Clinical and pharmacological aspects of accidental triamcinolone acetonide overdosage: a case study

Schweitzer, Dave H.; Lebrun, Pierre; Krishnaswami, Sriram; Derendorf, Hartmut

doi:10.1016/s0300-2977(99)00085-6

Cited by 15 publications

(4 citation statements)

References 11 publications

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“…One of these studies reported a complication after a ten-fold higher dose was accidentally given [16], and the other reported a case of a necrotizing fasciitis after a corticosteroid injection in the trochanteric bursa - which proved to be a lethal complication [17]. Necrotizing fasciitis after corticosteroid injection for trigger finger was presented as another severe complication [18].…”

Section: Resultsmentioning

confidence: 99%

Adverse effects of extra-articular corticosteroid injections: a systematic review

Brinks

Koes

Volkers

et al. 2010

BMC Musculoskelet Disord

193

122

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BackgroundTo estimate the occurrence and type of adverse effects after application of an extra-articular (soft tissue) corticosteroid injection.MethodsA systematic review of the literature was made based on a PubMed and Embase search covering the period 1956 to January 2010. Case reports were included, as were prospective and retrospective studies that reported adverse events of corticosteroid injection. All clinical trials which used extra-articular corticosteroid injections were examined. We divided the reported adverse events into major (defined as those needing intervention or not disappearing) and minor ones (transient, not requiring intervention).ResultsThe search yielded 87 relevant studies:44 case reports, 37 prospective studies and 6 retrospective studies. The major adverse events included osteomyelitis and protothecosis; one fatal necrotizing fasciitis; cellulitis and ecchymosis; tendon ruptures; atrophy of the plantar fat was described after injecting a neuroma; and local skin effects appeared as atrophy, hypopigmentation or as skin defect. The minor adverse events effects ranged from skin rash to flushing and disturbed menstrual pattern. Increased pain or steroid flare after injection was reported in 19 studies. After extra-articular injection, the incidence of major adverse events ranged from 0-5.8% and that of minor adverse events from 0-81%. It was not feasible to pool the risk for adverse effects due to heterogeneity of study populations and difference in interventions and variance in reporting.ConclusionIn this literature review it was difficult to accurately quantify the incidence of adverse effects after extra-articular corticosteroid injection. The reported adverse events were relatively mild, although one fatal reaction was reported.

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Section: Resultsmentioning

confidence: 99%

Adverse effects of extra-articular corticosteroid injections: a systematic review

Brinks

Koes

Volkers

et al. 2010

BMC Musculoskelet Disord

193

122

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“…Secondary hyperadrenocorticism, adrenal crisis, and anaphylaxis have been reported in humans following IA, topical, or local administration of glucocorticoids. [10][11][12][13][14] Decreased plasma concentrations of endogenous glucocorticoids following IA administration of methylprednisolone have been detected for up to 1 week in humans, 15 3 to 10 days in horses, 16,17 and 12 weeks in cows. 18 In horses, endogenous hydrocortisone does not reach pretreatment concentrations until 14 days after IM administration of TA.…”

Section: Phdmentioning

confidence: 99%

Pharmacokinetics of intra-articular, intravenous, and intramuscular administration of triamcinolone acetonide and its effect on endogenous plasma hydrocortisone and cortisone concentrations in horses

Soma¹,

Uboh²,

You³

et al. 2011

ajvr

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“…4 Several studies have shown that epidural or intra-articular administrations of glucocorticoid can impair glycemic control and decrease serum cortisol levels by suppressing HPAA, although this effect resolves after a few days or weeks. 11,12 In addition, splitting the dose between two or more joints has a greater and longer suppressive effect than when the total dose is delivered at one joint. 11,12 In addition, splitting the dose between two or more joints has a greater and longer suppressive effect than when the total dose is delivered at one joint.…”

mentioning

confidence: 99%

Changes in Blood Glucose and Cortisol Levels After Epidural or Shoulder Intra-articular Glucocorticoid Injections in Diabetic or Nondiabetic Patients

Moon

Choi²,

Lee³

et al. 2014

American Journal of Physical Medicine &Amp; Rehabilitation

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Clinical and pharmacological aspects of accidental triamcinolone acetonide overdosage: a case study

Cited by 15 publications

References 11 publications

Adverse effects of extra-articular corticosteroid injections: a systematic review

Adverse effects of extra-articular corticosteroid injections: a systematic review

Pharmacokinetics of intra-articular, intravenous, and intramuscular administration of triamcinolone acetonide and its effect on endogenous plasma hydrocortisone and cortisone concentrations in horses

Changes in Blood Glucose and Cortisol Levels After Epidural or Shoulder Intra-articular Glucocorticoid Injections in Diabetic or Nondiabetic Patients

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