Clinical and Pharmacological Studies on Alpha-1 Antagonists in Smooth Muscle of Human Urinary Bladder Base and Prostatic Urethra

Kunisawa, Y

doi:10.5980/jpnjurol1928.77.4_600

Jpn. j. urol

1986

DOI: 10.5980/jpnjurol1928.77.4_600

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Clinical and Pharmacological Studies on Alpha-1 Antagonists in Smooth Muscle of Human Urinary Bladder Base and Prostatic Urethra

Y Kunisawa

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1989

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The synthesis of the ¹⁴C and ²H‐isotopomers of (R)‐N‐[2‐(2′‐ethoxyphenoxy)‐ethyl]‐N‐2‐[3‐(4′‐methoxy‐3′‐sulfonamido)‐phenyl]‐propylamine hydrochloride, an α₁‐adrenoreceptor antagonist

Wheeler

Schmiegel

Hunden

1989

Labelled Comp Radiopharmac

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The synthesis of [14C]‐ and [2H]‐labeled LY253351 (YM12617–1), a potent α1‐receptor antagonist, which is potentially useful in the treatment of benign prostatic hypertrophy (BPH) is described. The [14C]‐isotopomer was synthesized from [14C]‐potassium cyanide in nine steps in 1.5% radiochemical yield. One of the key intermediates, [14C]‐4‐methoxyphenylacetone, was synthesized from [14C]‐4‐methoxyphenylacetyl chloride by a Pd(0)‐catalyzed reaction with tetramethylstannane. The [2H]‐labeled material was synthesized by a Pd/C catalyzed reductive amination with deuterium gas.

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The synthesis of the ¹⁴C and ²H‐isotopomers of (R)‐N‐[2‐(2′‐ethoxyphenoxy)‐ethyl]‐N‐2‐[3‐(4′‐methoxy‐3′‐sulfonamido)‐phenyl]‐propylamine hydrochloride, an α₁‐adrenoreceptor antagonist

Wheeler

Schmiegel

Hunden

1989

Labelled Comp Radiopharmac

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In vivo experiments for the evaluation of α1-adrenoceptor antagonistic effects of SGB-1534 on canine urethra

Imagawa¹,

Michitaka²,

Sakai³

1989

European Journal of Pharmacology

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Clinical and Pharmacological Studies on Alpha-1 Antagonists in Smooth Muscle of Human Urinary Bladder Base and Prostatic Urethra

Cited by 2 publications

References 0 publications

The synthesis of the ¹⁴C and ²H‐isotopomers of (R)‐N‐[2‐(2′‐ethoxyphenoxy)‐ethyl]‐N‐2‐[3‐(4′‐methoxy‐3′‐sulfonamido)‐phenyl]‐propylamine hydrochloride, an α₁‐adrenoreceptor antagonist

The synthesis of the ¹⁴C and ²H‐isotopomers of (R)‐N‐[2‐(2′‐ethoxyphenoxy)‐ethyl]‐N‐2‐[3‐(4′‐methoxy‐3′‐sulfonamido)‐phenyl]‐propylamine hydrochloride, an α₁‐adrenoreceptor antagonist

In vivo experiments for the evaluation of α1-adrenoceptor antagonistic effects of SGB-1534 on canine urethra

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Clinical and Pharmacological Studies on Alpha-1 Antagonists in Smooth Muscle of Human Urinary Bladder Base and Prostatic Urethra

Cited by 2 publications

References 0 publications

The synthesis of the 14C and 2H‐isotopomers of (R)‐N‐[2‐(2′‐ethoxyphenoxy)‐ethyl]‐N‐2‐[3‐(4′‐methoxy‐3′‐sulfonamido)‐phenyl]‐propylamine hydrochloride, an α1‐adrenoreceptor antagonist

The synthesis of the 14C and 2H‐isotopomers of (R)‐N‐[2‐(2′‐ethoxyphenoxy)‐ethyl]‐N‐2‐[3‐(4′‐methoxy‐3′‐sulfonamido)‐phenyl]‐propylamine hydrochloride, an α1‐adrenoreceptor antagonist

In vivo experiments for the evaluation of α1-adrenoceptor antagonistic effects of SGB-1534 on canine urethra

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Product

Resources

About

The synthesis of the ¹⁴C and ²H‐isotopomers of (R)‐N‐[2‐(2′‐ethoxyphenoxy)‐ethyl]‐N‐2‐[3‐(4′‐methoxy‐3′‐sulfonamido)‐phenyl]‐propylamine hydrochloride, an α₁‐adrenoreceptor antagonist

The synthesis of the ¹⁴C and ²H‐isotopomers of (R)‐N‐[2‐(2′‐ethoxyphenoxy)‐ethyl]‐N‐2‐[3‐(4′‐methoxy‐3′‐sulfonamido)‐phenyl]‐propylamine hydrochloride, an α₁‐adrenoreceptor antagonist