Clinical and pathological staging of gastric cancer: Current perspectives and implications

Zhu, Zhi; Gong, Yantao

doi:10.1016/j.ejso.2020.06.006

Cited by 23 publications

(14 citation statements)

References 37 publications

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“…As for the influence of invasion depth on the accuracy of N staging, it was found that with the increase of tumor invasion depth, the detection error rate of metastatic lymph nodes increased substantially. When the tumor invaded the muscularis propria and subserosal layer, the proportion increased substantially, which was consistent with the results of Zhu et al [18]. The reasons are as follows.…”

Section: Discussionsupporting

confidence: 91%

The Value of Gastric Cancer Staging by Endoscopic Ultrasonography Features in the Diagnosis of Gastroenterology

Zhou

2022

Computational and Mathematical Methods in Medicine

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This research was aimed at exploring the application value of endoscopic ultrasonography (EUS) in the diagnosis of gastric cancer staging and the correlation between staging and clinical features of gastric cancer. A total of 72 patients with gastric cancer were selected and randomly divided into two groups. The patients in the pathological group underwent postoperative pathological examination, while those in the EUS group received preoperative EUS examination. The results showed that the staging accuracy of EUS was 73.33% for T1, 78.57% for T2, 27% for T3, and 100% for T4, compared with the pathological staging. The accuracy of N- and N+ was 42.5% and 82.3% in EUS, respectively, and the total accuracy was 55.7%. There was no considerable difference in the accuracy of T staging between early gastric cancer and advanced gastric cancer ( P > 0.05 ), but there was a considerable difference in N staging ( P < 0.05 ). Lymph node metastasis affected the accuracy of N staging ( P < 0.05 ). The number and location of metastatic lymph nodes did not affect the judgment of metastatic lymph nodes ( P > 0.05 ). In addition, the proportion of understaging and overstaging was greatly different among different lesion sizes and histological types of gastric cancer ( P < 0.05 ). To sum up, the accuracy of EUS for T and N staging of gastric cancer needed to be improved. The location of gastric cancer lesions affected the accuracy of T staging, while the depth of invasion and lymph node metastasis affected the accuracy of N staging.

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Section: Discussionsupporting

confidence: 91%

The Value of Gastric Cancer Staging by Endoscopic Ultrasonography Features in the Diagnosis of Gastroenterology

Zhou

2022

Computational and Mathematical Methods in Medicine

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“…La recaída se presentó en el 48% de pacientes siendo la más frecuente a nivel hepático y ganglionar lo cual fue un factor de mal pronóstico con una alta tasa de mortalidad (28) .…”

Section: Discussionunclassified

Epidemiología Del Cáncer De Estómago en Un Centro De Referencia Del Ecuador.

Acuña¹,

Solís²,

Oñate³

et al. 2021

RMV

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IntroductionGastric cancer is the most common malignant tumor in Ecuador. Despite advances in diagnostic methods and cancer therapies, most cases are diagnosed in advanced stages of the disease with poor prognosis and high mortality. The objective of this study was to determine epidemiological characteristics in patients treated with gastric cancer at a reference center in Ecuador.Patients and methodsIt was a cross-sectional retrospective study, patients were eligible in the Oncology Service of the Hospital de Especialidades Eugenio Espejo (HEEE) between March 2012 and March 2017. data were collected from medical records.Resultsduring the study period 159 patients were evaluated, the median age was 61 years and 52.80% were male. The most common symptom of diagnosis was abdominal pain in 59% of cases. The stage of the disease in 72% of patients was regionally advanced and widespread. Those patients who underwent surgery; presented more survival. Conclusions 50% of cases were diagnosed in advanced stages of the disease and were associated with poor prognosis and high mortality. The clinical and epidemiological characteristics of this first study carried out in the HEEE, will allow to establish measures to improve the screening and early diagnosis of patients.

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“…Various carcinomas metastasize to local and distant organs and regions of the body through the lymphatic system [ 94 ]. Often, lymph node metastasis is used to stage cancer as seen through the use of the TNM staging system, where N represents the spread of cancer to adjacent lymph nodes [ 95 ]. Through this system, physicians are able to determine the prognosis and precise treatment protocols of specific cancers.…”

Section: Colorectal Neoplasia and Metastasismentioning

confidence: 99%

Bacterial Involvement in Progression and Metastasis of Colorectal Neoplasia

Seely

Morgan

Hagenstein

et al. 2022

Cancers

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While the gut microbiome is composed of numerous bacteria, specific bacteria within the gut may play a significant role in carcinogenesis, progression, and metastasis of colorectal carcinoma (CRC). Certain microbial species are known to be associated with specific cancers; however, the interrelationship between bacteria and metastasis is still enigmatic. Mounting evidence suggests that bacteria participate in cancer organotropism during solid tumor metastasis. A critical review of the literature was conducted to better characterize what is known about bacteria populating a distant site and whether a tumor depends upon the same microenvironment during or after metastasis. The processes of carcinogenesis, tumor growth and metastatic spread in the setting of bacterial infection were examined in detail. The literature was scrutinized to discover the role of the lymphatic and venous systems in tumor metastasis and how microbes affect these processes. Some bacteria have a potent ability to enhance epithelial–mesenchymal transition, a critical step in the metastatic cascade. Bacteria also can modify the microenvironment and the local immune profile at a metastatic site. Early targeted antibiotic therapy should be further investigated as a measure to prevent metastatic spread in the setting of bacterial infection.

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Clinical and pathological staging of gastric cancer: Current perspectives and implications

Cited by 23 publications

References 37 publications

The Value of Gastric Cancer Staging by Endoscopic Ultrasonography Features in the Diagnosis of Gastroenterology

The Value of Gastric Cancer Staging by Endoscopic Ultrasonography Features in the Diagnosis of Gastroenterology

Epidemiología Del Cáncer De Estómago en Un Centro De Referencia Del Ecuador.

Bacterial Involvement in Progression and Metastasis of Colorectal Neoplasia

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