Clinical and Sociodemographic Characteristics Associated With Thick Melanomas

Grange, Florent; Barbe, Coralie; Aubin, F.; Lipsker, Dan; Granel‐Brocard, F.; Velten, Michel; Dalac, S.; Truchetet, F.; Michel, Catherine; Mitschler, A.; Arnoult, Guillaume; Buémi, Antoine; Dalle, S.; Bernard, Philippe; Woronoff, Anne‐Sophie

doi:10.1001/archdermatol.2012.2937

Cited by 28 publications

(31 citation statements)

References 42 publications

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“…The impact of marital status on melanoma stage of diagnosis and survival was investigated in six studies, and generally found that marriage appears to be protective and associated with earlier‐stage melanoma . All six studies provided grade B evidence.…”

Section: Resultsmentioning

confidence: 99%

Socioeconomic and lifestyle factors and melanoma: a systematic review

2015

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Evidence of social determinants of disease and awareness of the impact of these factors on outcomes continues to increase. Social determinants include both socioeconomic and lifestyle factors. This review examines the interface between socioeconomic status (SES) and lifestyle and their effects on melanoma incidence and mortality. Lifestyle factors including occupation, occupational exposures, body mass index, marital status, smoking, recreational sun exposure and tanning were explored as they have a known relationship with melanoma. A remarkable association of SES with melanoma incidence and prognosis has been acknowledged worldwide. Melanoma incidence is increased in populations of higher SES, especially among the highly educated, while lower SES populations present with later-stage disease at time of diagnosis and display greater mortality. The aforementioned lifestyle factors are also related to SES, and have been shown internationally to affect melanoma incidence and mortality. This comprehensive systematic review suggests that lifestyle factors including occupation, occupational exposure, obesity, recreational sun exposure and tanning may explain the relationship between SES and melanoma.

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Section: Resultsmentioning

confidence: 99%

Socioeconomic and lifestyle factors and melanoma: a systematic review

2015

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“…Failure to seek treatment may be the consequence of psychologic, socioeconomic (ie, poverty and insurance status 14,15 ), and potentially tumor-specific characteristics such as lack of pain 13,16–18 (see Table 1, Supplemental Digital Content, http://links.lww.com/AJDP/A42). GBCCs are rarely painful, even with deep tissue invasion, which may in part account for patient neglect.…”

Section: Introductionmentioning

confidence: 99%

Giant Basal Cell Carcinomas Express Neuroactive Mediators and Show a High Growth Rate: A Case–Control Study and Meta-Analysis of Etiopathogenic and Prognostic Factors

Abyaneh

Engel

Slominski

et al. 2017

The American Journal of Dermatopathology

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Background Giant basal cell carcinomas (GBCCs), (BCC ≥5 cm), are often painless, destructive tumors resulting from poorly understood patient neglect. Objectives To elucidate etiopathogenic factors distinguishing GBCC from basal cell carcinoma (BCC) and identify predictors for disease-specific death (DSD). Methods Case–control study examining clinicopathologic and neuroactive factors (β-endorphin, met-enkephalin, serotonin, adrenocorticotropic hormone, and neurofilament expression) in GBCC and BCC. Systematic literature review to determine DSD predictors. Results Thirteen GBCCs (11 patients) were compared with 26 BCCs (25 patients). GBCC significantly differed in size, disease duration, and outcomes; patients were significantly more likely to live alone, lack concern, and have alcoholism. GBCC significantly exhibited infiltrative/morpheic phenotypes, perineural invasion, ulceration, and faster growth. All neuromediators were similarly expressed. Adenoid phenotype was significantly more common in GBCC. Adenoid tumors expressed significantly more β-endorphin (60% vs. 18%, P = 0.01) and serotonin (30% vs. 4%, P = 0.02). In meta-analysis (n ≤ 311: median age 68 years, disease duration 90 months, tumor diameter 8 cm, 18.4% disease-specific mortality), independent DSD predictors included tumor diameter (cm) (hazard ratio (HR): 1.12, P = 0.003), bone invasion (HR: 4.19, P = 0.015), brain invasion (HR: 8.23, P = 0.001), and distant metastases (HR: 14.48, P = 0.000). Conclusions GBCC etiopathogenesis is multifactorial (ie, tumor biology, psychosocial factors). BCC production of paracrine neuro-mediators deserves further study.

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“…Des études se sont intéressées à rechercher des facteurs associés au développement de mélanomes épais (> 2 et 3 mm), ils ont retrouvé les types nodulaire et acrolentigineux, et les localisations céphalique et des membres inférieurs, en plus de facteurs sociodémographiques qui sont le sexe masculin, l’âge avancé, le bas niveau socioéconomique, les sujets qui vivent seuls et ceux qui n'ont pas été vus par un médecin durant les 3 dernières années avant le diagnostic de mélanome [16, 17]. …”

Section: Discussionunclassified

Mélanome cutané épais: facteurs de mortalité et de survenue de métastases

Tarwate¹,

Benchikhi²,

Adarmouch³

et al. 2014

Pan Afr Med J

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Au Maroc peu d’études ont été menées concernant les facteurs pronostiques du mélanome. L'objectif de cette étude était d'identifier les facteurs de survenue de métastases viscérales à distance à 1an et de mortalité à 2ans chez des patients atteints de mélanome cutané épais. Ont été colligés rétrospectivement tous les cas de mélanomes suivis au service de dermatologie et d'oncologie du CHU de Casablanca de 2006 à 2010. On été inclus les patients qui présentaient un mélanome à localisation cutanée et/ou muqueuse buccogénitale, confirmés histologiquement ayant un Breslow>2mm. Ont été exclus les patients présentant des métastases viscérales à distance au moment du diagnostic. Les données socio-démographiques, cliniques et thérapeutiques ont été recueillies au niveau des dossiers; celles relatives à l’évolution ont été complétées par contact téléphonique. L'analyse statistique était de type uni et bivarié. Soixante patients ont été inclus:41hommes et19femmes (sexe ratio de 2,15). La moyenne d’âge était de 60 ans (17-96). L'indice de Breslow était en moyenne de10mm+/-7et78%des patients(32) avaient un Breslow>4mm. Vingt trois patients (38,3%) avaient des adénopathies régionales. Quatorze patients ont présenté des métastases à distance après 1an (23,3%) et13patients étaient décédés après 2ans d’évolution (21,7%). Les facteurs associés à la survenue de métastases à distance étaient l'indice de Breslow. Des métastases à 1an ont été retrouvées chez 61,5%des patients avec un Breslow >10mm contre18,8% avec un Breslow

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Clinical and Sociodemographic Characteristics Associated With Thick Melanomas

Cited by 28 publications

References 42 publications

Socioeconomic and lifestyle factors and melanoma: a systematic review

Socioeconomic and lifestyle factors and melanoma: a systematic review

Giant Basal Cell Carcinomas Express Neuroactive Mediators and Show a High Growth Rate: A Case–Control Study and Meta-Analysis of Etiopathogenic and Prognostic Factors

Mélanome cutané épais: facteurs de mortalité et de survenue de métastases

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