Clinical and radiologic response in patients with bone metastases managed with combined radiotherapy and bisphosphonates

Vassiliou, Vassilios; Kardamakis, D.; Kalogeropoulou, Christina

doi:10.1002/jso.21145

Cited by 4 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data support and confirm a dominant effect of ZA as an inhibitor of osteoclastic activity, even in the long-term treatment. Previous reports have shown the effect of concomitant ZA and radiation treatment on density of bone metastases [30] . Radiation therapy alone has been previously shown to increase density of bone metastases by means of quantitative computed tomography [31] , [32] , [33] ; in our study, however, skeletal segments previously treated with radiation were not considered and excluded from analysis.…”

Section: Discussionmentioning

confidence: 95%

Differential effect of zoledronic acid on normal trabecular and cortical bone density in oncologic patients with bone metastases

Quattrocchi

Dell’Aia

Errante

et al. 2012

Journal of Bone Oncology

View full text Add to dashboard Cite

PurposeTo evaluate bone density changes at the level of normal bone and bone metastases after zoledronic acid (ZA) treatment in oncologic patients.Materials and methodsWe retrospectively evaluated 72 consecutive adult patients with histologically confirmed solid tumors with at least 1 newly diagnosed bone metastatic lesion. Bone metastases were diagnosed by bone scans and confirmed with computed tomography (CT). Patients received intravenous ZA, 4 mg, by 15-min infusion every 28 day through a peripheral or a central venous access and were monitored for at least 3 months and a maximum of 24 months. Bone density was determined at the level of bone metastases and at the level of normal trabecular and cortical bone using a ROI-based approach.ResultsA significant increase was demonstrated at the level of normal trabecular bone of the calvarium and the femoral neck. No significant increase of density was observed at the level of the normal cortical bone. Bone metastases showed a significant increase in CT density as compared to baseline up to 24 months after zoledronic acid.ConclusionWe have found that long term treatment with ZA increases trabecular bone density in oncologic patients whereas normal cortical bone changes are not detectable.

show abstract

Section: Discussionmentioning

confidence: 95%

Differential effect of zoledronic acid on normal trabecular and cortical bone density in oncologic patients with bone metastases

Quattrocchi

Dell’Aia

Errante

et al. 2012

Journal of Bone Oncology

View full text Add to dashboard Cite

show abstract

“…25 Addition bisphosphonates for pain relief and for recalcification is reasonable and should be discussed considering the prognosis. 26,27 Purely symptom-oriented irradiation of bone metastases to relieve pain in regions that have not received preoperative irradiation can be performed with 1 x 8 Gy. A meta-analysis has shown that one-time irradiation of uncomplicated bone metastases (no fracture, no neurological deficits) is as effective as fractionated irradiation relating to analgesia without intensifying toxicity.…”

Section: Bone Metastasesmentioning

confidence: 99%

“…However, in rapid-onset paralysis, compression of arterial vessels often occurs with subsequent spinal ischemia or even spinal cord infarction. 12,27,37 With respect to improved motor function, shortcourse radiotherapy is as effective as fractionated longer-course regimens. Longer regimens lead to fewer local relapses and should be applied to patients with a better prognosis.…”

Section: Spinal Cord Compressionmentioning

confidence: 99%