Clinical and radiological presentation of 95 orbital lymphoid tumors

Polito, Ennio; Galieni, Piero; Leccisotti, Antonio

doi:10.1007/bf00184859

Cited by 68 publications

(50 citation statements)

References 19 publications

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“…Some authors have used PCR analysis to detect IgH clonality of ocular adnexal lymphoid lesions (5,6,14,(17)(18)(19)(20), but it is not clear how often PCR reveals the clonality of ocular adnexal MALT lymphomas. We detected a monoclonal B-cell growth in 55% of the cases of MALT lymphoma by using PCR; in general, the PCR technique demonstrates the presence of a monoclonal B-cell population in 25 to 70% of the cases of MALT lymphoma (21).…”

Section: Discussionmentioning

confidence: 99%

“…This may reflect the malignant progression of the reactive phase, although the difference in age distribution was not statistically significant (P ϭ 0.16). Polito et al (5) reported that some cases of orbital non-Hodgkin's lymphoma were preceded by polyclonal lymphoid hyperplasia. We found that RLH involved lacrimal glands at a significantly high rate.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, some RLH cases were reported to be clonal according to PCR (5,17,18). It is possible that such cases contained lymphomatous elements since some of those cases of RLH showed Dutcher's bodies or immunohistological Ig light chain restriction.…”

Section: Discussionmentioning

confidence: 99%

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Clinical, Histopathological, and Immunogenetic Analysis of Ocular Adnexal Lymphoproliferative Disorders: Characterization of MALT Lymphoma and Reactive Lymphoid Hyperplasia

et al. 2001

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Malignant lymphomas and reactive lymphoid hyperplasia (RLH) in the ocular adnexa are sometimes difficult to differentiate morphologically and have often been categorized together as a lymphoproliferative disorder. Immunogenotypic characters of these diseases have not yet been well clarified. This study included 76 cases of ocular adnexal lymphoproliferative disorders. These consisted of 52 cases of malignant lymphoma (43 primary and 9 secondary), 22 of RLH, and 2 borderline cases. There were slightly more male than female subjects. Diagnoses were based on morphology and immunophenotypic characteristics. Clonalities were detected by means of polymerase chain reaction (PCR), and immunoglobulin heavy-chain variable region (VH) genes were sequenced in 10 cases of mucosa-associated lymphoid tissue (MALT) lymphoma. MALT lymphoma constituted 86% (37 cases) of the primary lymphomas. MALT lymphomas were more indolent, more rarely disseminated, and had a lower death rate than the other primary lymphomas. Two patients exhibited coexistence of MALT and diffuse large B-cell lymphoma. The average age of patients with RLH was 5.5 years younger than that of those with MALT lymphoma. One of the cases of RLH later progressed to malignant lymphoma. B-cell clonality was detected by PCR in 57%, 55%, and 0% of primary lymphomas, MALT lymphomas and RLHs, respectively. Sequencing of VH genes revealed that the VH3 family was the most commonly expressed germline VH family (70%) and that DP-63, DP-54 and DP-47 genes were frequently found in the MALT lymphomas examined. PCR analysis was useful for differentiation between MALT lymphoma and RLH. Sequence analysis of VH genes showed that an autoimmune mechanism may be involved in the lymphomagenesis of ocular adnexal MALT lymphoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical, Histopathological, and Immunogenetic Analysis of Ocular Adnexal Lymphoproliferative Disorders: Characterization of MALT Lymphoma and Reactive Lymphoid Hyperplasia

et al. 2001

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“…[1][2][3][4][5][6] Yeo et al studied 26 patients and found that lesions moulded or plastered themselves to pre-existing orbital structures, such as the globe, extraocular muscles, lacrimal gland, or bony orbital walls, without eroding bone or enlarging the orbit. Where lymphoid tumours abutted orbital fat they adopted a streaky profile, presumably due to irregular infiltration reflecting involvement of microfascial structural elements.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] Magnetic resonance imaging (MRI) studies have also been reported. [5][6][7] However, the imaging features of ocular adnexal lymphoproliferative disease have not been well described with regards to recent advances in imaging techniques. Further, there is no current protocol for imaging studies in patients with this disorder.…”

