Clinical and perinatal outcomes of fresh single-blastocyst-transfer cycles under an early follicular phase prolonged protocol according to day of trigger estradiol levels

Ying, Yingfen; Lu, Xiaosheng; Zhang, Huina; Arhin, Samuel Kofi; Hou, Xiaohong; Wang, Zefan; Wu, Han; Lu, Jieqiang; Tang, Yunbing

doi:10.7717/peerj.11785

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…YF Ying et al has shown that the E2 level on hCG day may be related to the incidence of ovarian hyperstimulation syndrome (OHSS) [ 31 ]. So, will high E2 level affect birthweight through the high incidence of OHSS?…”

Section: Discussionmentioning

confidence: 99%

E2 level > 2950 pg/ml on hCG trigger day is an independent predictor for birthweight loss of full-term singletons born after fresh embryo transfers in non-PCOS patients

Zhang

Wang

2022

Reprod Biol Endocrinol

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Background Previous studies have demonstrated that the supraphysiological E2 level is negatively correlated with birthweight. However, the cut-off value of E2 level that significantly affects birthweight is unknown, and there is no definite conclusion regarding this level. Our study aimed to explore the threshold of the effect of E2 levels on birthweight. Design A retrospective cohort study of 1846 samples was performed. All patients ≤42-years-old underwent autologous IVF cycles between August 1st, 2016 and April 30th, 2020. We categorized our data into four groups according to the E2 level: Group 1: ≤2000 pg/mL; Group 2: 2001–3000 pg/mL; Group 3: 3001–4000 pg/mL; and Group 4: > 4000 pg/mL. Results The results of the multivariate regression analyses showed that when the E2 level was 3001–4000 pg/mL (adjusted β: − 89.64, 95% [CI]: − 180.29 to − 6.01; P = 0.0336) and greater than 4000 pg/mL (adjusted β: − 138.10, 95% [CI]: − 272.87 to − 10.33; P = 0.0181), weight loss was significant. Furthermore, the odds of full-term SGA were 1.40 times higher with E2 levels of 3001–4000 pg/mL (adjusted OR: 1.40, 95% [CI]: 1.090 to 3.18; P = 0.0256) and 2.55 times higher with E2 > 4000 pg/mL (adjusted OR: 2.55, 95% [CI]: 1.84 to 3.86; P = 0.0063) compared to the reference group. It can also be seen from the adjusted curves and the threshold effects that when the E2 level > 2950 pg/mL and > 3121 pg/mL, the incidence of SGA increased and the birthweight decreased, respectively. Conclusions Our data suggest that E2 levels > 2950 pg/mL is an independent predictor for greater odds of full-term SGA singletons born after fresh embryo transfer.

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Section: Discussionmentioning

confidence: 99%

E2 level > 2950 pg/ml on hCG trigger day is an independent predictor for birthweight loss of full-term singletons born after fresh embryo transfers in non-PCOS patients

Zhang

Wang

2022

Reprod Biol Endocrinol

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“…All patients were subjected to a long-term protocol of pituitary downregulation with gonadotrophinreleasing hormone (GnRH) agonist for controlled ovarian hyperstimulation (COH) as described previously [14].…”

Section: Superovulation Program and Embryo Culturementioning

confidence: 99%

Effects and safety of propofol intravenous anesthesia in transvaginal oocyte retrieval on outcomes of in vitro fertilization and embryo transplantation

Liu

Zhang²,

Zhong³

et al. 2022

Preprint

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Purpose Propofol is a common anesthetic agent used for oocyte retrieval procedures to reduce the pain and fear in outpatients. However, the potential effects and safety of propofol on in vitro fertilization and embryo transfer (IVF-ET) is not clear yet. Methods A total of 1187 patients undergoing IVF-ET were recruited in this retrospective study and divided into two groups depending on whether they received propofol (propofol group, n = 140) or not (control group, n = 1047) for anesthesia during oocyte retrieval. Results Baseline information did not differ between the two groups (p > 0.05). Compared with control group, the number of oocytes retrieved in propofol group was more (p = 0.012), while both the estradiol (E2) level on the trigger day and the pre-ovulatory follicle count were higher in propofol group ((p < 0.01). Furthermore, the preterm delivery rate was higher in the propofol group (p < 0.001). To further analyze the effect of propofol on the oocyte retrieval rate, patients were divided into three subgroups depending on the pre-ovulatory follicle count (≤ 10, 11–20, and > 20) to eliminate the influence of inconsistency in the estimation of the pre-ovulatory follicle count between the two groups. Data showed that oocyte retrieval with propofol was beneficial for getting more oocytes in the pre-ovulatory follicle count 11–20 subgroup (p < 0.001). Conclusion Oocyte retrieval with propofol had no negative effect on fertilization, embryo quality, and clinical outcomes, and could raise the oocyte retrieval rate in patients with an estimated pre-ovulatory follicle count 11–20. These findings provided evidence for further clinical applications of this technique.

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Which transfer day results in the highest live birth rate for PCOS patients undergoing in vitro fertilization?

Guo,

Dai,

Zheng

et al. 2023

BMC Pregnancy Childbirth

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Background Polycystic ovary syndrome (PCOS) has unusual levels of hormones. The hormone receptors in the endometrium have a hostile effect and make the microenvironment unfavorable for embryo implantation. The use of gonadotropin stimulation during in vitro fertilization (IVF) may have an impact on embryo implantation and live birth rate. According to recent data, the clinical results of day 4 embryo transfer (D4 transfer) were on par with those of day 5 embryo transfer (D5 transfer) in IVF-ET. There are few studies comparing the outcomes of transplants with various etiologies and days. The purpose of this study was to determine which transfer day had the best result for PCOS patients undergoing IVF. Methods This retrospective cohort study was conducted in the Xingtai Infertility Specialist Hospital between January 2017 and November 2021. A total of 1,664 fresh ART cycles met inclusion criteria, including 242 PCOS transfers and 1422 tubal factor infertility transfers. Conclusions PCOS individuals had the highest live birth rate on D4 transferred. It was not need to culture embryos to blastocysts to optimize embryo transfer for PCOS women. This could be a novel approach to transplantation for PCOS.

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Clinical and perinatal outcomes of fresh single-blastocyst-transfer cycles under an early follicular phase prolonged protocol according to day of trigger estradiol levels

Cited by 5 publications

References 37 publications

E2 level > 2950 pg/ml on hCG trigger day is an independent predictor for birthweight loss of full-term singletons born after fresh embryo transfers in non-PCOS patients

E2 level > 2950 pg/ml on hCG trigger day is an independent predictor for birthweight loss of full-term singletons born after fresh embryo transfers in non-PCOS patients

Effects and safety of propofol intravenous anesthesia in transvaginal oocyte retrieval on outcomes of in vitro fertilization and embryo transplantation

Which transfer day results in the highest live birth rate for PCOS patients undergoing in vitro fertilization?

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