sex matched controls and group B included 30 patients, histologically diagnosed cases of lung cancer. The patients had no history of coagulation disorders or on anti-coagulant therapy. The plasma D-dimer was measured in normal, heathy Controls and 30 histologically diagnosed cases of lung cancer by enzyme-linked immunosorbent assay. The median age of the patients (18 males and 12 females ) was 39.433± 5.11 and 13.3% had stage lb, 20% had llb, 6.7 % llla, 36.11 lllb, 23.3 % had lV disease. Histologic sub-type was Non-small cell lung carcinoma (NSCLC) 30 %, Small cell lung carcinoma (SCLC) were 10 %, Squamous cell carcinoma were 10 %, adenocarcinoma 16.7 % and large cells carcinoma were 10%.In the present study. The Mean ± SD value of D-dimer level of the patients was 1068.70±441.86ng/dl, which was significantly higher than that of the control group. The plasma levels of D-dimer were significantly higher in patients with bronchogenic carcinoma as compared with healthy controls. Plasma D-dimer level was significantly higher in metastatic disease (P <0.01). D dimer levels were positively associated with clinical cancer stage (P<0.05) and metastasis (P<0.05). These findings suggested that the plasma D dimer level may be use as marker for predicting cancer metastasis and staging in lung cancer.

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Clinicopathological Profile of Patients with Bronchogenic Carcinoma at a Tertiary Care Center in Western India

Thakkar¹,

Damor²,

Vithalani³

2022

Indian Journal of Respiratory Care

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Clinical and Pathological Presentations of Bronchogenic Carcinoma in a Tertiary Care Centre

Cited by 4 publications

References 6 publications

Clinical, radiological, laboratory and bronchoscopic features characterizing each type of bronchogenic carcinoma

Clinical, radiological, laboratory and bronchoscopic features characterizing each type of bronchogenic carcinoma

D-Dimer; A Potential Clinical Marker for Predicting Metastasis & Stages in Lung Cancer

Clinicopathological Profile of Patients with Bronchogenic Carcinoma at a Tertiary Care Center in Western India

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