“…After stratification by MC subtype, nine studies were included that reported on leg pain in patients without Modic changes, 29,30,32,33,35,36,38,39,42 ten examined patients with MC-I, 29,30,32,33,35,36,38,39,41,42 and eight reported on leg pain in patients with MC-II. 29,30,32,33,36,39,41,42 Forest plots revealed a high degree of data heterogeneity (I 2 = 61%, P < .01). MC subtypes were not significantly associated with difference in VAS leg scores ( P = .38) (Supplemental Figure 3).…”