Clinical and Therapeutic Evaluation of Patients With Moderate to Severe Psoriasis in Spain: The Secuence Study

Hernanz, J.M.; Sánchez‐Regaña, M.; Izu, R.; Mendiola, V.; García-Calvo, C.

doi:10.1016/j.adengl.2012.04.017

Cited by 10 publications

(14 citation statements)

References 21 publications

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“…Some studies have reported that patients with more severe disease had an earlier age of onset and a longer disease duration1923. Those results are in line with our findings.…”

Section: Discussionsupporting

confidence: 93%

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)

et al. 2017

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BackgroundPsoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date.ObjectiveTo understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea.MethodsThis multicenter, non-interventional, cross-sectional study recruited 1,278 adult patients with psoriasis across 25 centers in Korea in 2013. Various clinical data including PASI, BSA, DLQI, SF-36 and PASE were collected.ResultsA total of 1,260 patients completed the study (male:female=1.47:1). The mean age was 47.0 years with a distribution mostly in the 50s (24.9%). Early onset (<40 years) of psoriasis accounted for 53.9% of patients. The mean disease duration was 109.2 months; mean body mass index was 23.9 kg/m2; and 12.7% of patients had a family history of psoriasis. Plaque and guttate types of psoriasis accounted for 85.8% and 8.4%, respectively. Patients with PASI ≥10 accounted for 24.9%; patients with body surface area ≥10 were 45.9%. Patients with DLQI ≥6 accounted for 78.8%. Between PASI <10 and PASI ≥10 groups, significant difference was noted in age at diagnosis, disease duration, blood pressure, waist circumference of female, and treatment experiences with phototherapy, systemic agents, and biologics.ConclusionThis was the first nationwide epidemiologic study of patients with psoriasis in Korea and provides an overview of the epidemiologic characteristics and clinical profiles of this patient population.

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“…Some studies have reported that patients with more severe disease had an earlier age of onset and a longer disease duration1923. Those results are in line with our findings.…”

Section: Discussionsupporting

confidence: 93%

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)

et al. 2017

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“…The relation between age and HRQoL is not clear, or can even be considered a matter of controversy. Out of a total of eight studies, four indicated that young patients presented more deteriorated HRQoL, and established age as a factor related to a better HRQoL [13,21,25,26]. In contrast, three papers stated that older people experienced more problems with physical [17], emotional, and social functioning due to psoriasis [23,25].…”

Section: Hrqol and Patients' Characteristicsmentioning

confidence: 86%

“…Hernánz et al [26] Regression analysis: Higher PASI score was associated with an increased risk of poorer HRQoL: OR 1.067; CI 95 % = (1.037-1.098)…”

Section: Discussionmentioning

confidence: 96%

Health-related quality of life in patients with psoriasis: a systematic review of the European literature

et al. 2016

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“…Therefore, this study was designed to include only patients having exclusively skin lesions. Moreover, psoriatic patients with nail involvement and/or psoriatic arthritis are reported to have more severe psoriasis, as assessed by PASI, compared to those without [ 21 – 24 ]. Consequently, a relatively mild median PASI is likely in our sample.…”

Section: Methodsmentioning

confidence: 99%

Serum Levels of TNF-α, IL-12/23p40, and IL-17 in Plaque Psoriasis and Their Correlation with Disease Severity

Kyriakou

Patsatsi

Vyzantiadis

et al. 2014

Journal of Immunology Research

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A case-control study was performed to assess the serum levels of TNF-α, IL-12/23p40, and IL-17 in patients with plaque psoriasis, compare them with healthy controls, and correlate them with disease severity, as represented by Psoriasis Area Severity Index (PASI). 32 consecutively selected, untreated patients with active, chronic plaque psoriasis were recruited and compared to 32 age- and sex-matched healthy controls. Serum cytokine levels were determined by solid phase sandwich enzyme linked immunosorbent assay (R&D Systems Europe, Ltd.). The mean serum levels of TNF-α were significantly higher in psoriatic patients compared to those of controls (Mann-Whitney U test; P = 0.000). However, the median serum levels of neither IL-12/23p40 nor IL-17 differ significantly between the 2 groups (Mann-Whitney U test; P = 0.968 and P = 0.311, resp.). No significant correlations were found between PASI and any of the cytokine serum levels (Spearman's rank test; P > 0.05). Despite the well-evidenced therapeutic efficacy of biologic agents targeting TNF-α, IL-12/23p40, and IL-17, serum levels of TNF-α, IL-12/23p40, and IL-17 do not seem to correlate with the severity of psoriatic skin disease in untreated patients, as represented by PASI. Further investigation may add more data on the pathogenetic cascade of psoriasis.

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Clinical and Therapeutic Evaluation of Patients With Moderate to Severe Psoriasis in Spain: The Secuence Study

Cited by 10 publications

References 21 publications

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)

Health-related quality of life in patients with psoriasis: a systematic review of the European literature

Serum Levels of TNF-α, IL-12/23p40, and IL-17 in Plaque Psoriasis and Their Correlation with Disease Severity

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