2009
DOI: 10.1016/j.brat.2008.10.015
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Clinical and treatment comparisons between adults with early- and late-onset obsessive-compulsive disorder

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Cited by 30 publications
(19 citation statements)
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“…The finding that BDD severity did not significantly differ between groups on most measures appears to conflict with data from OCD research which has found early age at onset to be associated with greater OCD symptom severity [22,24,26,28,31,35,36]. However, this finding is in accordance with one study on age at onset in social phobia [21] but conflicts with one other social phobia study [20].…”
Section: Discussioncontrasting
confidence: 67%
See 1 more Smart Citation
“…The finding that BDD severity did not significantly differ between groups on most measures appears to conflict with data from OCD research which has found early age at onset to be associated with greater OCD symptom severity [22,24,26,28,31,35,36]. However, this finding is in accordance with one study on age at onset in social phobia [21] but conflicts with one other social phobia study [20].…”
Section: Discussioncontrasting
confidence: 67%
“…Early age at onset was associated with greater symptom severity and increased comorbidity in one study on social phobia [20] but with greater comorbidity but not symptom severity in another study [21]. In OCD, early age at onset is usually associated with greater severity of symptoms [22,24,26,28,31,35,36] and greater comorbidity on both Axis I and Axis II [25,27,29,30,33]. However, Millet et al [24], Grant et al [22], and Tükel et al [31] found comorbidity rates to be similar across groups with different ages of onset.…”
Section: Introductionmentioning
confidence: 99%
“…Another limitation of this study is that the most of our OCD patients had late age of onset. Although there have been reports regarding clinical and neurobiological differences between early vs. late onset OCD patient groups [Lomax et al, 2009;Pauls et al, 1995], our study could not measure this early vs. late onset difference. Interestingly, a recent PET study reported more pronounced dysfunctions of the serotonin system in the ventral network, such as limbic, paralimbic, nuclesus accumbens, and striatal regions, in late onset OCD compared with early onset OCD and normal controls (Hesse et al, to appear).…”
Section: Limitationsmentioning
confidence: 84%
“…OCD severity was assessed with the YBOCS (Goodman et al 1986a, b). This threshold was indicated by most of the studies showing differences in clinical and therapeutic features as well as different familial loading (Fontenelle et al 2003 ; Lomax et al 2009 ;Nestadt et al 2000 ;Rosario-Campos et al 2001 ;Tü kel et al 2005). We defined 'age at onset ' as the age in which patients remembered the beginning of clinically significant distress or impairment associated with obsessions and/or compulsions.…”
Section: Participantsmentioning
confidence: 96%
“…used radiotracer and analytical approach) might account for study differences. Individuals who report an early onset of OCD (EO-OCD) have higher severity and worse response to SSRIs or cognitive-behavioural therapy (Lomax et al 2009 ;Rosario-Campos et al 2001). Previous research also indicated that there are clinical, demographic and neurobiological heterogeneities in OCD (Lochner & Stein, 2003).…”
Section: Introductionmentioning
confidence: 99%