Clinical and Therapeutic Aspects of Linear Psoriasis: A Study of 30 Cases

Say, M.; Boralévi, F.; Lenormand, C.; Bursztejn, Anne‐Claire; Estève, É.; Phan, Alice; Bourrat, E.; Lacour, Jean‐Philippe; Richard, M.‐A.; Acher, Aurélie; Jullien, D.; Bénéton, N.; Descamps, V.; Bodemer, Christine; Lagaude, M.; Chiavérini, C.; Mahé, E.

doi:10.1007/s40257-018-0354-9

Cited by 13 publications

(4 citation statements)

References 27 publications

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“…Our research further updated the clinical characteristics of BLP. Compared with a study involving 30 patients with BLP conducted in France 6 years ago [ 3 ], we have agreements as well as new findings. The consistent aspects include earlier onset, unilateral distribution (no preference for left or right side), and triggering/aggravation factors (in about one-third of patients with BLP).…”

Section: Discussionsupporting

confidence: 76%

“…BLP can be the only manifestation of psoriasis (type I, or isolated type), or it can be superimposed in less severe disseminated classical lesions of psoriasis vulgaris, and unmasked when classical lesions fade away with antipsoriatic treatment (type II, or superimposed type) (Fig. 1 c) [ 2 , 3 ]. The term “superimposed type” was introduced in 2007 to highlight the distinction between polygenic and monogenic susceptibility backgrounds [ 4 ], which can help to elucidate the molecular basis of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

Chen,

Cheng,

Peng

et al. 2024

Dermatol Ther (Heidelb)

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Introduction Blaschko linear psoriasis (BLP) is characterized by the linear distribution of psoriatic skin lesions along the Blaschko lines. BLP can be divided into type I and type II, mainly on the basis of clinical manifestations. BLP can easily cause psychological burdens in patients and clinical confusion for physicians. Here, we summarize clinical cases to provide a better understanding of BLP. Methods The subjects included patients with BLP who visited our dermatology departments and those reported in the literature obtained from the PubMed and Wanfang databases. Quantitative data were presented as means ± SD (standard deviation), and qualitative data were represented by the frequency. Student’s t test was employed to compare means, whereas chi-square tests were used for analyzing qualitative data. Results A total of 74 patients with BLP (5 our patients, 69 from literature) were included, with 61 type I and 13 type II patients. We summarize BLP’s characteristics as follows: (1) More frequent in male individuals, especially in type II; (2) Earlier onset than classical psoriasis; (3) Mainly distributed unilaterally, and no preference for left or right site; (4) Asymptomatic or slight pruritus; (5) Mostly negative family history of psoriasis; (6) Possible involvement of the nails/scalp (mainly for type II); (7) Possible exogenous triggering or aggravation factors; (8) Possible concomitant classical plaque or guttate psoriasis lesions, especially in type II; (9) Conforming to histopathology features of classical psoriasis; (10) Relatively favorable response to antipsoriatic treatment, although poor for superimposed areas in type II. Conclusion This study analyzed the clinical characteristics and therapeutic aspects of BLP. Compared with published studies, we have new findings, such as gender bias. Besides traditional antipsoriatic treatment, a personalized selection of biologics may also be a promising choice. Dermatologists should recognize and understand the significance of this disease, and provide patients with appropriate psychological counseling and clinical treatments. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-024-01140-0.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

Chen,

Cheng,

Peng

et al. 2024

Dermatol Ther (Heidelb)

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“…In this study, a case of superimposed LP was reported when using methotrexate in two patients, infliximab in one patient and ethanol in one patient. 5 LP development has also been reported in a patient who has been using lithium 900 mg for 3 months due to bipolar disorder. 6 According to our research, there are no reported cases of LP related to sekukinumab in the literature.…”

mentioning

confidence: 75%

Unusual relapse in a psoriasis patient receiving secukinumab: Linear psoriasis

Kurtipek

Zekey

Akyürek

et al. 2020

Dermatologic Therapy

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“…Previous studies have reported that psoriasis often lead to increased risks of comorbidities, such as inflammatory arthritis, obesity, hypertension, and inflammatory bowel disease [2]. Unfortunately, the incidence of psoriasis is increasing year by year, with approximately 2-4% of population suffering from this disease in the world [3]. Current treatments of psoriasis mainly include topical therapy [4], phototherapy [5], immunotherapy [6], and systemic therapy [7].…”

Section: Introductionmentioning

confidence: 99%

Flexible liposomal gel dual-loaded with all-trans retinoic acid and betamethasone for enhanced therapeutic efficiency of psoriasis

Wang

Gao

et al. 2020

J Nanobiotechnol

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Background Psoriasis is a chronic immune-mediated inflammatory skin disease without effective treatment. The utilization of all trans-retinoic acid (TRA) and betamethasone (BT) for the treatment of psoriasis is still facing difficulties, due to their relatively poor stability, limited skin permeation, and systemic side effects. Flexible liposomes are excellent in deeper skin permeation and reducing the side effects of drugs, which is promising for effective treatment of skin disorders. This work aimed to establish dual-loaded flexible liposomal gel for enhanced therapeutic efficiency of psoriasis based on TRA and BT. Results Flexible liposomes co-loaded with TRA and BT were successfully prepared in our study. The characterization examination revealed that flexible liposomes featured nano-sized particles (around 70 nm), high drug encapsulation efficiency (> 98%) and sustained drug release behaviors. Flexible liposomes remarkably increased the drug skin permeation and retention as compared with free drugs. Results on HaCaT cells suggested that flexible liposomes were nontoxic, and its cellular uptake has a time-dependent manner. In vivo studies suggested the topical application of TRA and BT dual-loaded liposomal gel had the best ability to reduce the thickness of epidermal and the level of cytokines (TNF-α and IL-6), largely alleviating the symptoms of psoriasis. Conclusions Flexible liposomal gel dual-loaded with TRA and BT exerted a synergistic effect, which is a promising topical therapeutic for the treatment of psoriasis.

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Clinical and Therapeutic Aspects of Linear Psoriasis: A Study of 30 Cases

Abstract: We identified a wide range of LP, with two profiles: isolated LP and superimposed LP. Topical treatment usually evoked clinical response, with relative resistance to systemic therapy. Methotrexate and anti-tumor necrosis factor (TNF)-α therapies can possibly unmask LP.

Cited by 13 publications

References 27 publications

Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

Unusual relapse in a psoriasis patient receiving secukinumab: Linear psoriasis

Flexible liposomal gel dual-loaded with all-trans retinoic acid and betamethasone for enhanced therapeutic efficiency of psoriasis

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