Clinical and Radiologic Features of Neuroendocrine Breast Carcinomas

Jeon, Chang Ho; Kim, Sun Mi; Jang, Mijung; Yun, Bo La; Ahn, Hye Shin; Kim, Sung Won; Kang, Eunyoung; Park, So Yeon

doi:10.7863/ultra.33.8.1511

Cited by 15 publications

(28 citation statements)

References 17 publications

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“…Imaging examination such as mammography, ultrasonography, or MRI could provide some helpful imaging findings, but there was still a degree of difficulty in the diagnosis of NEBC by imaging examination; a number of NEBC patients appeared to have signs of common breast carcinomas such as ill-defined margins, irregular shapes, calcification, and so on, and other patients’ breast carcinomas might show regular shapes and well-circumscribed margins just like benign lesions 15,16. As previously reported, the imaging characteristics of NEBC in our study were also variable on radiography (Tables S1 and S2), but the majority of NEBC tended to present poor features in mammography or ultrasonography.…”

Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine breast carcinomas: a retrospective analysis and review of literature

Yang

Cao

Chen

et al. 2017

OTT

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BackgroundPrimary neuroendocrine breast carcinomas (NEBCs) are a rare type of breast carcinomas that lack comprehensive recognition, including the clinicopathological features, therapeutic strategies, and prognostic significance. The aim of this retrospective analysis is to present and analyze our own data of primary NEBCs.Materials and methodsWe retrospectively reviewed the medical records from 2005 to 2015 in The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China to obtain a cohort of breast carcinoma patients who were confirmed to have primary NEBC by histopathology. The detailed clinical data along with histopathology, treatment, and follow-up aspects were gathered for analysis.ResultsThis retrospective analysis included 19 patients with a histopathological diagnosis of primary NEBC from 2005 to 2015. Their mean age was 59.2 years (ranging from 17 to 82 years). The majority of patients (15/19) focused on stages I and II. Of the 15 patients, 14 were positive for estrogen receptor, and 11 were positive for progesterone receptor. For neuroendocrine markers, the expression rates were 8/19, 14/18, 12/14, and 2/6 for chromogranin A, synaptophysin, neuron-specific enolase, and CD56, respectively. All operable patients except the one stage M1 underwent a surgery and 4/18 had axillary lymph node metastasis. Chemotherapy was performed in 12/19, and endocrine therapy in 8/10. With a median follow-up of 59.2 months, only 2 cases progressed after postoperative systemic therapy.ConclusionThe understanding of NEBC is limited due to its rarity. More evidence should be provided to enhance the understanding of NEBC, especially for diagnosis, treatment, and prognosis.

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Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine breast carcinomas: a retrospective analysis and review of literature

Yang

Cao

Chen

et al. 2017

OTT

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“…On the other hand, radiological imaging cannot offer much in differentiating the various lesions. The appearance of breast nodules on MRI and ultrasound is substantially similar to the case of metastatic and primary NENs, as well as the case of breast carcinoma [22,26,69]. Additional radionuclide imaging can be useful in differentiating NENs, as the majority of them express SSTR compared to ductal mammary carcinomas [25,28,70].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, morphological and functional imaging can play an important role in differential diagnosis. At mammographic evaluation, the breast NET appears as a more round circumscribed mass, while the breast carcinoma has more speculated edges and often has evidence of microcalcifications, which are usually absent in a NEN of the breast [67,69].…”

Section: Discussionmentioning

confidence: 99%

The rare entity of bilateral and unilateral neuroendocrine metastases to the breast: a case series and literature review

Zagami

Kandaraki

Renne

et al. 2020

ecancer

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Introduction Primary neuroendocrine neoplasms (NENs) in the breast are very rare. Until 2011, the prevalence was 0.1% of all breast lesions and 1% of all NENs, whereas metastatic breast NENs represent 1%–2% of all breast tumours. However, it seems that over the last 5 years the diagnostic frequency of breast NENs has increased, probably for more alert specialists and advanced diagnostic tools, leading to a prevalence of 2%–5% of diagnosed breast cancers, mostly in the elderly population. Breast metastases from extramammary malignancies are uncommon and bilateral ones are even more uncommon, with few reported in the literature. We describe four clinical settings of breast metastases from different NENs and the multidisciplinary approach for diagnosis and treatment. Methods Four patients were found to have NEN primaries metastasised to the breast. A literature review was conducted to identify similar cases and characterise breast metastases from neuroendocrinal tumors (NETs). Results Two patients presented with bilateral breast metastases (one with well-differentiated panNET and another with atypical lung carcinoid) and two had unilateral (one with moderately differentiated lung NET and one with atypical lung carcinoid). There are about 13 cases of NEN breast metastases reported in the English literature. The ileum is the most common primary site, followed by the appendix, duodenum, pancreas and lung. Conclusion Breast lesions from extramammary primary often pose a diagnostic challenge, since a breast nodule can be the first and often the only presentation of the disease. However, differentiating between primary and secondary NEN breast lesions is essential, owing to different clinical management and prognosis.

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“…Patients with neuroendocrine carcinoma have been described as presenting with palpable masses and nipple discharge. [ 18 ] Mammographic features include oval, round, or lobular mass without associated calcifications. [ 17 19 ] Masses are usually circumscribed with a minority of cases having spiculated margins [ Figure 4 ].…”

Section: Neuroendocrine Carcinomamentioning

confidence: 99%