Section: Introductionmentioning

confidence: 99%

Imaging features of ocular adnexal lymphoproliferative disease

Sullivan

Valenzuela²

2006

Eye

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Purpose To evaluate the imaging characteristics of a cohort of patients with ocular adnexal lymphoproliferative disease (OALD). Methods A noncomparative retrospective review between 1992 and 1995 and prospective study from 1995 to 2005 of the clinical, imaging and treatment of 105 patients presenting to tertiary orbital referral centre presenting with OALD. Results One hundred and five patients (mean age 61 years, range 11-90 years) with equal gender distribution were included. Fifty-three were primary and 52 were secondary. Computed tomography (CT) usually showed a well-circumscribed lesion of greater than brain density, moulding to adjacent tissues with moderate enhancement. Aggressive histology was associated with bone destruction, while moulding was associated with indolent histology (Po0.005). MRI in OALD showed intermediate signal intensity on T1-and T2-weighted images and moderate enhancement with gadolinium. Gallium scanning sensitivity to detect ocular adnexal disease was 25 and 57% for systemic involvement. Positron emission tomography (PET) upstaged (71%) of patients with systemic lymphoproliferative involvement, having a higher sensitivity than CT in detecting distant disease (86 vs 72%). Conclusions CT and/or MRI are essential in the evaluation of OALD and can be used to establish that an orbital lesion may be lymphoprolifetaive in nature. Further, these imaging modalities may predict the behaviour of the lymphoma in certain cases. Gallium scanning provides no additional information to CT and does not influence patient treatment. PET represents an important addition to the assessment of OALD with real impact on patient management.

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MRI‐Based Radiomics Nomogram for Preoperative Differentiation Between Ocular Adnexal Lymphoma and Idiopathic Orbital Inflammation

Yang

Zhang

Xie

et al. 2022

Magnetic Resonance Imaging

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Background: Ocular adnexal lymphoma (OAL) and idiopathic orbital inflammation (IOI) are malignant and benign lesions for which radiotherapy and corticosteroids are indicated, but similar clinical manifestations make their differentiation difficult. Purpose: To develop and validate an MRI-based radiomics nomogram for individual diagnosis of OAL vs. IOI. Study Type: Retrospective. Population: A total of 103 patients (46.6% female) with mean age of 56.4 AE 16.3 years having OAL (n = 58) or IOI (n = 45) were divided into an independent training (n = 82) and a testing dataset (n = 21).Field Strength/Sequence: A 3-T, precontrast T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and postcontrast T1WI (T1 + C). Assessment: Radiomics features were extracted and selected from segmented tumors and peritumoral regions in MRI before-and-after filtering. These features, alone or combined with clinical characteristics, were used to construct a radiomics or joint signature to differentiate OAL from IOI, respectively. A joint nomogram was built to show the impact of the radiomics signature and clinical characteristics on individual risk of developing OAL. Statistical Tests: Area under the curve (AUC) and accuracy (ACC) were used for performance evaluation. Mann-Whitney U and Chi-square tests were used to analyze continuous and categorical variables. Decision curve analysis, kappa statistics, DeLong and Hosmer-Lemeshow tests were also conducted. P < 0.05 was considered statistically significant. Results: The joint signature achieved an AUC of 0.833 (95% confidence interval [CI]: 0.806-0.870), slightly better than the radiomics signature with an AUC of 0.806 (95% CI: 0.767-0.838) (P = 0.778). The joint and radiomics signatures were comparable to experienced radiologists referencing to clinical characteristics (ACC = 0.810 vs. 0.796-0.806, P > 0.05) or not (AUC = 0.806 vs. 0.753-0.791, P > 0.05), respectively. The joint nomogram gained more net benefits than the radiomics nomogram, despite both showing good calibration and discriminatory efficiency (P > 0.05). Data Conclusion: The developed radiomics-based analysis might help to improve the diagnostic performance and reveal the association between radiomics features and individual risk of developing OAL.

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Clinical and radiological presentation of 95 orbital lymphoid tumors

Abstract: An inflammatory presentation is not uncommon in orbital lymphoid tumors. Shape, molding and multiple masses can help radiological diagnosis, whereas MRI T2 intensity is unreliable. Accurate staging can disclose systemic disease in more than 50% of cases of non-Hodgkin lymphoma.

Cited by 68 publications

References 19 publications

Clinical, Histopathological, and Immunogenetic Analysis of Ocular Adnexal Lymphoproliferative Disorders: Characterization of MALT Lymphoma and Reactive Lymphoid Hyperplasia

Clinical, Histopathological, and Immunogenetic Analysis of Ocular Adnexal Lymphoproliferative Disorders: Characterization of MALT Lymphoma and Reactive Lymphoid Hyperplasia

Imaging features of ocular adnexal lymphoproliferative disease

MRI‐Based Radiomics Nomogram for Preoperative Differentiation Between Ocular Adnexal Lymphoma and Idiopathic Orbital Inflammation

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