Clinical and phenomenological comparisons of delusional and non‐delusional major depression in the Chinese elderly

Lee, Tien-Wen; Tsai, Shih‐Jen; Yang, Cheng-Hung; Hwang, Jen‐Ping

doi:10.1002/gps.870

Cited by 16 publications

(41 citation statements)

References 23 publications

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“…On the other hand, two studies [15,22] found no differences regarding psychomotor disturbances. Parker et al [26,27,28,29] have found that delusional melancholics manifested a higher level of psychomotor disturbances (agitation or retardation) as compared to non-delusional melancholics.…”

Section: Clinical Characteristicsmentioning

confidence: 90%

“…Meyers and Greenberg [6] found that PDs had a statistically significant older age of depression onset and renewed the interest in this variable. On the other hand, Nelson et al [18], Baldwin [15] and Lee et al [22] have not found any difference between the two groups regarding age at onset of the disorder. Gournellis et al [16] reported that the PDs of the sample had, indeed, an older age at onset.…”

Section: Clinical Characteristicsmentioning

confidence: 95%

“…PMD in the elderly has been found to be a more severe form of depression with higher total depressive symptomatology, as measured by the Hamilton Rating Scale of Depression [14,15,16,22]. The elderly PDs manifested more feelings of guilt and less insight [14,15,16,22], anxiety [15], and hypochondriacal symptoms (14,16].…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…The elderly PDs manifested more feelings of guilt and less insight [14,15,16,22], anxiety [15], and hypochondriacal symptoms (14,16].…”

Section: Clinical Characteristicsmentioning

confidence: 99%

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Psychotic (Delusional) Major Depression in the Elderly: A Review

Gournellis¹,

Lykouras

2006

CPSR

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The prevalence in the community of psychotic (delusional) major depression (PMD) in the elderly was found to be 1%. In inpatient settings the frequency of the disorder varies between 24% and 53%. There is also evidence that its frequency increases in old age. In the elderly, PMD compared to non-PMD was found to be a more severe and melancholic form of depression with more psychomotor disturbances (agitation or retardation) and feelings of guilt, more anxiety and hypochondriacal complains and less insight. Delusional beliefs of paranoid and hypochondriacal content have been found to be prominent. Additionally, elderly psychotic depressives (PDs) are possibly at greater risk of suicide attempt. Also, elderly PDs have been observed to have more cognitive processing difficulties. As regards neurobiological findings, they have been found to have lower dopamine-beta-hydroxylase activity, smaller volume of prefrontal cortex, more brain stem and left-side frontotemporal atrophy, enlargement of the third ventricle and pontine reticular formation hypertensities. The prognosis for the disorder seems worse, with higher relapse rates and mortality although not all studies are in agreement. In the acute phase, the response to ECT is favourable (88%), however the response rates to combination of an antipsychotic and an antidepressant (25-50%) seem to be inferior to those observed in younger adults (70-80%). Close follow-up and continuation therapy with an antidepressant is needed to avoid relapses.

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Section: Clinical Characteristicsmentioning

confidence: 90%

Section: Clinical Characteristicsmentioning

confidence: 95%

Section: Clinical Characteristicsmentioning

confidence: 99%

“…The elderly PDs manifested more feelings of guilt and less insight [14,15,16,22], anxiety [15], and hypochondriacal symptoms (14,16].…”

Section: Clinical Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Psychotic (Delusional) Major Depression in the Elderly: A Review

Gournellis¹,

Lykouras

2006

CPSR

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“…26,27 One study found that delusional depressives' risk for suicide attempts was much higher than that of nondelusional depressives. 28 Another report described a case of a patient receiving IFNβ-1a therapy for MS who developed acute delirium, delusion, and depression that ceased with treatment discontinuation. 15 This patient had a history of depression prior to interferon therapy.…”

Section: Discussionmentioning

confidence: 99%

Depression Levels and Interferon Treatment in People with Multiple Sclerosis

Kim¹,

Foley²,

Picone³

et al. 2012

International Journal of MS Care

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Multiple sclerosis (MS) is the most common cause of neurologic disease in young and middle-aged adults, and 75% of patients are female. Nearly one in two patients with MS will experience clinically significant depression-approximately three times the prevalence rate in the general population. This study used a cross-sectional approach to examine the link between depression levels and use of interferon medications among individuals with MS. Data were collected from 694 patients of the Multiple Sclerosis Comprehensive Care Center at Holy Name Medical Center in Teaneck, New Jersey. Analysis of variance was used to compare depression scores between patients taking and not taking interferons. Regression analyses with depression scores as the dependent variable were also conducted. The Beck Depression Inventory (BDI) was reduced to a set of dimensions by principal components analysis. Two components were identified, reflecting somatic and cognitive symptoms. The results showed no significant relationship between depression levels and interferon treatment. Significant associations were observed between depression and both age and disability status, with younger, more disabled patients tending to be more depressed. Int J MS Care. 2012;14:10-16.

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