Clinical and radiographic evaluation of platelet-rich fibrin as an adjunct to bone grafting demineralized freeze-dried bone allograft in intrabony defects

Atchuta, Abhinav; Gooty, Jagadish Reddy; Guntakandla, Vikram Reddy; Palakuru, Sunil Kumar; Satyanarayana, D.; Palaparthy, Rajababu

doi:10.4103/jisp.jisp_99_19

Cited by 24 publications

(15 citation statements)

References 34 publications

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“…This agrees with Crea et al, (2014) who achieved a statistically significant improvement in the radiographic defect depth with OFD alone after 12 months. It also agrees with Atchuta et al, (2020) who reached a 20.24% reduction in radiographic defect depth after OFD of intrabony defects. On the other hand, space maintenance by bone grafts were proved in the literature to be effective in the process of regeneration by acting as structural scaffolds.…”

Section: Discussionsupporting

confidence: 91%

Clinical and radiographic evaluation of open flap debridement with or without Nanocrystalline Hydroxyapatite bone graft in management of periodontal intrabony defects

Elbattawy

Ahmed

2021

Egyptian Dental Journal

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Background: Nanocrystalline hydroxyapatite (n-HA) bone graft could improve proliferation and differentiation of periodontal ligament fibroblasts. The osteoconductive and biomimetic properties incorporated into the early stage of human physiological bone turnover assumed that deposition of these molecules promoted early osteogenesis in and around Nano Bone.Methods: 20 periodontitis patients with intra-bony defects participated in this clinical trial and treated with either open flap debridement (OFD) alone as control group or OFD and n-HA bone graft as intervention group. Clinical outcomes included plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) and gingival recession (GR). Bone defect area (BDA) was measured by digital periapical radiographs and linear measurements were used to calculate the radiographic bone fill. Measurements at baseline and 6-months postoperatively were subjected to statistical analysis.Results: Both OFD and OFD with n-HA bone substitute resulted in statistically significant improvement in all clinical and radiographic parameters from baseline to 6 months. But no significant difference was observed between both groups. After 6 months, OFD showed 2.4(±0.5) mm PD reduction and 1.2(±0.8)mm CAL gain, while n-HA group showed 3.2(±1.1)mm PD reduction and 2.7(±1.3)mm CAL gain. The BDA was reduced by 1.7(±1)mm 2 with OFD and by 3.4(±2.2)mm 2 in n-HA group. Conclusion:Both OFD and OFD with n-HA showed significant reduction in clinical and radiographic outcomes after 6 months with no statistically significant difference between them.Clinical relevance: Both treatment modalities are successful procedures for treating intrabony defects

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Section: Discussionsupporting

confidence: 91%

Clinical and radiographic evaluation of open flap debridement with or without Nanocrystalline Hydroxyapatite bone graft in management of periodontal intrabony defects

Elbattawy

Ahmed

2021

Egyptian Dental Journal

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“…Their addition was associated with a reduction in probing pocket depth, increased rate of implant attachment, lower facial swelling, and more robust bone healing 225–228 . The addition of PRF also improved the efficacy of DFDBA in treating periodontitis 229 . PRF was used to replace DFDBA in repairing periodontal defects in human patients showing successful results after 6 months 214 .…”

Section: Classificationmentioning

confidence: 99%

“…[225][226][227][228] The addition of PRF also improved the efficacy of DFDBA in treating periodontitis. 229 PRF was used to replace DFDBA in repairing periodontal defects in human patients showing successful results after 6 months. 214 They have exhibited similar bone regeneration and clinical attachment levels as allografts 230 and autografts 231 in treating human intrabony periodontal defects.…”

Section: Platelet-rich Fibrinmentioning

confidence: 99%

A novel classification of bone graft materials

2022

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Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Therefore, this review aims to integrate and bring together the published data on bone substitutes within the last 5 years and produce a novel classification that would provide bone material researchers with a better understanding of what materials have so far been used and evaluated and the areas, where research is lacking and deserves more attention. The literature available in all major databases was obtained and filtered using an elimination criterion to extract all the articles related to studies that tested bone substitute materials in nonclinical and clinical trials over the last 5 years. The review article would provide bone material researchers with an insight into the materials that have been evaluated for bone tissue engineering applications and identify future perspectives for bone graft material research.

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“…Atchuta et al reported that a combination of PRF and DFDBA improved the clinical and radiographic parameters when used in regeneration of intrabony defects in chronic periodontitis patients [48].…”

Section: Randomized Controlled Clinical Trialmentioning

confidence: 99%