Clinical and Serological Aspects of the Aetiologic Differentiation of Auto-Immune Haemolytic Anaemias

Induction and Regulation of Autoimmune Hemolytic Anemia in Mice

“…Studies of AIHA in man and experimental mouse systems have provided evidence to support four major hypotheses on the cause ofthe autoimmunity (Dacie 1962, Isaacson 1967, Pirofsky 1968, Burnet 1969, 1972a, 1972b, Dacie & Woriledge 1969, Schubothe 1969). These are: 1) modification of erythrocyte antigens; 2) development of cross-reacting antibodies; i) emergence of for bidden elones of autoaggressive cells; and 4) abnormal T-cell function.…”

“…It has been hypothesized that erythrocyte antigens may be modified and thereby become autoimmunogenic (reviewed by Dacie 1962, Schubothe 1969. It is possible that viruses (Isaacson 1967), micro-organisms (Asherson 1968), or chemicals (Dacie & Worlledge 1969) provoke the change.…”