Clinical and radiographic evaluation of the efficacy of platelet-rich plasma combined with hydroxyapatite bone graft substitutes in the treatment of intra-bony defects in maxillofacial region

Durmuşlar, Mustafa Cenk; Alpaslan, Cansu; Alpaslan, Gökhan; Çakır, Melih

doi:10.3109/00016357.2014.926023

Cited by 19 publications

(9 citation statements)

References 25 publications

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“…Since PRP is an easy obtaining cost-effective source of growth factors, it has been used in combination with grafts and other natural and synthetic scaffolds such as hydroxyapatite, coral skeleton, chitosan, polymers and hydrogels (Roffi et al 2013;Oryan et al 2014;Salamanna et al 2015). Durmuslar et al (2014) assessed bovine hydroxyapatite, PRP and resorbable collagen membranes for the treatment of intra-bony defects and reported healing acceleration. In another study, Schneppendahl et al (2015) evaluated an autograft and PRP in a diaphyseal bone defect and obtained desired histomorphometric and radiographic results.…”

Section: Discussionmentioning

confidence: 99%

The role of fish scale derived scaffold and platelet rich plasma in healing of rabbit tibial defect: an experimental study

et al. 2018

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Fish scale is rich in collagen type I and hydroxyapatite, resembling bone structure. It is readily available, cost effective and can compensate for the limitations of grafting methods such as unavailability, zoonotic disease transmission, and high cost. The aim of this study was to evaluate in vivo the fish scale potential and the possible synergistic effect of platelet rich plasma (PRP) with this scaffold in bone regeneration. Fifteen male white New Zealand rabbits were randomly divided into six groups, each involving 5 limbs. Full thickness bicortical defects were created in the proximal tibia of both pelvic limbs of rabbits. The defect was left untreated in the negative control group. In experimental groups the defect was filled with PRP (group 1), cellular fish scale (group 2), combination of cellular fish scale and PRP (group 3), acellular fish scale (group 4), and a combination of acellular fish scale and PRP (group 5). Fresh fish scales were decellularized to increase biocompatibility and reduce immunity reactions. Decellularization was confirmed by DAPI (4',6-diamidino-2-phenylindole) staining. The microstructure and surface characteristics of fish scales were assessed by scanning electron microscopy (SEM). Histopathological evaluation of bone healing was performed on day 56. Although there was no significant difference in the bone union among experimental groups, the union was superior in all experimental groups compared to control. Spongiosa and cortex formation were superior in the acellular groups. Furthermore, PRP promoted bone marrow formation. We concluded that fish scale is a biocompatible scaffold with a high regenerative potential.

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Section: Discussionmentioning

confidence: 99%

The role of fish scale derived scaffold and platelet rich plasma in healing of rabbit tibial defect: an experimental study

et al. 2018

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“…The efficacy of platelets-rich plasma combined with bovine hydroxyapatite bone graft and resorbable membrane was investigated both clinically and radiographically for the treatment of intrabony pockets on the distal aspect of L2M following the surgical extraction of fully impacted L3M. The study concluded that the combined use of platelet-rich plasma with bovine hydroxyapatite bone graft materials for the treatment of intrabony defects might be an appropriate approach when the main goal is providing earlier bone regeneration [ 15 ]. Another combination that included platelet-rich plasma and a resorbable membrane of procaine origin (Bio-Gide; Geistlich Biomaterials, Wolhusen, Switzerland) was investigated in a randomized controlled trial in 2009.…”

Section: Discussionmentioning

confidence: 99%

A New Multi-Ingredient Recipe for the Treatment of Localized Advanced Periodontal Disease following the Surgical Removal of Impacted Wisdom Teeth

Khzam¹,

Fell²,

Fisher³

et al. 2016

Case Reports in Dentistry

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Periodontal disease is a chronic inflammation of the tooth supporting structures. It leads to bone and attachment loss which is irreversible. Extraction of horizontally impacted lower third molar (L3M) teeth may result in localized periodontal pockets at the distal aspect of the adjacent lower second molars (L2M). We present a case of a 21-year-old male who suffered from a swelling and pain around his lower right second molar following surgical removal of a mesioangular impacted lower right third molar. We showed that oral hygiene measures, surgical access, mixture of autogenous and synthetic bone graft, and guided tissue regeneration (GTR) were enough to control the problem.

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“…To prevent periodontal pocket formation and promote uneventful bony healing, grafting with biomaterials can be considered [16,17]. Autogenous bone is generally considered the gold standard for bone graft, and synthetic materials such as hydroxyapatite are considered an alternative for the reconstruction of the extraction socket [18]. Ridge preservation materials have been used as filling materials for the extraction socket.…”

Section: Introductionmentioning

confidence: 99%

Clinical Study for Silk Mat Application into Extraction Socket: A Split-Mouth, Randomized Clinical Trial

Kim

et al. 2019

Applied Sciences

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Silk mat originates from the cocoon of the silkworm and is prepared by a simple method. The material has been used for guided bone regeneration (GBR) in animal models. In this study, the silk mat used for a clinical application was compared with a commercially available membrane for GBR. A prospective split-mouth, randomized clinical trial was conducted with 25 patients who had bilaterally impacted lower third molars. High-density polytetrafluoroethylene (dPTFE) membrane or silk mat was applied in the extraction socket randomly. Probing depth (PD), clinical attachment level (CAL), and bone gain (BG) were measured at the time of extraction (T0) and then at three months (T1) and six months after extraction (T2). There was no missing case. GBR with silk mat was non-inferior to GBR with dPTFE for PD reduction at T1 and T2 (pnon-inferiority < 0.001). PD and CAL were significantly decreased at T1 and T2 when compared with those at T0 in both membrane groups (p < 0.001). BG at T2 was 3.61 ± 3.33 mm and 3.56 ± 3.30 mm in the silk mat group and dPTFE group, respectively. There was no significant complication from the use of silk mat for the patients. The results for patients undergoing GBR with silk mat for third-molar surgery were non-inferior to GBR with dPTFE for PD reduction.

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Clinical and radiographic evaluation of the efficacy of platelet-rich plasma combined with hydroxyapatite bone graft substitutes in the treatment of intra-bony defects in maxillofacial region

Abstract: Combined use of PRP and bovine-derived HA graft materials for the treatment of intra-bony defects might be an appropriate approach when the main goal is providing earlier bone regeneration.

Cited by 19 publications

References 25 publications

The role of fish scale derived scaffold and platelet rich plasma in healing of rabbit tibial defect: an experimental study

The role of fish scale derived scaffold and platelet rich plasma in healing of rabbit tibial defect: an experimental study

A New Multi-Ingredient Recipe for the Treatment of Localized Advanced Periodontal Disease following the Surgical Removal of Impacted Wisdom Teeth

Clinical Study for Silk Mat Application into Extraction Socket: A Split-Mouth, Randomized Clinical Trial

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