Clinical and Serological Analysis of Patients with Positive Anticyclic Citrullinated Peptide Antibodies Referred Through a Rheumatology Central Triage System

Martin, Liam; Steber, Whitney A.; Lupton, Terri; Mähler, Michael; Fitch, Christie M.; McMillan, Jacob D.; Schmidt, Danielle R.; Fritzler, Marvin J.

doi:10.3899/jrheum.141054

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…The specificity of detection of anti-CarP antibodies is similar to IgM-RF and is slightly lower than anti-CCP2 antibodies. Even though anti-CCP2 antibodies and IgM-RF are both part of the 2010 classification criteria, individuals positive for these autoantibodies are also identified in the non-RA arthritis groups, as has also been reported before [ 15 – 17 ]. Therefore, it may not be surprising that anti-CarP antibodies, not being part of the 2010 classification criteria, can also be present in arthritic conditions other than RA.…”

Section: Discussionsupporting

confidence: 60%

“…In the current study, we observed that anti-CarP antibodies occur in almost all forms of early arthritis. Although at lower frequencies, anti-CCP antibodies were also detected in many other forms of arthritis (Table 2 ) [ 15 – 17 ]. Whether or not anti-CarP-positive patients with diagnoses other than RA have a different disease course than the anti-CarP-negative patients with the same diagnosis is a subject of future studies.…”

Section: Discussionmentioning

confidence: 99%

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The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis

Shi¹,

Steenbergen²,

Nies³

et al. 2015

Arthritis Res Ther

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IntroductionAnti-carbamylated protein (anti-CarP) antibodies have been described in rheumatoid arthritis (RA) and arthralgia patients at risk of developing RA. To what extent these autoantibodies are specific for RA is unknown. Therefore, we investigated the diagnostic performance of the presence of anti-CarP antibodies for RA in a setting of early arthritis.MethodsAnti-CarP antibodies were detected using carbamylated fetal calf serum as substrate. Anti-CCP2 antibodies were measured using enzyme-linked immunosorbent assay and immunoglobulin M (IgM) rheumatoid factor (RF) as part of routine care. Sera were derived from patients in the Leiden Early Arthritis Clinic cohort obtained at inclusion. Test characteristics were determined using the fulfillment of the 2010 RA criteria after 1 year as outcome.ResultsIn total 2086 early arthritis patients were studied regarding the presence of anti-CarP antibodies. We observed that the sensitivity and specificity of the presence of anti-CarP antibodies for RA were 44 % and 89 %, respectively. As a reference, sensitivity and specificity of the presence of anti-CCP2 antibodies were 54 % and 96 %, respectively, and of IgM-RF 59 % and 91 %. Patients harboring anti-CarP antibodies not classified as RA were mainly diagnosed with undifferentiated arthritis and less frequently reactive arthritis and psoriatic arthritis.ConclusionAnti-CarP antibodies are predominantly present in RA but can also be detected in other forms of arthritis.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis

Shi¹,

Steenbergen²,

Nies³

et al. 2015

Arthritis Res Ther

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show abstract

“…[22] In addition, the CReATe Rheum system has provided a novel opportunity to perform quality assurance analyses of various diagnostic services and the utilization of selected biomarkers to assist in the triage process [23,24]. Page 14 Our evaluation was limited by the pre-/post-study design.…”

Section: Page 13mentioning

confidence: 99%

Improving Appropriate Access to Care With Central Referral and Triage in Rheumatology

Hazlewood

Barr

Lopatina

et al. 2016

Arthritis Care & Research

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A scoping review of triage approaches for the referral of patients with suspected inflammatory arthritis, from primary to rheumatology care

Biln,

Bansback,

Shojania

et al. 2024

Rheumatol Int

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Clinical and Serological Analysis of Patients with Positive Anticyclic Citrullinated Peptide Antibodies Referred Through a Rheumatology Central Triage System

Abstract: About 58% of patients with a positive ACPA referred through a triage system for a rheumatologist opinion received a diagnosis of RA at their first visit. RF provides additional useful information to guide the diagnosis and urgency of referral.

Cited by 6 publications

References 20 publications

The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis

The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis

Improving Appropriate Access to Care With Central Referral and Triage in Rheumatology

A scoping review of triage approaches for the referral of patients with suspected inflammatory arthritis, from primary to rheumatology care

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