Clinical and radiological features of idiopathic interstitial pneumonias (IIPs): a pictorial review

Palmucci, Stefano; Roccasalva, Federica; Puglisi, Silvia; Torrisi, Sebastiano Emanuele; Vindigni, Virginia; Mauro, Letizia; Ettorre, G; Piccoli, Marina; Vancheri, Carlo

doi:10.1007/s13244-014-0335-3

Cited by 45 publications

(29 citation statements)

References 90 publications

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“…In patients with pneumonitis, the clinical features of pneumonitis were collected retrospectively from medical records. The severity of the pneumonitis was described using the criteria for interstitial lung diseases 12, 13, 14. The median follow‐up time for the case group was 239 days with a range from 12 to 610 days.…”

Section: Methodsmentioning

confidence: 99%

Risk factors for pneumonitis in patients treated with anti‐programmed death‐1 therapy: A case‐control study

Cui

Liu

Wang³

et al. 2018

Cancer Medicine

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Immune checkpoint blockade‐related pneumonitis is a rare but potentially life‐threatening adverse effect, but its risk factors are not completely understood. This case‐control study was conducted to identify pneumonitis risk factors in patients treated with anti‐PD1 monoclonal antibodies (mAbs), including all the patients who developed pneumonitis after anti‐PD‐1 mAbs treatment in the Cancer Center of the Chinese People's Liberation Army from September 2015 to September 2017. Two controls per case were matched according to a propensity‐score matching algorithm to account for confounding effects caused by individual baseline variables. Demographic and clinical information was obtained from medical records. In total, 55 cases and 110 controls were included in the study. No association was observed between smoking status or primary lung cancer and risk of pneumonitis. Significant risk factors for pneumonitis related to anti‐PD‐1 mAbs were prior thoracic radiotherapy, prior lung disease and combination therapy with odds ratios of 3.34 (1.51‐7.39), 2.86 (1.45‐5.64) and 2.73 (1.40‐5.31), respectively. The associations remained significant in the multivariable logistic regression model. The risk of pneumonitis induced by anti‐PD‐1 mAbs is associated with prior thoracic radiotherapy, prior lung disease, and combination therapy. Clinicians should monitor these features in patients receiving anti‐PD‐1 therapy to optimize clinical safety and efficacy.

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Section: Methodsmentioning

confidence: 99%

Risk factors for pneumonitis in patients treated with anti‐programmed death‐1 therapy: A case‐control study

Cui

Liu

Wang³

et al. 2018

Cancer Medicine

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“…Cyanosis may be seen. DIP may occur in association with connective tissue disorders such as scleroderma, lupus or rheumatoid arthritis, and their symptoms may accompany those of DIP (68).…”

Section: Clinical Featuresmentioning

confidence: 99%

Desquamative interstitial pneumonia: Risk factors, laboratory and bronchoalveolar lavage findings, radiological and histopathological examination, clinical features, treatment and prognosis (Review)

et al. 2018

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Desquamative interstitial pneumonia is a type of smoking-associated major idiopathic interstitial pneumonia, which is characterized by accumulation of alveolar macrophages in alveolar lumens and septa and develops secondary to mainly active or passive exposure to cigarette smoke. Desquamative interstitial pneumonia mostly occurs in male smokers in association with non-specific symptoms responsive to steroid therapy and has a better prognosis than usual interstitial pneumonia. To date, no large-scale clinical studies have been performed on desquamative interstitial pneumonia patients. Factors responsible for the scarcity of data on the clinical course of this condition include the retrospective nature of the available information as well as its rare occurrence. Despite this, a general consensus exists as to the nature of its symptoms, association with smoking, age and gender distribution, findings of respiratory function tests, steroid responsivity and mortality. The objective of the present review article was to report on desquamative interstitial pneumonia and to describe its etiology, risk factors and clinical features, as well as the laboratory, bronchoalveolar lavage, radiological and histopathological findings, and the treatment and prognosis of affected patients.

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“…35 NSIP is usually described as ground glass with subpleural sparing, reticulations, and/or traction bronchiectasis in the middle and lower lung zones. 36,37 The radiographic appearance of RA ILD is typically more consistent with the lower lobe honeycombing seen in idiopathic pulmonary fibrosis. 38 In comparison, pulmonary fibrosis in sarcoidosis tends to cause bilateral fibrocystic architectural distortion predominately the upper and mid lung zones 39 (►Fig.…”

Section: Clinical Features and Outcomesmentioning

confidence: 87%

Overlap Syndromes in Sarcoidosis: Clinical Features and Outcomes

James

2020

Semin Respir Crit Care Med

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Sarcoidosis is a multisystem inflammatory disease characterized by noncaseating granulomatous inflammation. While pulmonary sarcoidosis is most common, extrapulmonary involvement occurs in 50 to 74% of patients and can be the presenting abnormality in some patients. The diagnosis of sarcoidosis is based on a compatible clinical presentation in combination with granulomas on histology and exclusion of other causes. However, the absence of a diagnostic biomarker for sarcoidosis, in addition to the overlap of granulomatous inflammation and nonspecific clinical findings with other diseases, often results in a delayed diagnosis. Sarcoidosis overlap syndromes are typically described when sarcoidosis is diagnosed in the presence of another disease (concurrently or sequentially) with shared clinical and histologic features, or when sarcoidosis presents with clinical features typically observed in, but not diagnostic of, other diseases. Awareness of overlap syndromes is important for clinicians to avoid diagnostic errors and evaluate for concomitant diagnoses that may impact the management and outcome of sarcoidosis. This article is intended to provide an overview of these presentations and the most commonly associated diseases, with attention to their prevalence, clinical features, and reciprocal impacts on disease outcomes.

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Clinical and radiological features of idiopathic interstitial pneumonias (IIPs): a pictorial review

Cited by 45 publications

References 90 publications

Risk factors for pneumonitis in patients treated with anti‐programmed death‐1 therapy: A case‐control study

Risk factors for pneumonitis in patients treated with anti‐programmed death‐1 therapy: A case‐control study

Desquamative interstitial pneumonia: Risk factors, laboratory and bronchoalveolar lavage findings, radiological and histopathological examination, clinical features, treatment and prognosis (Review)

Overlap Syndromes in Sarcoidosis: Clinical Features and Outcomes

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