Clinical and serological one-year follow-up of patients after the bite of<i>Ixodes ricinus</i>ticks infected with<i>Borrelia burgdorferi</i>sensu lato

Briciu, Violeta; Flonta, Mirela; Țățulescu, D.; Meyer, Fabian; Sebah, Daniela; Cârstina, Dumitru; Mihalca, Andrei Daniel; Gherman, Călin Mircea; Hizo-Teufel, Cecilia; Huber, Ingrid; Fingerle, Volker; Lupşe, Mihaela

doi:10.1080/23744235.2016.1258488

Cited by 10 publications

(8 citation statements)

References 30 publications

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“…So far, studies conducted in Romania have evaluated the prevalence of Borrelia spp., N. mikurensis, Anaplasma spp., and Rickettsia spp. in I. ricinus [4][5][6][7][8]. The only study with a large dataset elaborated in Romania has evaluated the infection prevalence of B. burgdorferi s.l.…”

Section: Introductionmentioning

confidence: 99%

Multiple Tick-Borne Pathogens in Ixodes ricinus Ticks Collected from Humans in Romania

et al. 2020

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Ticks are medically important vectors of infectious diseases that are able to transmit pathogens to humans and animals. Tick-borne diseases represent a major health concern, posing an increasing risk to the public health during the last century and affecting millions of people. The aim of the current study was to provide epidemiological data regarding the presence of certain tick-borne pathogens in ticks feeding on humans in Romania. Overall, 522 Ixodes ricinus ticks collected from humans were screened for six pathogens: Borrelia spp., Neoehrlichia mikurensis, Babesia spp., Coxiella spp., Bartonella spp., and Francisella tularensis. Ticks attached to humans were collected between 2013–2015 in Cluj County, Romania. Conventional, nested and quantitative PCR were used to detect specific genetic sequences of each pathogen. For identifying the infectious agents, positive samples were sequenced. The infection prevalence was 21.07% from which 8.18% were mixed infections. The detected agents were Borrelia spp., N. mikurensis and Babesia spp. The present data reveal the endemic occurrence of potentially zoonotic pathogens in Romania. Revealing the current distribution of tick-borne pathogens in ticks collected from humans may provide new insights in understanding the complex ecology of tick-borne diseases and enlightens current knowledge about the infection prevalence at local, regional and national levels.

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Section: Introductionmentioning

confidence: 99%

Multiple Tick-Borne Pathogens in Ixodes ricinus Ticks Collected from Humans in Romania

et al. 2020

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“…Overall in Europe, including Poland, the Borrelia prevalence in ticks removed from humans range from 5-29% [33,34,35,37,38,40,41,42,43,44]. In our study, the Borrelia prevalence has differed signi cantly between I. ricinus ticks removed from humans (25%) and questing ticks (11%, [22]).…”

Section: Discussionmentioning

confidence: 51%

Long-Term Study of Borrelia and Babesia Species Distribution in Ixodes Ricinus and Dermacentor Recticulatus Ticks Removed From Humans in Poland, 2016-2019

Welc-Falęciak

Bednarska

Hamera

et al. 2021

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Monitoring changes in the prevalence of different Borrelia genospecies/ species in ticks might be an important indicator of risk assessment and of differences in pathogenicity in humans. Furthermore, the evaluation of pathogens in feeding ticks represents the risk of human exposure better than studies on questing ticks. The objective of our study was to assess the prevalence and distribution of Borrelia and Babesia species in ticks removed from humans, in a larger sample collected for several months during four years of studies. We confirmed high Borrelia prevalence, including B. miyamotoi, in ticks removed from humans as well as the shift in Borrelia genospecies/ species frequency of occurrence during the four-year study. Despite the fact that Babesia prevalence was relatively low, the majority of tested isolates are considered to be pathogenic for humans. The results of our study have also shown that Borrelia and Babesia coinfections in ticks are more common in Borrelia-infected ticks. Even if the overall risk of developing Lyme borreliosis after a tick bite in Europe is rather low, the knowledge of prevalence and distribution of Borrelia and Babesia species in ticks might be an important indicator of both tick-borne disease risk and pathogenicity assessment.

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“…Briciu et al reported a 9.1% seroprevalence of B. burgdorferi s.l. antibodies in humans after a tick bite, and in another study they evaluated the clinical and serological outcome of two groups of patients 1 year after tick bite [ 13 , 42 ]. In other studies, the prevalence of B. burgdorferi s.l.…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of antibodies against Borrelia burgdorferi sensu lato in healthy blood donors in Romania: an update

et al. 2021

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Background The Borrelia burgdorferi sensu lato (s.l.) genogroup is the causative agent responsible for Lyme borreliosis, a common tick-borne infectious disease in some temperate regions of the Northern Hemisphere. In humans, the clinical manifestations of Lyme borreliosis vary from dermatological infection to severe systemic manifestations. In Romania, data on the seroprevalence of Lyme borreliosis and associated risk factors are scarce and outdated, as the only seroprevalence study with a large dataset was published more than 20 years ago. Therefore, the aim of the present study was to evaluate the seroprevalence for Borrelia burgdorferi s.l. in healthy blood donors from six Romanian counties and identify the associated risk factors. Methods The study was conducted among 1200 healthy blood donors aged between 18 and 65 years during November 2019 and September 2020 from six counties in the northwestern and central parts of Romania. A two-tiered testing strategy was applied. Positive and equivocal immunoenzymatic test results for IgG and IgM antibodies were further confirmed by Western blot. Results Serum samples from 20% of the blood donors had positive or equivocal IgG and IgM ELISA index values. In total, 2.3% of the serum samples for IgG and 1.8% for IgM were positive by Western blot. The seroprevalence for both antibodies varied between 1.5% (Satu-Mare) and 6.5% (Bistrița-Năsăud) in the six counties investigated. The highest seroprevalence was observed in men (4.7%), in blood donors performing their professional activities outdoors (4.2%), and in those aged ≥ 56 years (8%). Conclusions These findings confirm the presence of specific IgG and IgM antibodies to B. burgdorferi s.l. among healthy blood donors from Romania. Furthermore, potential risk factors, such as gender, age, and behavior, associated with the presence of positive B. burgdorferi s.l. antibodies among healthy blood donors were identified. Graphical Abstract

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Clinical and serological one-year follow-up of patients after the bite ofIxodes ricinusticks infected withBorrelia burgdorferisensu lato

Abstract: No outcome differences were found between the group of patients bitten by B. burgdorferi positive ticks and the group of patients bitten by B. burgdorferi negative ticks.

Cited by 10 publications

References 30 publications

Multiple Tick-Borne Pathogens in Ixodes ricinus Ticks Collected from Humans in Romania

Multiple Tick-Borne Pathogens in Ixodes ricinus Ticks Collected from Humans in Romania

Long-Term Study of Borrelia and Babesia Species Distribution in Ixodes Ricinus and Dermacentor Recticulatus Ticks Removed From Humans in Poland, 2016-2019

Seroprevalence of antibodies against Borrelia burgdorferi sensu lato in healthy blood donors in Romania: an update

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