Clinical and Pneumo‐encephalographic Studies on Cerebral Atrophies of Middle Age

Frøshaug, H; Retterstøl, N

doi:10.1111/j.1600-0447.1956.tb04733.x

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be inferred from other studies which demonstrated that the degree of intellectual and personality disintegration ("dementia") correlated positively with the severity of atrophy, especially in the ventricular system (Asano, 1967;Haug, 1962;Huber, 1957;Lemke, 1936). On the other hand, the extremely high rates of abnormality found in some studies (50% to 95%) are unlikely to represent the schizophrenic population as a whole, since these percentages were based on studies of the most severely ill patients, the chronically hospitalized "demented" schizophrenics (Donovan, Galbraith, & Jackson, 1949;Froshaug & Retterstol, 1956;Jacobi & Winkler, 1927;Lemke, 1936;Moore, Nathan, Elliot, & Laubach, 1933). Those studies with a somewhat broader range of schizophrenic illnesses demonstrated that 25% to 70% of the chronic schizophrenic patients manifested cerebral atrophy (Ansink, Buis, & Tolsma, 1963;Asano, 1967;Haug, 1962;Huber, 1957;Young & Crampton, 1974).…”

Section: Pneumoencephalography (Peg)mentioning

confidence: 99%

Schizophrenia and brain dysfunction: An integration of recent neurodiagnostic findings.

Seidman¹

1983

Psychological Bulletin

321

122

View full text Add to dashboard Cite

This is a critical review and integration of recent evidence demonstrating the frequency, type, and clinical significance of brain dysfunction in schizophrenia. Neuroradiological, neurophysiological, and neuropsychological data suggest brain impairment in at least 20% to 35% of schizophrenic patients. The abnormalities are nonspecific and can result from a variety of causes. Preliminary evidence suggests that there are two or more syndromes that differ in severity and type of brain abnormality, rather than a unitary schizophrenic illness. A complex, variable picture of brain dysfunction, including ventricular enlargement and cerebral atrophy, disturbances of cerebral metabolism, neuropsychologic deficits, and neurologic "soft" signs, is found especially in chronically impaired schizophrenics with "negative" symptoms. Extent and locus of dysfunction in a corticosubcortical arousal-attention system involving areas of the frontal cortex, limbic system, and brain stem reticular formation are hypothesized to determine the relative prominence of "positive" and "negative" symptoms. Future research on neuroanatomy, etiology, and treatment must take into account the heterogeneity of the schizophrenias and might fruitfully utilize the positive-negative dimension.

show abstract