Clinical and survival analysis of 36 cases of primary fallopian tube carcinoma

Abstract

BackgroundPrimary fallopian tube carcinoma (PFTC) is rarely seen clinically. Herein, we investigate the clinical and pathological characteristics and appropriate therapies for PFTC.MethodsA total of 36 patients for whom PFTC was pathologically confirmed from January 2001 to July 2011 in Beijing Hospital of Gynecology and Obstetrics, an affiliate of Capital Medical University, were retrospectively analyzed.ResultsA total of 36 cases underwent surgical staging in our hospital: 47.2% were early stage cases , and 52.8% were advanced stage cases. Of the 36 cases, 24 cases were pure adenocarcinoma, 10 cases were mixed, and there was 1 case of undifferentiated carcinoma, 1 case of undifferentiated carcinoma combined with transitional cell carcinoma, 5 cases of moderately differentiated carcinoma, and 29 cases of moderately to poorly differentiated carcinoma. There were no cases of highly differentiated carcinoma. Among the cases examined, 38.9% (14/36) had omentum metastasis, and 19 cases had an elevated CA125 during a preoperative biochemical laboratory test. Approximately 35 cases received postoperative adjuvant chemotherapy. The 3-year and 5-year overall survival rates for the 36 cases were 80.7% and 65.4%, respectively. Single-factor analysis showed that the pathological conditions of residual tumor diameter >1 cm (P <0.001), omentum metastasis (P = 0.003), ovary metastasis (P = 0.004) and elevated preoperative CA125 (P = 0.044) were associated with prognosis, whereas pathological surgical staging (P = 0.069), retroperitoneal lymph node metastasis (P = 0.499), and pathological classification (P = 0.183) were not associated with prognosis. Multifactor analysis showed that a residual tumor diameter >1 cm (P = 0.019) and omentum metastasis (P = 0.015) were associated with prognosis, and were, therefore, the independent risk factors of prognosis.ConclusionsPFTC is a rare female genital tract malignancy. Most patients are in an advanced stage at diagnosis, which results in a poor prognosis. Complete surgical staging and maximal resection should be recommended.

Primary fallopian tube carcinoma: a single-institution retrospective study of 57 cases

“…In our current series, the mean age was 57.35±9.01 years, and univariate analysis is failed to find a significant correlation between the age and survival results. Meanwhile, 42 (73.7%) are postmenopausal patients with a mean postmenopausal period of 8.18±8.12 years (1-33years) in our cohort study, which is similar to previous reports [10,11]. All the evidence suggest postmenopausal women may be more prone to this malignancy.…”

Primary Fallopian Tube Carcinoma

“…Most studies failed to identify correlation between prognosis and omentectomy or omentum metastasis, 11,21,22 but one study reported omentum metastasis as an independent risk factor of prognosis. 35 In our study, the multivariate analysis revealed no significant difference between these factors in relation to survival, indicating their undefined role for PFTC.…”

Diagnostic and prognostic value of serum human epididymis protein 4 in patients with primary fallopian tube carcinoma

“…CA125 is a useful marker for PFTC progression during the follow‐up remission period after treatment, where it has been reported that CA125 levels increase prior to a clinical diagnosis of recurrence . Moreover, a recent study showed that CA125 had 57.6% (19/33) sensitivity in diagnosing PFTC, and was correlated to prognosis . However, because of the limitation of low specificity, CA125 is not very effective in the diagnosis of malignancies.…”

“…42 Moreover, a recent study showed that CA125 had 57.6% (19/33) sensitivity in diagnosing PFTC, and was correlated to prognosis. 43 However, because of the limitation of low specificity, CA125 is not very effective in the diagnosis of malignancies. HE4 is a novel, promising marker for diagnosis in women with suspected PFTC and when combined with CA125 has been proven to enhance sensitivity and specificity for the diagnosis of ovarian cancer; PFTC is similar to ovarian cancer and there is a lack of optimal management.…”