Clinical and subclinical cardiovascular disease in female SLE patients: Interplay between body mass index and bone mineral density

Rodríguez‐Carrio, Javier; Martínez-Zapico, Aleida; Cabezas-Rodríguez, Iván; Fernández, Lorena Benavente; Pérez-Álvarez, Á.; López, Patricia; Cannata‐Andía, Jorge B.; Naves-Díaz, Manuel

doi:10.1016/j.numecd.2018.09.007

Cited by 10 publications

(4 citation statements)

References 45 publications

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“…Other non-Framingham traditional risk factors have also been associated with increased cardiovascular risk in SLE, including both high body mass index (BMI) >30, [ 35 ] and low BMI <20, [ 35 , 36 ] premature menopause, sedentary lifestyle, and increased waist-to-hip ratio. [ 37 ] Metabolic syndrome has also been associated with increased cardiovascular events and mortality.…”

Section: Causes Of Atherosclerosis In Slementioning

confidence: 99%

Cardiovascular disease in systemic lupus erythematosus

McMahon

Seto

Skaggs

2021

Rheumatology and Immunology Research

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There is a well-known increased risk for cardiovascular disease that contributes to morbidity and mortality in systemic lupus erythematosus (SLE). Major adverse cardiovascular events and subclinical atherosclerosis are both increased in this patient population. While traditional cardiac risk factors do contribute to the increased risk that is seen, lupus disease-related factors, medications, and genetic factors also impact the overall risk. SLE-specific inflammation, including oxidized lipids, cytokines, and altered immune cell subtypes all are likely to play a role in the pathogenesis of atherosclerotic plaques. Research is ongoing to identify biomarkers that can help clinicians to predict which SLE patients are at the greatest risk for cardiovascular disease (CVD). While SLE-specific treatment regimens for the prevention of cardiovascular events have not been identified, current strategies include minimization of traditional cardiac risk factors and lowering of overall lupus disease activity.

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Section: Causes Of Atherosclerosis In Slementioning

confidence: 99%

Cardiovascular disease in systemic lupus erythematosus

McMahon

Seto

Skaggs

2021

Rheumatology and Immunology Research

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“…1 As an example, low bone mineral density (BMD), which is measured by DXA machines, is associated with a significant risk of cardiovascular disease, morbidity and mortality. 25 DXA secondary data biometric measurements are also linked to diseases including obesity, diabetes mellitus and cancer. 26 Despite the fact that osteoporosis healthcare costs (including drug intervention) are increasing, the comprehensive utilization of healthcare big data in practice remains limited.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Conceptual design of the dual X-ray absorptiometry health informatics prediction system for osteoporosis care

Erjiang

Carey

Wang

et al. 2022

Health Informatics J

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Osteoporotic fractures are a major and growing public health problem, which is strongly associated with other illnesses and multi-morbidity. Big data analytics has the potential to improve care for osteoporotic fractures and other non-communicable diseases (NCDs), reduces healthcare costs and improves healthcare decision-making for patients with multi-disorders. However, robust and comprehensive utilization of healthcare big data in osteoporosis care practice remains unsatisfactory. In this paper, we present a conceptual design of an intelligent analytics system, namely, the dual X-ray absorptiometry (DXA) health informatics prediction (HIP) system, for healthcare big data research and development. Comprising data source, extraction, transformation, loading, modelling and application, the DXA HIP system was applied in an osteoporosis healthcare context for fracture risk prediction and the investigation of multi-morbidity risk. Data was sourced from four DXA machines located in three healthcare centres in Ireland. The DXA HIP system is novel within the Irish context as it enables the study of fracture-related issues in a larger and more representative Irish population than previous studies. We propose this system is applicable to investigate other NCDs which have the potential to improve the overall quality of patient care and substantially reduce the burden and cost of all NCDs.

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“…It was previously thought that the two were independent of each other, but epidemiological studies have proved the correlation between them [2,3]. In recent years, with the further study of the relationship between osteoporosis and CVD, it has been con rmed that they have similar risk factors in the elderly, especially in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular disease is a risk factor for osteoporosis: a case-control study in Chinese women

Chai¹,

Ge²,

Li³

et al. 2020

Preprint

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Background: Osteoporosis and cardiovascular disease (CVD) are age-related diseases. According to some studies, patients with CVD have a higher risk of bone loss. This retrospective study intended to reveal the correlation between osteoporosis and CVD in Chinese women. Although epidemiological evidence has provided evidence of the relationship between the two, it lacks clinical data in southeast China.Methods: The 2873 participants completed the baseline survey from January 2007 to October 2019, and 2496 were included in this retrospective study. We divided all subjects into the osteoporosis group and the non-osteoporosis group based on their bone mineral density. Dual-energy x-ray absorptiometry (DXA) was used to examine bone mineral density. The general information came from the questionnaire survey and medical records. Results: According to the criterion, the osteoporosis group had 799 subjects, with a mean age of 64.19 years. The non-osteoporosis group had 1697 subjects, with a mean age of 61.03 years. Subjects in the osteoporosis group had a significantly higher prevalence of hypertension and coronary heart disease. Besides, there was a higher probability of drinking tea and drinking milk in the osteoporosis group. In correlation analysis, the occurrence of osteoporosis correlated positively with hypertension and coronary heart disease. Logistic regression analysis showed that the odds of osteoporosis was high if participants had hypertension, coronary heart disease, or drank tea and drank milk. Conclusions: This study indicated that patients with osteoporosis had a higher prevalence of CVD in Chinese women, and CVD is one of the hazard factors for osteoporosis.

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Clinical and subclinical cardiovascular disease in female SLE patients: Interplay between body mass index and bone mineral density

Cited by 10 publications

References 45 publications

Cardiovascular disease in systemic lupus erythematosus

Cardiovascular disease in systemic lupus erythematosus

Conceptual design of the dual X-ray absorptiometry health informatics prediction system for osteoporosis care

Cardiovascular disease is a risk factor for osteoporosis: a case-control study in Chinese women

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