Clinical and Translational Aspects of Normal and Abnormal Motility in the Esophagus, Small Intestine and Colon

Miller, Larry S.; Roland, Bani Chander; Whitson, Mathew; Passi, Monica; Cheung, Mary; Vegesna, Anil K.

doi:10.1016/b978-0-12-809954-4.00022-0

Cited by 3 publications

(4 citation statements)

References 247 publications

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“…[17][18][19][20] Colonic stimulation also elicits long-distance reflexes modulating the activity of other areas of the gut. 21 A recent study in a canine model showed that distension of the colon inhibits small bowel contractions via long-distance retrograde inhibitory reflexes. 22 Our data may have clinical relevance, since it suggests that colonic overload alters normal postprandial motility and hence, the interpretation of the small bowel manometry.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that experimental colonic distension in humans elicits propagated contractions via a local, peristaltic reflex directly mediated by the enteric nervous system 17–20 . Colonic stimulation also elicits long‐distance reflexes modulating the activity of other areas of the gut 21 . A recent study in a canine model showed that distension of the colon inhibits small bowel contractions via long‐distance retrograde inhibitory reflexes 22 …”

Section: Discussionmentioning

confidence: 99%

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Effect of colonic distension on small bowel motility measured by jejunal high‐resolution manometry

Alcalá-González

Malagelada

Livovsky

et al. 2022

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of colonic distension on small bowel motility measured by jejunal high‐resolution manometry

Alcalá-González

Malagelada

Livovsky

et al. 2022

Neurogastroenterology Motil

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“…Other ERAS protocol studies in GC which used only postoperative early oral feeding, and not CHO loading, resulted in reduced abdominal distension, nausea, and vomiting, and also hastened bowel recovery [29,30]. A study has demonstrated that prolonged fasting diminished the gastrointestinal peristalsis and caused irregular contraction waves instead of frequent eating peristalsis and regular contraction waves [31]. Therefore, postoperative early oral feeding not only accelerates intestinal function recovery, but also provides nutrients needed during recovery to maintain the intestinal mucosal barrier function and further accelerate organ recovery [8,32].…”

Section: Discussionmentioning

confidence: 99%

Impact of Enhanced Recovery after Surgery with Preoperative Whey Protein-Infused Carbohydrate Loading and Postoperative Early Oral Feeding among Surgical Gynecologic Cancer Patients: An Open-Labelled Randomized Controlled Trial

Ibrahim

Zaid

et al. 2020

Nutrients

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Enhanced Recovery after Surgery (ERAS) with sole carbohydrate (CHO) loading and postoperative early oral feeding (POEOF) shortened the length of postoperative (PO) hospital stays (LPOHS) without increasing complications. This study aimed to examine the impact of ERAS with preoperative whey protein-infused CHO loading and POEOF among surgical gynecologic cancer (GC) patients. There were 62 subjects in the intervention group (CHO-P), which received preoperative whey protein-infused CHO loading and POEOF; and 56 subjects formed the control group (CO), which was given usual care. The mean age was 49.5 ± 12.2 years (CHO-P) and 51.2 ± 11.9 years (CO). The trial found significant positive results which included shorter LPOHS (78.13 ± 33.05 vs. 99.49 ± 22.54 h); a lower readmission rate within one month PO (6% vs. 16%); lower weight loss (−0.3 ± 2.3 kg vs. −2.1 ± 2.3 kg); a lower C-reactive protein–albumin ratio (0.3 ± 1.2 vs. 1.1 ± 2.6); preserved muscle mass (0.4 ± 1.7 kg vs. −0.7 ± 2.6 kg); and better handgrip strength (0.6 ± 4.3 kg vs. −1.9 ± 4.7 kg) among CHO-P as compared with CO. However, there was no significant difference in mid-upper arm circumference and serum albumin level upon discharge. ERAS with preoperative whey protein-infused CHO loading and POEOF assured better PO outcomes.

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“…Finally, at a systems level, one can determine how each organ "talks" to the other organs within and outside of the GI tract, through hormones, nerves, and the passage of luminal contents. Common functional GI motility disorders include dysphagia, gastroesophageal reflux disease (GERD), functional dyspepsia, gastroparesis, chronic intestinal pseudo-obstruction (CIPO), postoperative ileus, irritable bowel syndrome, diarrhea, constipation, and fecal incontinence (Miller et al 2018).…”

Section: Physiology Of Gi Motility-nerves Muscles Interstitial Cells Of Cajal (Iccs) Sphincters and The Enteric Nervous Systemmentioning

confidence: 99%

Use of Bioelectronics in the Gastrointestinal Tract

Miller

Farajidavar

Vegesna

2018

Cold Spring Harb Perspect Med

Self Cite

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Gastrointestinal (GI) motility disorders are major contributing factors to functional GI diseases that account for >40% of patients seen in gastroenterology clinics and affect >20% of the general population. The autonomic and enteric nervous systems and the muscles within the luminal GI tract have key roles in motility. In health, this complex integrated system works seamlessly to transport liquid, solid, and gas through the GI tract. However, major and minor motility disorders occur when these systems fail. Common functional GI motility disorders include dysphagia, gastroesophageal reflux disease, functional dyspepsia, gastroparesis, chronic intestinal pseudo-obstruction, postoperative ileus, irritable bowel syndrome, functional diarrhea, functional constipation, and fecal incontinence. Although still in its infancy, bioelectronic therapy in the GI tract holds great promise through the targeted stimulation of nerves and muscles.

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Clinical and Translational Aspects of Normal and Abnormal Motility in the Esophagus, Small Intestine and Colon

Cited by 3 publications

References 247 publications

Effect of colonic distension on small bowel motility measured by jejunal high‐resolution manometry

Effect of colonic distension on small bowel motility measured by jejunal high‐resolution manometry

Impact of Enhanced Recovery after Surgery with Preoperative Whey Protein-Infused Carbohydrate Loading and Postoperative Early Oral Feeding among Surgical Gynecologic Cancer Patients: An Open-Labelled Randomized Controlled Trial

Use of Bioelectronics in the Gastrointestinal Tract

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