Clinical and pathology analysis of 1 case of adult pleural pulmonary blastoma

Liu, Yi; Dong-bo, Luo; Du, Tongxin; Wang, Hongjiang

doi:10.1097/md.0000000000008918

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…It is known to grow rapidly and be problematic at the time of diagnosis due to its two-phase localization and construction [2]. PPB is ideally found in children, and its findings in adults are usually rare [2, 3].…”

Section: Discussionmentioning

confidence: 99%

Metachronous pleuropulmonary blastoma in an adult patient with endometrial cancer: a case report

Bhalerao

Adhav

Gandhe

2019

Oxford Medical Case Reports

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Pulmonary blastoma is a rare form of lung cancer with a reported incidence of 0.25–0.55 of primary pulmonary cancers. Pleuropulmonary blastoma (PPB) is a common finding in children while it is rarely found in adults. In the past few years, the incidence of a second primary tumour has increased to 3.5% followed by third primary tumour at 0.5% and fourth tumour at 0.3%. The clinical significance of diagnosing and distinguishing a secondary primary tumour is often challenging. As per our knowledge, this is the first case of metachronous PPB in an adult patient previously diagnosed with endometrial cancer.

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Section: Discussionmentioning

confidence: 99%

Metachronous pleuropulmonary blastoma in an adult patient with endometrial cancer: a case report

Bhalerao

Adhav

Gandhe

2019

Oxford Medical Case Reports

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“…There is a similarity in the anatomical presentation of these tumors. Involvement of the upper lobes, restriction to only one lung, and mean tumor size of 7-10cm are some of them [8,[26][27][28]. Hematogeneous metastases in the brain, bones, and liver, similar to NSCLC, but also in the breast, ovaries, peritoneum have been reported [8,29].…”

Section: Clinical and Radiographic Characteristicsmentioning

confidence: 99%

Pulmonary Blastoma: A Comprehensive Overview of A Rare Entity

Tsamis

Chachali

Gomatou

et al. 2021

Advances in Respiratory Medicine

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Introduction: Pulmonary blastoma is a rare malignancy, accounting for less than 0.5% of primary lung tumors. It belongs to the group of pulmonary sarcomatoid carcinomas, and it is typically characterized by a biphasic pattern of an epithelial and a mesenchymal component. Only a few hundred cases have been reported worldwide. The aim of this study is to review and critically assess the literature regarding pulmonary blastoma. Material and methods: A narrative literature review of PubMed database from the inception of the database up to January 2021, limited to the English language, was conducted, using combinations of the following keywords: “pulmonary blastoma”, “biphasic pulmonary blastoma”, “sarcomatoid carcinoma”. Results: Pulmonary blastoma is composed of an epithelial and a mesenchymal malignant component. Regarding pathogenesis, the origin of the biphasic cell population remains elusive. Characteristic immunohistochemical stains are supportive of diagnosis.Clinically, the symptomatology is non-specific, while 40% of the cases are asymptomatic. It is diagnosed at a younger agecompared to other types of lung cancer, and it is often non-metastatic at diagnosis allowing for surgical treatment. Data on management and survival are scarce and mainly come from isolated cases. Advances on targeted therapy may provide novel treatment options. Given the rarity of the cases, multicenter collaboration is needed in order to establish therapeutic Guideliness.

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“…Монофазна легенева бластома, яку ще називають епітеліальною або добре диференційованою аденокарциномою, містить лише злоякісні епітеліальні компонен ти. Дитяча плевропульмональна бластома -це монофазна легенева бластома, що містить тіль ки оригінальну мезенхімальну тканину [5]. Однак рак легень, який спостерігається в дорос лих, рідко зустрічається в дітей; хоча трапляєть ся і тяжко диференціюється.…”

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“…Приблизно 60% хворих відміча ють неспецифічні симптоми [8]. Спільні клініч ні характеристики в пацієнтів, які мали вказа ний діагноз та описані в літературних джерелах, є неспецифічними та включали: кашель, втому, кров у мокротинні, стиснення та біль у грудях, задишку, втрату ваги в анамнезі [2,5,7], які повільно прогресували та часто ставали причи ною встановлення хибних діагнозів. Під час рентгенологічного дослідження грудної клітки зазвичай виявляється аномальна тінь у легене вому полі, затемнення, ознаки пневмотораксу [7].…”

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Clinical case of pulmonary blastoma in a child as a disguise of community-acquired pneumonia

Dutchuk¹,

Kocherha²,

Voloshynovych³

et al. 2021

MPU

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Currently, the problem of diagnosing pleuropulmonary blastoma in children remains relevant, because this pathology often runs under the guise of other nosologies, including pneumonia, and is extremely difficult to diagnose. Currently there are no pathognomonic clinical symptoms, specific diagnostic criteria for this disease, almost 60% of patients have nonspecific symptoms. This article presents a rare clinical case of biphasic pulmonary blastoma in a child who was examined and treated at the Ivano-Frankivsk Regional Children's Clinikal Hospital Ivano-Frankivsk Regional Council. The main clinical manifestations, diagnosis and treatment of biphasic blastoma of the lungs in a child based on the observation of a 5-year-old girl who was hospitalized for acute abdominal pain, chest pain and cough. After clinical — laboratory and instrumental methods of examination, right-sided pneumonia and exudative pleurisy were diagnosed. The set of treatment measures did not give the expected positive effect, improving the patient's condition. Additional testing is required for suspected breast cancer. It has been established that the best method for verifying the diagnosis of pulmonary blastoma is multislice computed tomography with intravenous bolus contrast and immunohistochemical examination of the biopsy. The methods of treatment used in this case, including anti-inflammatory and polychemotherapy according to the scheme, the use of radical treatment at the National Cancer Institute in Kyiv — surgery right pneumonectomy with pericardial resection. The child is currently in stable remission for 4.5 years. The described clinical case demonstrates the difficulty of diagnosing lung blastoma in children due to the lack of typical clinical manifestations. The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: children, pneumonia, blastoma, pulmonology, diagnosis, treatment.

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Clinical and pathology analysis of 1 case of adult pleural pulmonary blastoma

Cited by 4 publications

References 11 publications

Metachronous pleuropulmonary blastoma in an adult patient with endometrial cancer: a case report

Metachronous pleuropulmonary blastoma in an adult patient with endometrial cancer: a case report

Pulmonary Blastoma: A Comprehensive Overview of A Rare Entity

Clinical case of pulmonary blastoma in a child as a disguise of community-acquired pneumonia

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