Clinical and radiographic correlations in breast cancer patients with osseous metastases

Abstract

Serial metastatic bone series on 12 patients with skeletal metastases from carcinoma of breast were studied. Changes in the clinical and radiographic parameters of the patients were correlated. Patients were all treated on a research protocol evaluating "medical adrenalectomy" with aminoglutethimide or surgical adrenalectomy. Seventeen clinical changes were noted in twelve patients. Sixteen of these observations demonstrated positive clinical correlations with concurrent skeletal radiographs. A lytic bone pattern correlated clinically with progressive tumor growth. A blastic bone pattern was present when objective clinical data indicated disease remission.

Nasopharyngeal carcinoma: pattern of skeletal metastases

“…Although it has been a common belief that osteoblastic metastases tend to have a slower growth rate compared with osteolytic metastases, it has not been well substantiated (Greenfield, 1986). In their study of bone metastases from breast cancer, Barry et al (1981) showed that a lytic pattern correlated with progressive tumour growth, whereas blastic pattern correlated with clinical remission. The present study adds to the literature by showing that mixed or sclerotic bony metastases of nasopharyngeal carcinoma presented later compared with lytic lesions and also that patients with mixed or sclerotic metastases had significantly better survival after the diagnosis of skeletal involvement.…”

Performance of 2-Deoxy-2-[F-18]fluoro-d-glucose Positron Emission Tomography and Integrated PET/CT in Restaged Breast Cancer Patients

“…The most common sources for Bfalse^negative PET studies in restaging of breast cancer include sclerotic bone metastases [1,24,25] and primary or metastatic lobular carcinoma [26]. Bone metastases occur in up to 70% of patients with breast cancer [27]. Importantly, about 20% of patients develop Bbone-only^metastatic disease with a prevalence of osteoblastic lesions of about 15Y20% [28].…”

Radiosurgery for Metastatic Spinal Tumors: Follow-Up MR Findings

“…However, in 2 lesions, as sclerotic changes progressed at the periphery, the total area of dark signal intensity changes increased and the final volume seemed to increase (Fig 3). This expanded appearance has been described on plain films 20,24 and should not be misunderstood as tumor progression.…”

“…Pollen and Shlaer 19 described osteoblastic response on plain radiographs after successful treatment, including chemotherapy of metastatic cancer of the prostate. Others [20][21][22] also reported that development of a sclerotic rim at the periphery of the tumors, followed by centrip- etal filling of the whole lytic area, is the best sign of a healing response in the radiographs of osteolytic metastatic lesions. These sclerotic rims and osteoblastic changes in the radiographs are thought to be concordant with the dark signal intensities on T2-weighted images (Fig 2).…”